1,4-phenylene diisocyanide profile

1,4-phenylene diisocyanide, also known as **1,4-dicyanobenzene**, is a **diisocyanide** molecule with the chemical formula **C8H4N2**. It has two **isocyanide groups (-NC)** attached to a **para-phenylene ring**.

This molecule is considered a **highly reactive building block** in organic synthesis and is particularly interesting for several reasons:

**Importance in Research:**

* **Versatile Synthon:** 1,4-phenylene diisocyanide can be used to synthesize a variety of complex organic compounds, including polymers, dendrimers, and heterocycles.
* **Metal Coordination:** The isocyanide groups can coordinate to metal ions, creating interesting metal complexes with potential applications in catalysis and materials science.
* **Organic Electronics:** The molecule's conjugated structure and the presence of electron-withdrawing isocyanide groups make it a promising candidate for use in organic electronics, such as organic light-emitting diodes (OLEDs) and organic solar cells.
* **Photochemistry:** 1,4-phenylene diisocyanide exhibits interesting photochemical properties, including photoisomerization and photodimerization. This makes it relevant for research in photochemistry, photocatalysis, and light-harvesting systems.
* **Click Chemistry:** The isocyanide group can be used in click chemistry reactions, allowing for the rapid and efficient synthesis of complex molecules.

**Overall, 1,4-phenylene diisocyanide offers a diverse range of potential applications in various scientific fields, making it a valuable research tool.**

1,4-phenylene diisocyanide: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	2771554
SCHEMBL ID	409015
MeSH ID	M0504069

Synonym
1,4-diisocyanobenzene
inchi=1/c8h4n2/c1-9-7-3-5-8(10-2)6-4-7/h3-6
935-16-0
FT-0633142
1,4-phenylene diisocyanide
GEO-02803
AKOS015913089
SCHEMBL409015
DTXSID10377957
W-200529
1,4-phenylenediisocyanide
4-isocyanophenylisocyanide
mfcd00012383
AS-81211

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (28.57)	29.6817
2010's	4 (57.14)	24.3611
2020's	1 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetic acid Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.	2.08	1	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent
ammonium hydroxide azane : Saturated acyclic nitrogen hydrides having the general formula NnHn+2.	2.08	1	azane; gas molecular entity; mononuclear parent hydride	EC 3.5.1.4 (amidase) inhibitor; metabolite; mouse metabolite; neurotoxin; NMR chemical shift reference compound; nucleophilic reagent; refrigerant
benzene [no description available]	2.05	1	aromatic annulene; benzenes; volatile organic compound	carcinogenic agent; environmental contaminant; non-polar solvent
iodine Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.. diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..	2.6	1	diatomic iodine	nutrient
nickel Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.	2.02	1	metal allergen; nickel group element atom	epitope; micronutrient
cyanides Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.. cyanides : Salts and C-organyl derivatives of hydrogen cyanide, HC#N.. isocyanide : The isomer HN(+)#C(-) of hydrocyanic acid, HC#N, and its hydrocarbyl derivatives RNC (RN(+)#C(-)).. cyanide : A pseudohalide anion that is the conjugate base of hydrogen cyanide.	2.98	4	pseudohalide anion	EC 1.9.3.1 (cytochrome c oxidase) inhibitor
acetonitrile acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.	2.06	1	aliphatic nitrile; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; NMR chemical shift reference compound; polar aprotic solvent
terephthalic acid terephthalic acid: RN given refers to 1,4-benzenedicarboxylic acid. terephthalic acid : A benzenedicarboxylic acid carrying carboxy groups at positions 1 and 4. One of three possible isomers of benzenedicarboxylic acid, the others being phthalic and isophthalic acids.	7.02	1	benzenedicarboxylic acid
platinum Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae.	2.02	1	elemental platinum; nickel group element atom; platinum group metal atom
silver Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.	2.08	1	copper group element atom; elemental silver	Escherichia coli metabolite
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	2.47	2	copper group element atom; elemental gold
sulfur Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.	2.06	1	chalcogen; nonmetal atom	macronutrient

Condition	Indicated	Relationship Strength	Studies	Trials
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	0	2.02	1	0

1,4-phenylene diisocyanide

Description

Cross-References

Synonyms (14)

Research

Studies (7)

Market Indicators

Research Demand Index: 17.65

Study Types