Page last updated: 2024-12-08

1-4-(3-methyltriazeno)benzoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-4-(3-methyltriazeno)benzoic acid is a chemical compound with the formula **C8H9N3O2**. It is also known as **MTB** or **3-methyl-1-(4-carboxyphenyl)triazene**.

**Why is it important for research?**

MTB has been investigated for its potential as an **anticancer agent**. Its mechanism of action involves the release of a **cytotoxic methylating agent** within tumor cells. This methylation process can disrupt crucial cellular processes, leading to cell death.

Here's a breakdown of its importance:

* **Anti-tumor activity:** MTB has shown promising activity against various cancer cell lines, including those derived from leukemia, lymphoma, and breast cancer.
* **Mechanism of action:** Understanding how MTB works provides valuable insights for developing new and more effective cancer therapies.
* **Potential drug development:** MTB itself may serve as a lead compound for the development of new anticancer drugs, either through modifications to its structure or by using it as a template to design new agents.

However, it's crucial to note that:

* **MTB is not currently approved for clinical use.**
* **Research is ongoing to assess its safety and efficacy in humans.**
* **Further research is needed to determine its therapeutic potential and optimize its use.**

Therefore, while MTB shows promise as a potential anticancer agent, more research is needed to understand its full potential and to develop safe and effective treatment strategies.

1-4-(3-methyltriazeno)benzoic acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID154190
SCHEMBL ID22692231
MeSH IDM0152217

Synonyms (9)

Synonym
mtba
40843-84-3
1-4-(3-methyltriazeno)benzoic acid
1-p-(3-methyltriazeno)benzoic acid potassium salt
mm-cook
4-(3-methyl-1-triazenyl)benzoic acid
benzoic acid, 4-(3-methyl-1-triazenyl)-
DTXSID20193822
SCHEMBL22692231
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (33.33)18.7374
1990's7 (58.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.80 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.58 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (7.14%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (92.86%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]