Compounds > 1,5-diazabicyclo(4.3.0)non-5-ene
Page last updated: 2024-12-07

1,5-diazabicyclo(4.3.0)non-5-ene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,5-diazabicyclo(4.3.0)non-5-ene: inhibitor of indolamine-N-methyltransferase; RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID76349
CHEMBL ID3303308
CHEBI ID183972
SCHEMBL ID2927
MeSH IDM0061395

Synonyms (56)

Synonym
1,5-diazabicyclo-[4.3.0]non-5-ene
unii-978m4ol12q
einecs 221-087-3
978m4ol12q ,
nsc 118106
pyrrolo[1,2-a]pyrimidine, 2,3,4,6,7,8-hexahydro-
1,5-diazabicyclo[4.3.0]non-5-ene
3001-72-7
nsc118106
nsc-118106
nbu ,
inchi=1/c7h12n2/c1-3-7-8-4-2-6-9(7)5-1/h1-6h
1,5-diazabicyclo[4.3.0]non-5-ene, 98%
1,5-diazabicyclo(4.3.0)non-5-ene
1,5-diazabicyclo[4.3.0]-5-nonene
D1313
1,5-diazabicyclo[4.3.0]-non-5-ene
2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidine
CHEBI:183972
2h,3h,4h,6h,7h,8h-pyrrolo[1,2-a]pyrimidine
1,5-diazabicyclo[4,3,0]non-5-ene
A820145
AKOS005206778
FT-0606950
CHEMBL3303308
SCHEMBL2927
1,5-diazabicyclo(4.3.0)non-5-ene [mi]
2,3,4,6,7,8-hexahydropyrrolo(1,2-a)pyrimidine
AKOS025243303
1,5-diazabicyclo-[4,3,0]-non-5-ene
1,5-diaza-bicyclo[4.3.0] non-5-ene
1,5-diazabicyclo[4.3.0] -5-nonene
1,5-diazabicyclo-[4.3.0] non-5-ene
2,3,4,6,7,8-hexahydro-pyrrolo[1,2-a]pyrimidine
1,5-diazabicyclo [4.3.0]-5-nonene
1,5-diazabicyclo -[4.3.0]non-5-ene
1,5-diaza- bicylo-[4,3,0]-non-5-ene
1,5-diazabicyclo[4,3,0]-5-nonene
1,5-diazabicyclo [4.3.0]non-5-ene
1,5-diazabicyclo(4,3,0)non-5-ene
1,5-diaza-bicyclo[4.3.0]non-5-ene
Q-101285
2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidine #
mfcd00005554
F8889-2155
DTXSID10184087
1,5-diazabicyclo[4.3.0]non-5-ene, purum, >=98.0% (gc)
Q307070
2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidine pyrrolo[1,2-a]pyrimidine, 2,3,4,6,7,8-hexahydro- pyrrolidino[1,2:a]1,4,5,6-tetrahydro-pyrimidine
BCP30896
STL185618
C93461
2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidine pound dbn pound(c)
CS-W016569
EN300-39944
Z406355328
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
pyrrolopyrimidine
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (11.11)18.7374
1990's0 (0.00)18.2507
2000's3 (33.33)29.6817
2010's4 (44.44)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.87 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.38 (4.65)
Search Engine Demand Index31.58 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bromide
Bromides: Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)		2.0110halide anion;
monoatomic bromine
hydrobromic acid
Hydrobromic Acid: Hydrobromic acid (HBr). A solution of hydrogen bromide gas in water.. hydrobromide : Salts formally resulting from the reaction of hydrobromic acid with an organic base.. hydrogen bromide : A diatomic molecule containing covalently bonded hydrogen and bromine atoms.		2.0110gas molecular entity;
hydrogen halide;
mononuclear parent hydride		mouse metabolite
1-butanol
1-Butanol: A four carbon linear hydrocarbon that has a hydroxy group at position 1.. butan-1-ol : A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes.		2.0810alkyl alcohol;
primary alcohol;
short-chain primary fatty alcohol		human metabolite;
mouse metabolite;
protic solvent
imidazole
imidazole: RN given refers to parent cpd. 1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.		2.1310imidazole
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		2.0610alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
tolmetin
Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.. tolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.		2.0510aromatic ketone;
monocarboxylic acid;
pyrroles		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-steroidal anti-inflammatory drug
4-toluenesulfonic acid
4-toluenesulfonic acid: RN given refers to parent cpd; other RNs in 9th CI Form Index. toluene-4-sulfonic acid : An arenesulfonic acid that is benzenesulfonic acid in which the hydrogen at position 4 is replaced by a methyl group.		2.0810arenesulfonic acid;
toluenes
acetonitrile
acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.		2.0610aliphatic nitrile;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
NMR chemical shift reference compound;
polar aprotic solvent
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		2.0510pyrrole;
secondary amine
triethylamine
[no description available]		2.0610tertiary amine
triethylenediamine
triethylenediamine: RN given refers to parent cpd. triethylenediamine : An organic heterobicylic compound that is piperazine with an ethane-1,2-diyl group forming a bridge between N1 and N4. It is typically used as a catalyst in polymerization reactions.		2.0610bridged compound;
diamine;
saturated organic heterobicyclic parent;
tertiary amino compound		antioxidant;
catalyst;
reagent
pyridine n-oxide
pyridine N-oxide: RN given refers to parent cpd. pyridine N-oxide : The pyridine N-oxide derived from the parent pyridine. It is a drug metabolite of the antihypertensive agent pinacidil.		2.3110pyridine N-oxidesdrug metabolite
1,8-diazabicyclo(5.4.0)undec-7-ene
[no description available]		2.6830
retinol
Vitamin A: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.. vitamin A : Any member of a group of fat-soluble retinoids produced via metabolism of provitamin A carotenoids that exhibit biological activity against vitamin A deficiency. Vitamin A is involved in immune function, vision, reproduction, and cellular communication.. all-trans-retinol : A retinol in which all four exocyclic double bonds have E- (trans-) geometry.. retinol : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraen-1-ol substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).		2.0110retinol;
vitamin A		human metabolite;
mouse metabolite;
plant metabolite
tacrolimus
Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.. tacrolimus (anhydrous) : A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.		2.0810macrolide lactambacterial metabolite;
immunosuppressive agent
selenium
Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.		2.0210chalcogen;
nonmetal atom		micronutrient
oligonucleotides
[no description available]		1.9510
cellulose
DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.		2.3110glycoside
tert-butoxide, potassium
[no description available]		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials