1,8-naphthalenedicarboxylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,8-naphthalenedicarboxylic acid is a white solid that is sparingly soluble in water. It is a dicarboxylic acid that can be synthesized by the oxidation of 1,8-dimethylnaphthalene. 1,8-naphthalenedicarboxylic acid is used as a precursor to polymers and as a starting material for the synthesis of other organic compounds. It is also a potential building block for the construction of functionalized materials. The compound has been studied for its potential applications in organic electronics and as a catalyst for organic reactions. It exhibits fluorescence and is under investigation for its potential use in fluorescent probes and sensors.'

1,8-naphthalenedicarboxylic acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	68204
SCHEMBL ID	68291
MeSH ID	M0198114

Synonyms (30)

Synonym
1,8-naphthalic acid
nsc37065
518-05-8
naphthalic acid
1,8-naphthalenedicarboxylic acid
nsc-37065
NCI60_008003
AE-641/05536032
SR-01000645150-1
AC-10622
AKOS000278046
HMS1661D04
naphthalene-1,8-dicarboxylic acid
einecs 208-247-8
u1t26yew8c ,
unii-u1t26yew8c
nsc 37065
STK525477
A828792
CCG-56176
naphthalic acid [mi]
SCHEMBL68291
naphthalsaure
HRRDCWDFRIJIQZ-UHFFFAOYSA-N
1,8-naphthalicacid
bio1g11
DTXSID90199730
FT-0727282
Q27290570
CS-0368272

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay ID	Title	Year	Journal	Article
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299	A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis	2010	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21	Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1159607	Screen for inhibitors of RMI FANCM (MM2) intereaction	2016	Journal of biomolecular screening, Jul, Volume: 21, Issue:6	A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (30.00)	18.2507
2000's	2 (20.00)	29.6817
2010's	4 (40.00)	24.3611
2020's	1 (10.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	19.85 (24.57)
Research Supply Index	2.40 (2.92)
Research Growth Index	4.62 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (19.85)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
scriptaid scriptide: provokes translocation of GLUT4 to increase glucose uptake; structure in first source	2.31	1	isoquinolines
galactose galactopyranose : The pyranose form of galactose.	2.02	1	D-galactose; galactopyranose	Escherichia coli metabolite; mouse metabolite
acenaphthylene acenaphthylene: RN given refers to parent cpd. acenaphthylene : A ortho- and peri-fused tricyclic hydrocarbon that occurs in coal tar.	2.03	1	acenaphthylenes; ortho- and peri-fused polycyclic arene; ortho- and peri-fused tricyclic hydrocarbon
naphthalimides Naphthalimides: Compounds with three fused rings that appear like a naphthalene fused to piperidone or like a benz(de)isoquinoline-1,3-dione (not to be confused with BENZYLISOQUINOLINES which have a methyl separating the naphthyl from the benzyl rings). Members are CYTOTOXINS.	2.31	1
sm 1213 amiprilose: immunopotentiator	1.99	1
2-chloro-1-methylpyridinium 2-chloro-1-methylpyridinium: coupling reagent for peptide synthesis	1.99	1
glucosamine D-glucosamine : An amino sugar whose structure comprises D-glucose having an amino substituent at position 2.. 2-amino-2-deoxy-D-glucopyranose : A D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2.	1.99	1	D-glucosamine	Escherichia coli metabolite; geroprotector; mouse metabolite
D-fructopyranose [no description available]	2.02	1	cyclic hemiketal; D-fructose; fructopyranose	sweetening agent
ribose ribopyranose : The pyranose form of ribose.	1.99	1	D-ribose; ribopyranose

Condition	Relationship Strength	Studies
Encephalitis, Polio [description not available]	2.06	1
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	2.06	1
Anemia, Fanconi [description not available]	2.13	1
Fanconi Anemia Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)	2.13	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	1.99	1

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