Page last updated: 2024-12-05

1-aminonaphthalene-8-sulfonate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-aminonaphthalene-8-sulfonate, also known as **1,8-ANS**, is a fluorescent probe used in research for various purposes, particularly in studying:

**1. Protein Structure and Dynamics:**

* **Binding to Hydrophobic Pockets:** 1,8-ANS is a hydrophobic molecule that readily binds to hydrophobic pockets within proteins. This binding can cause a significant increase in its fluorescence, making it useful for detecting and characterizing these pockets.
* **Conformational Changes:** Changes in protein conformation can affect the binding of 1,8-ANS, leading to alterations in its fluorescence properties. This makes it a valuable tool for studying protein dynamics and conformational changes upon ligand binding or environmental changes.
* **Membrane Interactions:** 1,8-ANS can also interact with lipid membranes, providing insights into membrane structure and dynamics.

**2. Enzyme Activity and Inhibition:**

* **Active Site Monitoring:** 1,8-ANS can be used to monitor changes in enzyme active sites during catalysis or upon inhibitor binding.
* **Inhibitor Screening:** The fluorescence changes upon binding of 1,8-ANS can be used to screen for potential inhibitors of enzyme activity.

**3. Other Applications:**

* **Cellular Imaging:** 1,8-ANS can be used for staining and visualizing various cellular structures and compartments.
* **Biophysical Studies:** 1,8-ANS is used in biophysical studies to investigate protein-protein interactions, protein folding, and other processes.

**Importance for Research:**

The key importance of 1,8-ANS in research lies in its ability to:

* **Report on the Hydrophobic Environment:** Its fluorescence is sensitive to the hydrophobicity of its environment, making it a valuable probe for studying hydrophobic interactions.
* **Signal Conformational Changes:** Its fluorescence changes in response to protein conformational changes, enabling the study of protein dynamics and ligand binding.
* **Serve as a Versatile Tool:** Its use is not limited to protein studies, extending to membrane interactions, cellular imaging, and biophysical studies.

**In summary**, 1-aminonaphthalene-8-sulfonate (1,8-ANS) is a widely used fluorescent probe that provides valuable insights into various aspects of protein structure, dynamics, and function. Its ability to sense hydrophobic environments and report conformational changes makes it a powerful tool for researchers across different fields.

1-naphthylamine-8-sulfonic acid: structure in Merck Index, 9th ed, #6232 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6722
SCHEMBL ID179823
MeSH IDM0099579

Synonyms (49)

Synonym
BIDD:GT0781
1-naphthylamine-8-sulfonic
.alpha.-naphthylamine-8-sulfonic acid
nsc-7798
peri acid
1-aminonaphthalene-8-sulfonate
1-aminonaphthalene-8-sulfonic acid
1-naphthalenesulfonic acid, 8-amino-
8-amino-1-naphthalenesulfonic acid
1-naphthylamine-8-sulfonic acid
nsc7798
1-amino-8-naphthalene sulfonate
82-75-7
naphthylaminemonosulfonic acid s
einecs 201-437-1
alpha-naphthylamine-8-sulfonic acid
schollkopf's acid (van)
8-aminonaphthalene-1-sulphonic acid
nsc 7798
AC-11031
1-amino-8-naphthalenesulfonic acid
A0350
8-aminonaphthalene-1-sulfonic acid
A840429
AKOS008969346
ccris 8906
0d93y3mxv4 ,
unii-0d93y3mxv4
FT-0621493
AE-641/00781027
1-amino-8-naphthylsulfonic acid
1-naphthylamine-8-sulfonic acid [mi]
AB01331397-02
SCHEMBL179823
8-amino-1-naphthalene sulfonic acid
DTXSID2058881
W-104161
STL428863
BBL034692
FD10527
mfcd00035730
F0348-4039
sr-01000198133
SR-01000198133-1
Z57188273
perisaure
NCGC00339200-01
Q27236642
EN300-18397
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (9.09)18.7374
1990's6 (54.55)18.2507
2000's3 (27.27)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.49

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.49 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.97 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.49)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]