Compounds > 1-aminonaphthalene-8-sulfonate
Page last updated: 2024-12-05

1-aminonaphthalene-8-sulfonate

Description

1-aminonaphthalene-8-sulfonate, also known as **1,8-ANS**, is a fluorescent probe used in research for various purposes, particularly in studying:

**1. Protein Structure and Dynamics:**

* **Binding to Hydrophobic Pockets:** 1,8-ANS is a hydrophobic molecule that readily binds to hydrophobic pockets within proteins. This binding can cause a significant increase in its fluorescence, making it useful for detecting and characterizing these pockets.
* **Conformational Changes:** Changes in protein conformation can affect the binding of 1,8-ANS, leading to alterations in its fluorescence properties. This makes it a valuable tool for studying protein dynamics and conformational changes upon ligand binding or environmental changes.
* **Membrane Interactions:** 1,8-ANS can also interact with lipid membranes, providing insights into membrane structure and dynamics.

**2. Enzyme Activity and Inhibition:**

* **Active Site Monitoring:** 1,8-ANS can be used to monitor changes in enzyme active sites during catalysis or upon inhibitor binding.
* **Inhibitor Screening:** The fluorescence changes upon binding of 1,8-ANS can be used to screen for potential inhibitors of enzyme activity.

**3. Other Applications:**

* **Cellular Imaging:** 1,8-ANS can be used for staining and visualizing various cellular structures and compartments.
* **Biophysical Studies:** 1,8-ANS is used in biophysical studies to investigate protein-protein interactions, protein folding, and other processes.

**Importance for Research:**

The key importance of 1,8-ANS in research lies in its ability to:

* **Report on the Hydrophobic Environment:** Its fluorescence is sensitive to the hydrophobicity of its environment, making it a valuable probe for studying hydrophobic interactions.
* **Signal Conformational Changes:** Its fluorescence changes in response to protein conformational changes, enabling the study of protein dynamics and ligand binding.
* **Serve as a Versatile Tool:** Its use is not limited to protein studies, extending to membrane interactions, cellular imaging, and biophysical studies.

**In summary**, 1-aminonaphthalene-8-sulfonate (1,8-ANS) is a widely used fluorescent probe that provides valuable insights into various aspects of protein structure, dynamics, and function. Its ability to sense hydrophobic environments and report conformational changes makes it a powerful tool for researchers across different fields.

1-naphthylamine-8-sulfonic acid: structure in Merck Index, 9th ed, #6232 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6722
SCHEMBL ID179823
MeSH IDM0099579

Synonyms (49)

Synonym
BIDD:GT0781
1-naphthylamine-8-sulfonic
.alpha.-naphthylamine-8-sulfonic acid
nsc-7798
peri acid
1-aminonaphthalene-8-sulfonate
1-aminonaphthalene-8-sulfonic acid
1-naphthalenesulfonic acid, 8-amino-
8-amino-1-naphthalenesulfonic acid
1-naphthylamine-8-sulfonic acid
nsc7798
1-amino-8-naphthalene sulfonate
82-75-7
naphthylaminemonosulfonic acid s
einecs 201-437-1
alpha-naphthylamine-8-sulfonic acid
schollkopf's acid (van)
8-aminonaphthalene-1-sulphonic acid
nsc 7798
AC-11031
1-amino-8-naphthalenesulfonic acid
A0350
8-aminonaphthalene-1-sulfonic acid
A840429
AKOS008969346
ccris 8906
0d93y3mxv4 ,
unii-0d93y3mxv4
FT-0621493
AE-641/00781027
1-amino-8-naphthylsulfonic acid
1-naphthylamine-8-sulfonic acid [mi]
AB01331397-02
SCHEMBL179823
8-amino-1-naphthalene sulfonic acid
DTXSID2058881
W-104161
STL428863
BBL034692
FD10527
mfcd00035730
F0348-4039
sr-01000198133
SR-01000198133-1
Z57188273
perisaure
NCGC00339200-01
Q27236642
EN300-18397
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (9.09)18.7374
1990's6 (54.55)18.2507
2000's3 (27.27)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.49

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.49 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.97 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.49)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.		2.3920sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
palmitic acid
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.		1.9810long-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor;
plant metabolite
pyrogallol
benzenetriol : A triol in which three hydroxy groups are substituted onto a benzene ring.		2.1710benzenetriol;
phenolic donor		plant metabolite
erythrosine
Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.		1.9710
guanidine
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.. guanidine : An aminocarboxamidine, the parent compound of the guanidines.		2.0310carboxamidine;
guanidines;
one-carbon compound
stearic acid
octadecanoic acid : A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and plastics.		1.9810long-chain fatty acid;
saturated fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
human metabolite;
plant metabolite
aspartic acid
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.		2.0110aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
lysine
Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.		2.0110aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
1,2-dipalmitoylphosphatidylcholine
1,2-Dipalmitoylphosphatidylcholine: Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.		1.9710
dimethyl sulfone
[no description available]		2.3920sulfone
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		1.9610erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
glutamic acid
Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.		2.0110glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
octyl glucoside
octyl-beta-D-glucoside: RN given refers to (beta)-isomer. octyl beta-D-glucopyranoside : An beta-D-glucoside in which the anomeric hydrogen of beta-D-glucopyranose is substituted by an octyl group.		1.9710beta-D-glucosideplant metabolite
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		1.9710D-glucopyranoseepitope;
mouse metabolite
6-carboxyfluorescein
6-carboxyfluorescein: originally sold as 6-carboxyfluorescein, but commercial product is a mixture of two isomers; correct name is 5(6)-carboxyfluorescein		1.9710monocarboxylic acid
glycosides
[no description available]		1.9710
bilirubin
[no description available]		1.9810biladienes;
dicarboxylic acid		antioxidant;
human metabolite;
mouse metabolite
diphenylhexatriene
Diphenylhexatriene: A fluorescent compound that emits light only in specific configurations in certain lipid media. It is used as a tool in the study of membrane lipids.		2.3720alkatrienefluorochrome
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		1.97101,2-diacyl-sn-glycero-3-phosphocholine
flavin mononucleotide
Flavin Mononucleotide: A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
chemdatabank.com