Compounds > 1-ac-trp-2-(4-cl-phe)-3-trp-6-lys-10-alanh2-lhrh
Page last updated: 2024-11-13

1-ac-trp-2-(4-cl-phe)-3-trp-6-lys-10-alanh2-lhrh

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

MI 1544: LHRH antagonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID25078117
MeSH IDM0120020

Synonyms (15)

Synonym
lhrh,-n-(acetyltryptophyl)(1)-4-chlorophenylalanyl(2)-tryptophyl(3)-lysyl(6)-alaninamide(10)-
87565-51-3
mi-1544
mi 1544
gnrh,n-ac-trp(1)-(4-cl-phe)(2)-trp(3)-lys(6)-alanh2(10)-
1-ac-trp-2-(4-cl-phe)-3-trp-6-lys-10-alanh2-lhrh
d-alaninamide, n-acetyl-d-tryptophyl-4-chloro-d-phenylalanyl-d-tryptophyl-l-seryl-l-tyrosyl-d-lysyl-l-leucyl-l-arginyl-l-prolyl-, (6r-(6alpha,7beta(z)))-
d-alaninamide, n-acetyl-d-tryptophyl-4-chloro-d-phenylalanyl-d-trptophyl-l-seryl-l-tyrosyl-d-lysyl-l-leucyl-l-arginyl-l-prolyl-
gnrh, n-ac-trp(1)-(4-cl-phe)(2)-trp(3)-lys(6)-alanh2(10)-
1-ac-trp-2-cpa-3-trp-6-lys-10-alanh2-lhrh
lhrh, n-ac-trp(1)-4-cl-phe(2)-trp(3)-lys(6)-alanh(2)(10)-
ac-d-trp(1,3)-d-cpa(2)-d-lys(6)-d-ala(10)-lh-rh
DTXSID80893856
(s)-n-((r)-1-((r)-2-acetamido-3-(1h-indol-3-yl)propanamido)-1-oxopropan-2-yl)-1-(((r)-2-amino-3-(4-chlorophenyl)propanoyl)-d-tryptophyl-l-seryl-l-tyrosyl-d-lysyl-l-leucyl-l-arginyl)pyrrolidine-2-carboxamide
d-alaninamide, n-acetyl-d-tryptophyl-4-chloro-d-phenylalanyl-d-tryptophyl-l-seryl-l-tyrosyl-d-lysyl-l-leucyl-l-arginyl-l-prolyl-

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" A dose-response study in the EpiSkin assay indicated that this molecule still has a significant skin irritation potential, which may generate the weak positive signal in the LLNA."( Use of in vitro testing to identify an unexpected skin sensitizing impurity in a commercial product: a case study.
Ellis, G; Emter, R; Gfeller, H; Natsch, A, 2010)		0.36
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (5.88)18.7374
1990's7 (41.18)18.2507
2000's4 (23.53)29.6817
2010's2 (11.76)24.3611
2020's3 (17.65)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.16 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index5.16 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gamma-aminobutyric acid
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.		2.0810amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
pyrrolidonecarboxylic acid
Pyrrolidonecarboxylic Acid: A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.. 5-oxo-L-proline : An optically active form of 5-oxoproline having L-configuration.		2.42205-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid		algal metabolite
1,1-diphenyl-2-picrylhydrazyl
1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)		2.0810
ovurelin
ovurelin: GnRH agonist		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
Diathesis
[description not available]		02.2510
Allergic Contact Dermatitis
[description not available]		02.0510
Dermatitis, Allergic Contact
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.		02.0510
Acute Promyelocytic Leukemia
[description not available]		02.0810
Leukemia, Promyelocytic, Acute
An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.		02.0810
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9610
Breast Cancer
[description not available]		02.940
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.940
Cancer of Prostate
[description not available]		01.9910
Cancer of Endometrium
[description not available]		02.420
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		01.9910
Endometrial Neoplasms
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.		02.420
Disease Exacerbation
[description not available]		01.9910
Experimental Mammary Neoplasms
[description not available]		01.9910
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.		02.0110
Cancer of the Thyroid
[description not available]		02.0110
Thyroid Neoplasms
Tumors or cancer of the THYROID GLAND.		02.0110