Page last updated: 2024-11-07

1-acetyl-3,2-toluyl-5-fluorouracil

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

atofluding: anticancer drug in Phase III clinical trial (7/2003); spelled both ways in the article [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID126342
CHEMBL ID282865
SCHEMBL ID475623
MeSH IDM0073689

Synonyms (18)

Synonym
1-acetyl-5-fluoro-3-(2-methylbenzoyl)-2,4-(1h,3h)-pyrimidinedione
n(sub 1)-acetyl-n(sub 3)-o-toluyl-5-fluorouracil
1-acetyl-3,2-toluyl-5-fluorouracil
brn 5598480
2,4(1h,3h)-pyrimidinedione, 1-acetyl-5-fluoro-3-(2-methylbenzoyl)-
atofluding
a-ot
CHEMBL282865
1-acetyl-5-fluoro-3-(2-methylbenzoyl)pyrimidine-2,4-dione
71861-76-2
1-acetyl-3-o-toluyl-5-fluorouracil
DTXSID00222129
SCHEMBL475623
1-acetyl-5-fluoro-3-(2-methylphenyl)uracil
HY-U00130
CS-7167
AKOS040732223
a-?ot-?fu

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The same dosage of combine drugs were used in the two groups."( [Phase III clinical study of a new anticancer drug atofluding].
Feng, FY; Han, J; Li, L; Li, Q; Sui, GJ; Wang, PH; Zhang, Y; Zhang, YC; Zhang, ZH; Zhou, MZ; Zhu, YG, 2002
)
0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID136876Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 300 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137190Antitumor activity against Meth A cells in female BDF1 mice expressed as percent T/C at dose 100 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137197Antitumor activity against P-388 Leukemia in female BDF1 mice expressed as percent T/C at dose 50 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID136875Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 200 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137192Antitumor activity against Meth A cells in female BDF1 mice expressed as percent T/C at dose 50 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137186Antitumor activity against MH 134 cells in female BDF1 mice expressed as percent T/C at dose 200 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137196Percentage change in median survival time of P388 (leukemia) inoculated female mice following 25 mg/kg i.p.1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137195Percentage change in median survival time of P388 (leukemia) inoculated female mice following 200 mg/kg i.p.1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137189Antitumor activity against MH 134 cells in female BDF1 mice expressed as percent T/C at dose 50 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID136874Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 100 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137185Antitumor activity against MH 134 cells in female BDF1 mice expressed as percent T/C at dose 100 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID136877Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 50 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137193Percentage change in median survival time of P388 (leukemia) inoculated female mice following 100 mg/kg i.p.1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137191Antitumor activity against Meth A cells in female BDF1 mice expressed as percent T/C at dose 200 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.19

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.19 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.19)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (20.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]