Compounds > 1-acetyl-3,2-toluyl-5-fluorouracil
Page last updated: 2024-12-07

1-acetyl-3,2-toluyl-5-fluorouracil

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-Acetyl-3,2-toluyl-5-fluorouracil is a chemical compound that doesn't have widespread recognition or established importance in current research.

Here's why:

* **No Established Research:** There's no significant body of research or publications readily available that focus specifically on this compound.
* **Lack of Common Usage:** It's highly unlikely that this specific compound has been extensively studied or is used in any established research fields.
* **Possible Misnomer:** It's possible the name is a typographical error or misrepresentation of a different, more commonly studied compound.

**How to Find More Information:**

1. **Double-check the Chemical Name:** Ensure the name is accurate and hasn't been mistyped.
2. **Consult Chemical Databases:** Search reputable chemical databases like PubChem or SciFinder to see if this compound has any associated information.
3. **Contact Research Institutions:** If you have a specific research context in mind, contact relevant universities or research institutions to inquire about potential research involving this compound.

It's important to remember that scientific research is constantly evolving, so while this compound may not have current recognition, its potential value could be explored further with additional research.

atofluding: anticancer drug in Phase III clinical trial (7/2003); spelled both ways in the article [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID126342
CHEMBL ID282865
SCHEMBL ID475623
MeSH IDM0073689

Synonyms (18)

Synonym
1-acetyl-5-fluoro-3-(2-methylbenzoyl)-2,4-(1h,3h)-pyrimidinedione
n(sub 1)-acetyl-n(sub 3)-o-toluyl-5-fluorouracil
1-acetyl-3,2-toluyl-5-fluorouracil
brn 5598480
2,4(1h,3h)-pyrimidinedione, 1-acetyl-5-fluoro-3-(2-methylbenzoyl)-
atofluding
a-ot
CHEMBL282865
1-acetyl-5-fluoro-3-(2-methylbenzoyl)pyrimidine-2,4-dione
71861-76-2
1-acetyl-3-o-toluyl-5-fluorouracil
DTXSID00222129
SCHEMBL475623
1-acetyl-5-fluoro-3-(2-methylphenyl)uracil
HY-U00130
CS-7167
AKOS040732223
a-?ot-?fu

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The same dosage of combine drugs were used in the two groups."( [Phase III clinical study of a new anticancer drug atofluding].
Feng, FY; Han, J; Li, L; Li, Q; Sui, GJ; Wang, PH; Zhang, Y; Zhang, YC; Zhang, ZH; Zhou, MZ; Zhu, YG, 2002)		0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID136876Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 300 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137190Antitumor activity against Meth A cells in female BDF1 mice expressed as percent T/C at dose 100 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137197Antitumor activity against P-388 Leukemia in female BDF1 mice expressed as percent T/C at dose 50 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID136875Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 200 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137192Antitumor activity against Meth A cells in female BDF1 mice expressed as percent T/C at dose 50 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137186Antitumor activity against MH 134 cells in female BDF1 mice expressed as percent T/C at dose 200 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137196Percentage change in median survival time of P388 (leukemia) inoculated female mice following 25 mg/kg i.p.1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137195Percentage change in median survival time of P388 (leukemia) inoculated female mice following 200 mg/kg i.p.1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137189Antitumor activity against MH 134 cells in female BDF1 mice expressed as percent T/C at dose 50 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID136874Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 100 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137185Antitumor activity against MH 134 cells in female BDF1 mice expressed as percent T/C at dose 100 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID136877Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 50 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137193Percentage change in median survival time of P388 (leukemia) inoculated female mice following 100 mg/kg i.p.1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
AID137191Antitumor activity against Meth A cells in female BDF1 mice expressed as percent T/C at dose 200 mg/kg1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.19

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.19 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.19)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (20.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		4.4751nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
tegafur
[no description available]		1.9510organohalogen compound;
pyrimidines
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		01.9510
Experimental Neoplasms
[description not available]		01.9510
Experimental Hepatoma
[description not available]		01.9610
Leukocytopenia
[description not available]		03.3911
Benign Neoplasms
[description not available]		03.3911
Thrombopenia
[description not available]		03.3911
Anemia
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.		03.3911
Leukopenia
A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).		03.3911
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.3911
Thrombocytopenia
A subnormal level of BLOOD PLATELETS.		03.3911
Cancer of Stomach
[description not available]		02.4420
Stomach Neoplasms
Tumors or cancer of the STOMACH.		02.4420
Carcinoma, Anaplastic
[description not available]		02.0310
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.0310