1,4-bis(3-indolyl)-2,3-diaza-1,3-butadiene, also known as **bis(indolyl)diazabutadiene** (BID), is a **synthetic organic compound**. It's important for research because:
* **It's a versatile building block for complex organic molecules.** BID is used as a reagent in organic synthesis, particularly for constructing indole-containing compounds. Indoles are a crucial structural motif found in many biologically active molecules, such as the amino acid tryptophan and the alkaloid serotonin.
* **It serves as a model system for studying the properties of indole derivatives.** BID's structural features allow researchers to investigate the electronic and chemical properties of indole rings, which is crucial for understanding the behavior of indole-containing compounds in different environments.
* **It has potential applications in various research fields.** These include:
* **Materials Science:** BID can be used to create new materials with specific optical and electronic properties, potentially leading to applications in optoelectronics and sensors.
* **Drug Discovery:** BID can be used as a starting material to synthesize novel compounds with potential therapeutic activity.
* **Organic Chemistry:** BID is a valuable tool for studying organic reactions and mechanisms, particularly those involving indole chemistry.
**The importance of BID stems from its unique structural characteristics:**
* **Two indole rings:** These rings provide a platform for incorporating various functional groups and modifying the molecule's properties.
* **Diaza-butadiene moiety:** This part of the molecule introduces a conjugated system, which is crucial for the compound's electronic and optical properties.
Overall, BID is a versatile and valuable compound that plays a significant role in various research fields. Its importance lies in its ability to serve as a building block for complex organic molecules, a model system for studying indole derivatives, and a potential source for novel materials and drugs.
1,4-bis(3-indolyl)-2,3-diaza-1,3-butadiene: a fluoride probe; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 14692 |
CHEMBL ID | 1906165 |
SCHEMBL ID | 3349880 |
MeSH ID | M0539737 |
Synonym |
---|
smr001821456 |
AKOS024332277 |
FT-0633504 |
SCHEMBL3349880 |
CHEMBL1906165 |
indole-3-carboxaldehyde azine |
DTXSID50924444 |
3,3'-(hydrazinediylidenedimethanylylidene)di(1h-indole) |
1,4-bis(3-indolyl)-2,3-diaza-1,3-butadiene |
1-(1h-indol-3-yl)-n-(1h-indol-3-ylmethylideneamino)methanimine |
1,2-pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (s) |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
TDP1 protein | Homo sapiens (human) | Potency | 4.6109 | 0.0008 | 11.3822 | 44.6684 | AID686978 |
Smad3 | Homo sapiens (human) | Potency | 28.1838 | 0.0052 | 7.8098 | 29.0929 | AID588855 |
PINK1 | Homo sapiens (human) | Potency | 39.8107 | 2.8184 | 18.8959 | 44.6684 | AID624263 |
Parkin | Homo sapiens (human) | Potency | 39.8107 | 0.8199 | 14.8306 | 44.6684 | AID624263 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (40.00) | 29.6817 |
2010's | 2 (40.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.56) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |