1-acetyl-N-propyl-3,4-dihydro-2H-quinoline-6-sulfonamide is a **synthetic organic compound** that belongs to the class of **quinoline sulfonamides**.
**Structure and Properties:**
* **Quinoline core:** The compound contains a quinoline ring, which is a bicyclic aromatic system.
* **Sulfonamide group:** A sulfonamide group (-SO2NH-) is attached to the sixth position of the quinoline ring.
* **Acetyl group:** An acetyl group (CH3CO-) is attached to the first position of the quinoline ring.
* **N-Propyl group:** A propyl group (CH3CH2CH2-) is attached to the nitrogen atom of the sulfonamide group.
**Research Significance:**
This compound is of interest in research due to its potential **biological activity and pharmacological applications**. While specific research on this exact compound might be limited, the general class of quinoline sulfonamides has been investigated for various therapeutic applications, including:
* **Antimicrobial activity:** Quinoline sulfonamides can exhibit antibacterial and antifungal properties. They can interfere with bacterial growth and metabolism, making them potential candidates for the development of new antibiotics.
* **Anti-inflammatory activity:** Some quinoline sulfonamides have shown anti-inflammatory effects, potentially targeting pathways involved in inflammation. This could lead to the development of drugs for treating inflammatory conditions.
* **Anticancer activity:** Quinoline sulfonamides have been investigated for their potential to inhibit cancer cell growth and proliferation. They might interact with specific targets within cancer cells, leading to cell death or halting cancer progression.
* **Neuroprotective activity:** Some studies have suggested that certain quinoline sulfonamides may have neuroprotective effects, potentially protecting neurons from damage and promoting neurological function.
**Important Considerations:**
* **Specificity and Mechanism:** The specific biological activity and mechanism of action of 1-acetyl-N-propyl-3,4-dihydro-2H-quinoline-6-sulfonamide are unknown.
* **Preclinical research:** Further research is needed to determine the specific properties of this compound, including its potential therapeutic applications, toxicity, and pharmacokinetic characteristics.
* **Clinical trials:** Extensive preclinical and clinical trials are required before any quinoline sulfonamide can be considered for use as a drug.
**In summary:** 1-acetyl-N-propyl-3,4-dihydro-2H-quinoline-6-sulfonamide is a synthetic compound with a potential for pharmacological activity due to its structure and membership in the quinoline sulfonamide class. Further research is needed to explore its specific properties and potential applications.
ID Source | ID |
---|---|
PubMed CID | 3243437 |
CHEMBL ID | 1571528 |
CHEBI ID | 105332 |
Synonym |
---|
CHEMDIV3_009189 |
IDI1_027099 |
1-acetyl-n-propyl-1,2,3,4-tetrahydroquinoline-6-sulfonamide |
smr000026847 |
MLS000045255 , |
CHEBI:105332 |
AKOS001823995 |
HMS1499B15 |
1-acetyl-n-propyl-3,4-dihydro-2h-quinoline-6-sulfonamide |
HMS2315H22 |
CCG-28919 |
1-ethanoyl-n-propyl-3,4-dihydro-2h-quinoline-6-sulfonamide |
bdbm74638 |
cid_3243437 |
CHEMBL1571528 |
Q27183054 |
Z133628898 |
Class | Description |
---|---|
quinolines | A class of aromatic heterocyclic compounds each of which contains a benzene ring ortho fused to carbons 2 and 3 of a pyridine ring. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 22.3872 | 0.0112 | 12.4002 | 100.0000 | AID1030 |
chromobox protein homolog 1 | Homo sapiens (human) | Potency | 79.4328 | 0.0060 | 26.1688 | 89.1251 | AID540317 |
nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 10.3225 | 0.0041 | 9.9848 | 25.9290 | AID504444 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b | Homo sapiens (human) | EC50 (µMol) | 500.0000 | 0.9181 | 41.9368 | 121.5000 | AID435026 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (14.29) | 29.6817 |
2010's | 5 (71.43) | 24.3611 |
2020's | 1 (14.29) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.20) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 7 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |