Compounds > 1,4,6,8-tetramethyl-2h-furo(2,3-h)quinolin-2-one
Page last updated: 2024-11-12

1,4,6,8-tetramethyl-2h-furo(2,3-h)quinolin-2-one

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,4,6,8-tetramethyl-2H-furo(2,3-h)quinolin-2-one: a tetramethylfuroquinolinone; an isoster of angelicin; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10466871
CHEMBL ID24556
SCHEMBL ID6140019
MeSH IDM0267109

Synonyms (8)

Synonym
174022-38-9
1,4,6,8-tetramethyl-2h-furo(2,3-h)quinolin-2-one
CHEMBL24556
SCHEMBL6140019
1,4,6,8-tetramethylfuro[2,3-h]quinolin-2(1h)-one
1,4,6,8-tetramethyl-2h-furo[2,3-h]quinolin-2-one
DTXSID20877776
1,4,6,8-tetramethylfuro[2,3-h]quinolin-2-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID66155Compound was tested for the inhibition of DNA synthesis in Ehrlich cells by incubation in the dark.1996Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
Angular furoquinolinones, psoralen analogs: novel antiproliferative agents for skin diseases. Synthesis, biological activity, mechanism of action, and computer-aided studies.
AID16673Association constant of binding of compound with calf thymus DNA was determined by using equilibrium dialysis.1996Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
Angular furoquinolinones, psoralen analogs: novel antiproliferative agents for skin diseases. Synthesis, biological activity, mechanism of action, and computer-aided studies.
AID21302Solubility of compound in water1996Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
Angular furoquinolinones, psoralen analogs: novel antiproliferative agents for skin diseases. Synthesis, biological activity, mechanism of action, and computer-aided studies.
AID66159Compound was tested for the inhibition of DNA synthesis in Ehrlich cells by incubation in the dark relative to furoquinolinone1996Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
Angular furoquinolinones, psoralen analogs: novel antiproliferative agents for skin diseases. Synthesis, biological activity, mechanism of action, and computer-aided studies.
AID66161Compound was tested for the inhibition of RNA synthesis in Ehrlich cells by incubation in the dark relative to furoquinolinone1996Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
Angular furoquinolinones, psoralen analogs: novel antiproliferative agents for skin diseases. Synthesis, biological activity, mechanism of action, and computer-aided studies.
AID66156Compound was tested for the inhibition of RNA synthesis in Ehrlich cells by incubation in the dark.1996Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
Angular furoquinolinones, psoralen analogs: novel antiproliferative agents for skin diseases. Synthesis, biological activity, mechanism of action, and computer-aided studies.
AID66153Compound was tested for the inhibition of RNA synthesis in Ehrlich cells by UV -A Irradiation1996Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
Angular furoquinolinones, psoralen analogs: novel antiproliferative agents for skin diseases. Synthesis, biological activity, mechanism of action, and computer-aided studies.
AID66152Compound was tested for the inhibition of DNA synthesis in Ehrlich cells by UV -A Irradiation1996Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
Angular furoquinolinones, psoralen analogs: novel antiproliferative agents for skin diseases. Synthesis, biological activity, mechanism of action, and computer-aided studies.
AID66160Compound was tested for the inhibition of RNA synthesis in Ehrlich cells by UV -A Irradiation relative to furoquinolinone1996Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
Angular furoquinolinones, psoralen analogs: novel antiproliferative agents for skin diseases. Synthesis, biological activity, mechanism of action, and computer-aided studies.
AID21075Partition Coefficient in n-octanol / water medium1996Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
Angular furoquinolinones, psoralen analogs: novel antiproliferative agents for skin diseases. Synthesis, biological activity, mechanism of action, and computer-aided studies.
AID66158Compound was tested for the inhibition of DNA synthesis in Ehrlich cells by UV -A Irradiation relative to furoquinolinone1996Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
Angular furoquinolinones, psoralen analogs: novel antiproliferative agents for skin diseases. Synthesis, biological activity, mechanism of action, and computer-aided studies.
AID208392Surviving fraction was evaluated at concentration 2 uM in T2 phage1996Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
Angular furoquinolinones, psoralen analogs: novel antiproliferative agents for skin diseases. Synthesis, biological activity, mechanism of action, and computer-aided studies.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.25 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.20 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methoxsalen
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.. methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.		2.6830aromatic ether;
psoralens		antineoplastic agent;
cross-linking reagent;
dermatologic drug;
photosensitizing agent;
plant metabolite
carbostyril
Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.		2.9240monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
angelicin
angelicin: used as tranquillizer; sedative; or anticonvulsant; structure		1.9910furanocoumarin
ConditionIndicatedRelationship StrengthStudiesTrials
Dermatoses
[description not available]		01.9910
Skin Diseases
Diseases involving the DERMIS or EPIDERMIS.		01.9910
Carcinoma, Ehrlich Tumor
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.		02.4120