Compounds > 1-amino-9,10-dihydro-9,10-dioxo-4-(phenylamino)-2-anthracenesulfonic acid
Page last updated: 2024-12-06

1-amino-9,10-dihydro-9,10-dioxo-4-(phenylamino)-2-anthracenesulfonic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-Amino-9,10-dihydro-9,10-dioxo-4-(phenylamino)-2-anthracenesulfonic acid, also known as **Acid Red 138**, is an **azo dye** with a complex chemical structure.

Here's why it's important in research:

* **Dyeing and Colorant Studies:** Acid Red 138 is a vibrant red dye widely used in various textile and printing applications. Researchers in the fields of dye chemistry, color science, and textile technology study its properties like lightfastness, washfastness, and color stability.
* **Analytical Chemistry:** This dye's properties make it useful in analytical chemistry for various assays and spectrophotometric techniques. Its ability to bind to specific molecules or materials can be harnessed for quantitative analysis.
* **Material Science:** Acid Red 138 has potential applications in materials science due to its color properties and ability to interact with different surfaces. Research in this field may explore its use in coatings, inks, and pigments.
* **Biological Staining:** Some research investigates the potential of Acid Red 138 as a staining agent in biological studies. Its ability to bind to specific structures or molecules could be useful in microscopy or other techniques.

**Important Notes:**

* It's crucial to be aware that dyes like Acid Red 138 can be toxic or harmful in certain applications. Always follow proper safety guidelines and protocols when working with these substances.
* This dye is only one example of a complex molecule studied in research. Thousands of other dyes and colorants exist with unique properties and applications.

Further research on Acid Red 138 could lead to:

* Improved dye stability and performance for various industries.
* Development of new analytical techniques utilizing its unique properties.
* Discovery of new applications in materials science and biotechnology.

Therefore, this specific azo dye serves as an example of how chemical compounds can be valuable tools in multiple scientific fields.

1-amino-9,10-dihydro-9,10-dioxo-4-(phenylamino)-2-anthracenesulfonic acid: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID22916
CHEMBL ID1206272
SCHEMBL ID791019
MeSH IDM0537735

Synonyms (35)

Synonym
2-anthracenesulfonic acid, 1-amino-9,10-dihydro-9,10-dioxo-4-(phenylamino)-
1-amino-4-anilino-9,10-dioxo-2-anthracenylsulfonic acid, sodium salt
1-amino-4-anilino-9,10-dioxo-anthracene-2-sulfonic acid
1-amino-9,10-dioxo-4-(phenylamino)-9,10-dihydroanthracene-2-sulfonic acid
STK367473
nsc167429
1-amino-9,10-dioxo-4-(phenylamino)-2-anthracenesulfonic acid
nsc-167429
c.i. acid blue 25 free acid
2-anthracenesulfonic acid,10-dihydro-9,10-dioxo-4-(phenylamino)-
2786-71-2
AKOS001591131
1-amino-4-anilino-9,10-dioxoanthracene-2-sulfonic acid
CHEMBL1206272
einecs 220-508-8
unii-p44r6g887x
c.i. 62055
1-amino-4-anilino-2-anthraquinonesulfonic acid
nsc 167429
p44r6g887x ,
1-amino-4-anilino-9,10-dihydro-9,10-dioxo-2-anthracenesulphonic acid
1-amino-9,10-dihydro-9,10-dioxo-4-(phenylamino)-2-anthracenesulfonic acid
DTXSID9045055
SCHEMBL791019
1-amino-4-anilino-9,10-2h-9,10-dioxo-2-anthracenesulphonic acid
W-109824
acid blue 25 parent
1-amino-4-anilino-9,10-anthraquinone-2-sulfonic acid
ci acid blue 25 free acid
2-anthracenesulfonic acid, 1-amino-4-anilino-9,10-dihydro-9,10-dioxo-
acid blue 25 free acid
sr-01000078282
SR-01000078282-1
1-amino-4-anilino-9,10-dihydro-9,10-dioxo-2-anthracenesulfonic acid
Q27286114

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Removal efficiency increased with increase of IJSP dosage but decreased with increase of temperature."( Indian jujuba seed powder as an eco-friendly and a low-cost biosorbent for removal of acid blue 25 from aqueous solution.
Krishna, LS; Reddy, AS; Reddy, AV; Taha, MR; Zuhairi, WY, 2014)		0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID1465414Antagonist activity at wild type P2Y2 receptor Y114F mutant (unknown origin) expressed in human 1321N1 astrocytoma cells assessed as inhibition of UTP-induced increase in intracellular calcium mobilization preincubated for 30 mins followed by UTP addition2017Journal of medicinal chemistry, 10-26, Volume: 60, Issue:20
Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y
AID1465413Antagonist activity at wild type P2Y2 receptor Y114A mutant (unknown origin) expressed in human 1321N1 astrocytoma cells assessed as inhibition of UTP-induced increase in intracellular calcium mobilization preincubated for 30 mins followed by UTP addition2017Journal of medicinal chemistry, 10-26, Volume: 60, Issue:20
Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y
AID1465415Antagonist activity at wild type P2Y2 receptor R194H mutant (unknown origin) expressed in human 1321N1 astrocytoma cells assessed as inhibition of UTP-induced increase in intracellular calcium mobilization preincubated for 30 mins followed by UTP addition2017Journal of medicinal chemistry, 10-26, Volume: 60, Issue:20
Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y
AID1465412Antagonist activity at wild type P2Y2 receptor (unknown origin) expressed in human 1321N1 astrocytoma cells assessed as inhibition of UTP-induced increase in intracellular calcium mobilization preincubated for 30 mins followed by UTP addition measured aft2017Journal of medicinal chemistry, 10-26, Volume: 60, Issue:20
Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (9.52)29.6817
2010's17 (80.95)24.3611
2020's2 (9.52)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.56 (24.57)
Research Supply Index3.14 (2.92)
Research Growth Index4.70 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
sulfuric acid
sulfuric acid : A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom.		2.0510sulfur oxoacidcatalyst
cetylpyridinium
Cetylpyridinium: Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.		2.0610pyridinium ion
methylene blue
Methylene Blue: A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.. methylene blue : An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties.		2.1310organic chloride saltacid-base indicator;
antidepressant;
antimalarial;
antimicrobial agent;
antioxidant;
cardioprotective agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 4.6.1.2 (guanylate cyclase) inhibitor;
fluorochrome;
histological dye;
neuroprotective agent;
physical tracer
uridine triphosphate
Uridine Triphosphate: Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.		2.1510pyrimidine ribonucleoside 5'-triphosphate;
uridine 5'-phosphate		Escherichia coli metabolite;
mouse metabolite
isoprene
isoprene: used in manufacture of ''synthetic'' rubber, butyl rubber; copolymer in production of elastomers; structure. isoprene : A hemiterpene with the formula CH2=C(CH3)CH=CH2; the monomer of natural rubber and a common structure motif to the isoprenoids, a large class of other naturally occurring compounds.		2.0510alkadiene;
hemiterpene;
volatile organic compound		plant metabolite
sodium carbonate
sodium carbonate: used topically for dermatitides, mouthwash, vaginal douche; veterinary use as emergency emetic; RN given refers to carbonic acid, di-Na salt; structure		2.0510carbonate salt;
organic sodium salt
congo red
Congo Red: An acid dye used in testing for hydrochloric acid in gastric contents. It is also used histologically to test for AMYLOIDOSIS.. Congo Red : An indicator dye that is blue-violet at pH 3.0 and red at pH 5.0.		2.0510bis(azo) compound
carbonates
Carbonates: Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed). carbonates : Organooxygen compounds that are salts or esters of carbonic acid, H2CO3.		2.0510carbon oxoanion
titanium
Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.		2.4920titanium group element atom
chromium
Chromium: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.. chromium ion : An chromium atom having a net electric charge.. chromium atom : A chromium group element atom that has atomic number 24.		2.110chromium group element atom;
metal allergen		micronutrient
tricalcium phosphate
tricalcium phosphate: a form of tricalcium phosphate used as bioceramic bone replacement material; see also records for alpha-tricalcium phosphate, beta-tricalcium phosphate, calcium phosphate; apatitic tricalcium phosphate Ca9(HPO4)(PO4)5(OH) is the calcium orthophosphate leading to beta tricalcium phosphate Ca3(PO4)2 (b-TCP). calcium phosphate : A calcium salt composed of calcium and phosphate/diphosphate ions; present in milk and used for the mineralisation of calcified tissues.		2.0710calcium phosphate
titanium dioxide
titanium dioxide: used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure. titanium dioxide : A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.		2.4920titanium oxidesfood colouring
chromium
chromium hexavalent ion: a human respiratory carcinogen		2.110chromium cation;
monoatomic hexacation
ethylhexadecyldimethylammonium
ethylhexadecyldimethylammonium: a disinfectant		2.0610
lissamine rhodamine b
lissamine rhodamine B: RN given refers to parent cpd; Lissamine Rhodamine B refers to Na salt		2.0510
methylthio-adp
[no description available]		2.1510
2-methylthio-atp
2-methylthio-ATP: purinergic receptors agonist; relaxes mammalian gut preparations; structure given in first source		2.1510
cellulose
DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.		2.1310glycoside
chitosan
[no description available]		2.8330
mrs2500
[no description available]		2.1510
ConditionIndicatedRelationship StrengthStudiesTrials
Plasmodium falciparum Malaria
[description not available]		02.110
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.		02.110