Compounds > 1,6-pyrenequinone
Page last updated: 2024-11-05

1,6-pyrenequinone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,6-Pyrenequinone is a polycyclic aromatic ketone that has been shown to be a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase. It is also known to have anti-inflammatory and anticancer properties. The synthesis of 1,6-pyrenequinone involves the oxidation of pyrene, a polycyclic aromatic hydrocarbon. Research into this compound is driven by its potential as a therapeutic agent for a variety of diseases.'

1,6-pyrenequinone: RN given refers to cpd with locants for oxo moiety in positions 1 & 6 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID15699
CHEBI ID81608
SCHEMBL ID1310003
MeSH IDM0098140

Synonyms (22)

Synonym
eu5go38i7h ,
unii-eu5go38i7h
pyrene-1,6-dione
ccris 5485
brn 1963133
einecs 217-238-8
nsc 142616
nsc142616
1,6-pyrenedione
pyrenequinone
1785-51-9
nsc-142616
3,8-pyrenequinone
1,6-pyrenequinone
3,8-pyrenedione
C18257
HMS1649I09
SCHEMBL1310003
CHEBI:81608
DTXSID4061967
Q27155495
1,6-dihydropyrene-1,6-dione
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
pyrenes
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (14.29)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.59

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.59 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.59)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
2-acetylaminofluorene
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.		1.96102-acetamidofluorenesantimitotic;
carcinogenic agent;
epitope;
mutagen
1,8-pyrenequinone
1,8-pyrenequinone: RN given refers to cpd with locants for oxo moiety in positions 1 & 8		3.0950pyrenes
benzo(a)pyrene-3,6-quinone
[no description available]		1.9810
1-hydroxypyrene
1-hydroxypyrene: pyrene metabolite; RN given refers to parent cpd		2.0710pyrenes
1-nitropyrene
[no description available]		2.0710nitroarenecarcinogenic agent
pyrene
pyrene: structure in Merck Index, 9th ed, #7746. pyrene : An ortho- and peri-fused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system.		210ortho- and peri-fused polycyclic arenefluorescent probe;
persistent organic pollutant
1-nitrosopyrene
1-nitrosopyrene: structure given in first source		2.0710
nadp
[no description available]		210
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0210
Abnormalities, Autosome
[description not available]		01.9810