| ID Source | ID |
|---|---|
| PubMed CID | 700979 |
| CHEMBL ID | 1536809 |
| CHEBI ID | 121099 |
| Synonym |
|---|
| IFLAB1_001551 |
| smr000060512 |
| MLS000098769 , |
| CHEBI:121099 |
| HMS1416G11 |
| AKOS001010375 |
| 1,3-diphenylpyrazole-4-carbonitrile |
| HMS2472O04 |
| 1,3-diphenyl-1h-pyrazole-4-carbonitrile |
| 1h-pyrazole-4-carbonitrile, 1,3-diphenyl- |
| 17647-21-1 |
| cid_700979 |
| 1,3-diphenyl-4-pyrazolecarbonitrile |
| bdbm49022 |
| CHEMBL1536809 |
| Q27209342 |
| DTXSID70351470 |
| Z56813172 |
| Class | Description |
|---|---|
| ring assembly | Two or more cyclic systems (single rings or fused systems) which are directly joined to each other by double or single bonds are named ring assemblies when the number of such direct ring junctions is one less than the number of cyclic systems involved. |
| pyrazoles | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 8.4921 | 0.0072 | 15.7588 | 89.3584 | AID588342 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 0.3162 | 0.0184 | 6.8060 | 14.1254 | AID624417 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 20.5962 | 0.0041 | 10.8903 | 31.5287 | AID504467 |
| TDP1 protein | Homo sapiens (human) | Potency | 8.9125 | 0.0008 | 11.3822 | 44.6684 | AID686978 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 5.0119 | 0.0013 | 18.0743 | 39.8107 | AID926; AID938 |
| 67.9K protein | Vaccinia virus | Potency | 20.3865 | 0.0001 | 8.4406 | 100.0000 | AID720579; AID720580 |
| geminin | Homo sapiens (human) | Potency | 0.0651 | 0.0046 | 11.3741 | 33.4983 | AID624297 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 0.0041 | 9.9625 | 28.1838 | AID2675 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Substance | Description | Relationhip Strength | Studies | Trials | Classes | Roles |
|---|---|---|---|---|---|---|
| my 5445 | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| famprofazone | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| nafoxidine | [no description available] | low | 0 | 0 | benzenes; naphthalenes; ring assembly | |
| nifenazone | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-phenyl-4-pyrazolo[3,4-d]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| ramifenazone | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-[6-amino-3-(4-methoxyphenyl)-1-pyridazin-1-iumyl]butanoic acid | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| oxolamine | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| imolamine | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| difenzoquat | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| irinotecan | [no description available] | low | 0 | 0 | carbamate ester; delta-lactone; N-acylpiperidine; pyranoindolizinoquinoline; ring assembly; tertiary alcohol; tertiary amino compound | antineoplastic agent; apoptosis inducer; EC 5.99.1.2 (DNA topoisomerase) inhibitor; prodrug |
| n-demethylantipyrine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-Formyl-antipyrine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-amino-1-phenyl-1H-pyrazole-4-carbonitrile | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| benzpiperylone | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-hydroxyantipyrine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| galgravin | [no description available] | low | 0 | 0 | aryltetrahydrofuran; dimethoxybenzene; lignan; ring assembly | bone density conservation agent; neuroprotective agent; plant metabolite; platelet aggregation inhibitor |
| cl 218872 | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 3-phenyl-1H-pyrazole-5-carboxylic acid | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(2-hydroxy-4-(1,1-dimethylheptylphenyl)cyclohexan-1-ol) | [no description available] | low | 0 | 0 | alkylbenzene; ring assembly | |
| kolaviron | [no description available] | low | 0 | 0 | 4'-methoxyflavanones; biflavonoid; dihydroflavonols; ring assembly; secondary alpha-hydroxy ketone | hepatoprotective agent; plant metabolite |
| cgs 20625 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 3 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-tert-butyl-6-ethyl-1-phenyl-4-pyrazolo[3,4-d]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| diospyrin | [no description available] | low | 0 | 0 | hydroxy-1,4-naphthoquinone; ring assembly | |
| 4-methyl-7-phenyl-3-pyrazolo[5,1-c][1,2,4]triazinecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-amino-2,6-dimethyl-5-[3-(4-methylphenyl)-1H-pyrazol-5-yl]-3-pyridazinone | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-phenyl-4-pyrazolol | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4,5-diphenyl-1,2,3-triazole | [no description available] | low | 0 | 0 | benzenes; ring assembly; triazoles | |
| 7-amino-2-methyl-3-phenyl-6-pyrazolo[1,5-a]pyrimidinecarbonitrile | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-(4-hydroxy-3,5-dimethylphenyl)-2-methylphthalazin-1(2H)-one | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| N,N-dimethyl-6-phenyl-3-pyridazinamine | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 6-amino-4-(2,3-dimethoxyphenyl)-3-methyl-1-phenyl-4H-pyrano[2,3-c]pyrazole-5-carbonitrile | [no description available] | low | 0 | 0 | pyranopyrazole; ring assembly | |
| 5-(2-ethoxyphenyl)-3-(2-methoxy-6-methyl-3-pyridinyl)-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 4-[2-(3-fluorophenyl)-5-methyl-7-pyrazolo[1,5-a]pyrimidinyl]morpholine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-(4-chlorophenyl)-4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinecarboxamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 2-[[6-(3,4-dimethoxyphenyl)-3-pyridazinyl]thio]-1-(1-pyrrolidinyl)ethanone | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 4-[2-(3-fluorophenyl)-5,6,7,8-tetrahydropyrazolo[5,1-b]quinazolin-9-yl]morpholine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 6-amino-4-(2,5-dimethoxyphenyl)-3-methyl-1-(4-methylphenyl)-4H-pyrano[2,3-c]pyrazole-5-carbonitrile | [no description available] | low | 0 | 0 | pyranopyrazole; ring assembly | |
| 2-[[2-(4-methoxyphenyl)-5-methyl-7-pyrazolo[1,5-a]pyrimidinyl]amino]ethanol | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-[3-(4-fluorophenyl)-2,5,6-trimethyl-7-pyrazolo[1,5-a]pyrimidinyl]morpholine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-[2-[[2-[[1-(4-methoxyphenyl)-4-pyrazolo[3,4-d]pyrimidinyl]thio]-1-oxoethyl]amino]-4-thiazolyl]acetic acid ethyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| LSM-34623 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-[[6-(3,4-dimethoxyphenyl)-3-pyridazinyl]thio]-1-(4-morpholinyl)ethanone | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 2-[[1-(4-methylphenyl)-4-pyrazolo[3,4-d]pyrimidinyl]thio]acetic acid ethyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-[(3-oxo-5-phenyl-1,2-dihydropyrazol-4-yl)-(3-thiophenyl)methyl]propanedinitrile | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[2-(1-cyclohexenyl)ethyl]-1-phenyl-4-pyrazolo[3,4-d]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-[(3-ethoxycarbonyl-4-thiophen-2-yl-2-thiophenyl)amino]-5-oxopentanoic acid | [no description available] | low | 0 | 0 | ring assembly; thiophenes | |
| N-(2-oxolanylmethyl)-1-phenyl-4-pyrazolo[3,4-d]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-phenyl-N-(3-propan-2-yloxypropyl)-4-pyrazolo[3,4-d]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-[2-[[1-(4-chlorophenyl)-4-pyrazolo[3,4-d]pyrimidinyl]amino]ethoxy]ethanol | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-(4-chlorophenyl)-N-(1-methoxypropan-2-yl)-4-pyrazolo[3,4-d]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-[1-(4-methoxyphenyl)-4-pyrazolo[3,4-d]pyrimidinyl]-4-piperidinecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-[2-[(1-phenyl-4-pyrazolo[3,4-d]pyrimidinyl)amino]ethoxy]ethanol | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| LSM-17424 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| LSM-19719 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-[2-oxo-2-[4-(4-phenyl-1-phthalazinyl)-1-piperazinyl]ethyl]isoindole-1,3-dione | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| LSM-28231 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2,6-dimethyl-4-(1-phenyl-4-pyrazolyl)furo[2,3-d]pyrimidine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-phenyl-1H-cinnolin-4-one | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| N-tert-butyl-2-[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]benzamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| Glyceryl lactopalmitate | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-[3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-N-(3-pyridinyl)propanamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 3-[3-(4-tert-butylphenyl)-1,2,4-oxadiazol-5-yl]-N-methylpropanamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-N-(3-methylphenyl)propanamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 3-[3-(4-tert-butylphenyl)-1,2,4-oxadiazol-5-yl]-N-ethylpropanamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 2-[(2,5-dimethyl-3-phenyl-7-pyrazolo[1,5-a]pyrimidinyl)thio]acetonitrile | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| [2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]phenyl]-(1-pyrrolidinyl)methanone | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 7-(3,5-dimethyl-1-pyrazolyl)-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-(3,5-dimethoxyphenyl)-3-(2-methoxyphenyl)-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 6-amino-1-(4-fluorophenyl)-3-methyl-4-thiophen-2-yl-5-pyrazolo[3,4-b]pyridinecarbonitrile | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-(3,4-dimethoxyphenyl)-3-methyl-1H-pyrazol-5-amine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-(4-bromophenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-(4-bromophenyl)-4-methyl-1H-pyrazol-5-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-(3-methylphenyl)-N-(2-pyridinylmethyl)-4-pyrazolo[3,4-d]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-tert-butyl-1-phenyl-4-pyrazolo[3,4-d]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-(4-cyclohexylphenyl)-1,2-dihydropyrazol-3-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-[(dimethylamino)methyl]-4-methyl-6-(1-methylcyclohexyl)phenol | [no description available] | low | 0 | 0 | alkylbenzene; ring assembly | |
| 2-(3-oxo-2-phenyl-1H-pyrazol-5-yl)acetic acid methyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-hydroxy-1-(4-methylphenyl)-3-pyrazolecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-(4-fluorophenyl)-4-hydroxy-3-pyrazolecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-(3,5-dimethyl-1-pyrazolyl)-6-methyl-1-phenylpyrazolo[3,4-d]pyrimidine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5,7-dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-(methoxymethyl)-2-phenyl-1H-pyrazolo[1,5-a]pyrimidin-7-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(4-chlorophenyl)-2,5-dimethyl-1H-pyrazolo[1,5-a]pyrimidin-7-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-(5,7-dimethyl-3-phenyl-6-pyrazolo[1,5-a]pyrimidinyl)acetic acid ethyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5,7-dimethyl-2-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| (3-methyl-1-phenyl-5-thieno[2,3-c]pyrazolyl)-(3-methyl-1-pyrazolyl)methanone | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(4-ethoxyphenyl)-1H-pyrazole-5-carbohydrazide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-chloro-6-phenyl-[1,2,4]triazolo[4,3-b]pyridazine | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 3-[2-(4-fluorophenyl)-5-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidin-6-yl]propanoic acid ethyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-phenyl-5,6,7,8-tetrahydro-1H-pyrazolo[5,1-b]quinazolin-9-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-(3-chloro-4-methylphenyl)-3-pyridin-4-yl-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 7,8-dimethoxy-5-methyl-3-phenylpyrazolo[3,4-c]isoquinoline | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 7,8-dimethoxy-1,5-dimethyl-3-phenylpyrazolo[3,4-c]isoquinoline | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-[(4-chlorophenyl)thio]-5-methyl-2-phenyl-1H-pyrazol-3-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-methyl-1-phenyl-4-pyrazolecarboxylic acid (4-methoxyphenyl) ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-(4-methylphenyl)-2-phenyl-3-pyrazolamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-(4-fluorophenyl)-1-(3-methylphenyl)-4-pyrazolo[3,4-d]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-methoxy-2-[3-(4-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl]phenol | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-(3,5-dimethoxyphenyl)-3-phenyl-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 3-(4-methoxyphenyl)-5-(4-methylphenyl)-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 3-(4-methoxyphenyl)-5-(2-phenylethyl)-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 4-(2,4-dimethylphenyl)-2H-phthalazin-1-one | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 5-amino-3-ethyl-1-phenyl-4-pyrazolecarbonitrile | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-[(4-methylphenoxy)methyl]-3-phenyl-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 3-(2-methoxy-6-methyl-3-pyridinyl)-5-(2-methoxyphenyl)-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 1-(4-methylphenyl)sulfonyl-4-phenyl-3-pyrazolamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| LSM-16463 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-cyclopropyl-3-methyl-1-phenyl-5-thieno[2,3-c]pyrazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-(3,4-diethoxyphenyl)-3-pyridin-4-yl-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 7-amino-2-(4-tert-butylphenyl)-6-pyrazolo[1,5-a]pyrimidinecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-(5-bromo-2-chlorophenyl)-3-pyridin-4-yl-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 2-(4-ethoxyphenyl)-3,4-dimethyl-7-[2-(1-pyrrolidinyl)ethylthio]pyrazolo[3,4-d]pyridazine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 8-[1-(3-methylphenyl)-4-pyrazolo[3,4-d]pyrimidinyl]-1,4-dioxa-8-azaspiro[4.5]decane | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(4-chlorophenyl)-5-propyl-1H-pyrazolo[1,5-a]pyrimidin-7-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2,5-dimethyl-3-phenyl-7-pyrazolo[1,5-a]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-methyl-N'-(1-oxo-2-phenoxyethyl)-1-phenyl-5-thieno[2,3-c]pyrazolecarbohydrazide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-[(3,5-dichloro-2-hydroxyphenyl)methylamino]-1,5-dimethyl-2-phenyl-3-pyrazolone | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-(3-bromophenyl)-2-(4-bromophenyl)-7-methylpyrazolo[3,4-d]pyridazine | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 4-(3-bromophenyl)-7-methyl-2-(4-methylphenyl)pyrazolo[3,4-d]pyridazine | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 1-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-3-(4-methylphenyl)sulfonylurea | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-2-thiophenecarboxamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-2-(2,3,5-trimethylphenoxy)acetamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 2-(4-hydroxyphenyl)-5-methyl-1H-pyrazol-3-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[[3-(4-fluorophenyl)-1-phenyl-4-pyrazolyl]methyl]-1-phenylmethanamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-phenyl-5-[[[4-phenyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]thio]methyl]-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 2,5-dichloro-N-methyl-N-[[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]benzenesulfonamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 4-(5-amino-4-phenyl-1-pyrazolyl)benzoic acid | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(4-bromophenyl)-5-(3,5-dimethoxyphenyl)-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 2-[4-[[4-(4-methoxyphenyl)-1-phthalazinyl]amino]phenyl]acetamide | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| N-(3,4-dimethoxyphenyl)-1-(3-methylphenyl)-4-pyrazolo[3,4-d]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| LSM-28273 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N'-[2-[[1-(4-methylphenyl)-4-pyrazolo[3,4-d]pyrimidinyl]thio]-1-oxoethyl]-2-furancarbohydrazide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-morpholinyl-[4-[3-[4-(4-morpholinylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-piperidinyl]methanone | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 2-[(4-chlorophenyl)methyl]-6-phenyl-5-(1-piperidinyl)-3-pyridazinone | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 2-[(3-chlorophenyl)methyl]-6-phenyl-5-(1-piperidinyl)-3-pyridazinone | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 6-phenyl-5-(1-piperidinyl)-2-prop-2-enyl-3-pyridazinone | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 5-(6-chloro-3-pyridinyl)-3-(3-methoxyphenyl)-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 1-methyl-5-[(4-methylphenyl)thio]-3-phenyl-4-pyrazolecarbonitrile | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-phenyl-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-(2,5-dimethoxyphenyl)-3-[3-(4-methoxyphenyl)-1H-pyrazol-5-yl]-1H-1,2,4-triazole-5-thione | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-tert-butyl-3-(4-chlorophenyl)-N-(2-pyridinylmethyl)-7-pyrazolo[1,5-a]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[2-methoxy-5-(3-methyl-4-oxo-1-phthalazinyl)phenyl]-2-(4-methylphenoxy)acetamide | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| LSM-20639 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 6-[[(4-chlorophenyl)thio]methyl]-2-phenyl-1,7-dihydropyrazolo[3,4-b]pyridine-3,4-dione | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-(3,4-dichlorophenyl)-2-[4-(4-methoxyphenyl)-1-oxo-2-phthalazinyl]acetamide | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 4-(2,5-dimethoxyphenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-1H-1,2,4-triazole-5-thione | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[5-methyl-2-(4-methylphenyl)-3-pyrazolyl]-2-[(7-methyl-4-oxo-2,3-dihydro-1H-cyclopenta[c][1]benzopyran-9-yl)oxy]acetamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-tert-butyl-2-methyl-3-phenyl-N-(2-pyridinylmethyl)-7-pyrazolo[1,5-a]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-(4-methoxyphenyl)-N-[2-(4-morpholinyl)ethyl]-4-pyrazolo[3,4-d]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-(5-tert-butyl-2-phenyl-3-pyrazolyl)-2-[(6-methyl-1H-benzimidazol-2-yl)thio]acetamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-3-(2-methylphenoxy)propanamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-(1,3-benzodioxol-5-ylmethyl)-2-[(3-methyl-4-oxo-5-thiophen-2-yl-2-thieno[2,3-d]pyrimidinyl)thio]acetamide | [no description available] | low | 0 | 0 | ring assembly; thiophenes | |
| N-[4-(4-methyl-2-thiazolyl)-2-phenyl-3-pyrazolyl]-3-(trifluoromethyl)benzamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-(4-fluorophenyl)-3-methyl-5-thieno[2,3-c]pyrazolecarboxylic acid [2-(methylamino)-2-oxoethyl] ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-chloro-N-[3-(4-methylphenyl)-1-phenyl-4-pyrazolyl]acetamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(4-methoxyphenyl)-1-phenyl-4-pyrazolamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2,5-diphenyl-3-pyrazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-chloro-N-(2-phenyl-5-propyl-3-pyrazolyl)acetamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-[[1-oxo-2-(1H-1,2,4-triazol-5-ylthio)ethyl]amino]-4-thiophen-2-yl-3-thiophenecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | ring assembly; thiophenes | |
| 3-(2-chlorophenyl)-N-cyclohexyl-5-methyl-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-4-isoxazolecarboxamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| N-(5-methyl-2-phenyl-3-pyrazolyl)-2-phenoxyacetamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-phenyl-N-(3-pyridinylmethyl)-3-thiophen-2-yl-4-pyrazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[[2-(diethylamino)ethylamino]-sulfanylidenemethyl]-3-(4-methoxyphenyl)-1-phenyl-4-pyrazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(4-methoxyphenyl)-N-[[[oxo(pyridin-4-yl)methyl]hydrazo]-sulfanylidenemethyl]-1-phenyl-4-pyrazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-methyl-N,1-diphenyl-4-pyrazolecarbothioamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-(2-chlorophenyl)-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-3-methyl-5-thieno[2,3-c]pyrazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-(3,5-dimethyl-1-pyrazolyl)benzamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-[2-[(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)amino]-2-oxoethyl]-4-oxo-1-phthalazinecarboxylic acid | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-(4-propylphenyl)-1H-pyrazol-3-amine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-2-[(6-methyl-1H-benzimidazol-2-yl)thio]acetamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-methyl-1-phenyl-5-thieno[2,3-c]pyrazolecarboxylic acid [2-(butylamino)-2-oxoethyl] ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N2-[5-(4-chlorophenyl)-2-phenyl-3-pyrazolyl]benzene-1,2-diamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N2-[2-(4-methylphenyl)-5-phenyl-3-pyrazolyl]benzene-1,2-diamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N2-(5-phenyl-1H-pyrazol-3-yl)benzene-1,2-diamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-phenyl-5-thiophen-2-yl-3-pyrazolecarboxylic acid [2-(3-nitroanilino)-2-oxoethyl] ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-phenyl-5-thiophen-2-yl-3-pyrazolecarboxylic acid [2-(2-chloro-5-nitroanilino)-2-oxoethyl] ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-phenyl-5-thiophen-2-yl-3-pyrazolecarboxylic acid [2-(4-chloro-3-nitroanilino)-2-oxoethyl] ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[[(4-oxo-1-phenyl-5-pyrazolo[3,4-d]pyrimidinyl)amino]-sulfanylidenemethyl]benzamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N2-[5-(3-chlorophenyl)-2-phenyl-3-pyrazolyl]benzene-1,2-diamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-phenyl-5-sulfanylidene-3,7,8,9,10,11-hexahydropyrazolo[4,5]pyrimido[3,5-a]azepin-1-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(3,4-dimethylphenyl)-1-(phenylmethyl)-4-pyrazolecarboxaldehyde | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-(3-methyl-1-phenyl-1H-pyrazolo[3,4-b]quinolin-4-yl)morpholine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N,N-diethyl-5-thiophen-2-yl-2-thiophenecarboxamide | [no description available] | low | 0 | 0 | ring assembly; thiophenes | |
| 2,5-bis(3,5-dimethyl-1-phenyl-4-pyrazolyl)-1,3,4-oxadiazole | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-(3-methylphenyl)-2-(3-nitrophenyl)-3-pyrazolamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-(4-methylphenyl)-2-(3-nitrophenyl)-3-pyrazolamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(2,4-dichlorophenyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-(3,5-dimethyl-1-pyrazolyl)benzonitrile | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| sc 514 | [no description available] | low | 0 | 0 | ring assembly; thiophenes | |
| 5-(2,3-dihydrobenzofuran-5-yl)-3-(4-fluorophenyl)-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 1-(4-fluorophenyl)-3-[4-(4-fluorophenyl)-2-methyl-5-(trifluoromethyl)-3-pyrazolyl]urea | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3,3-dimethyl-5-oxo-5-[(3-phenyl-1H-pyrazol-5-yl)amino]pentanoic acid | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-[(4-chlorophenyl)-oxomethyl]-5-hydroxy-5-phenyl-4H-pyrazole-3-carboxylic acid methyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 6-amino-4-(2-methylpropyl)-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | [no description available] | low | 0 | 0 | pyranopyrazole; ring assembly | |
| 1,3,8-trimethyl-5,10-diphenylpyrimido[1,2]pyrrolo[4,5-b]pyridazine-2,4-dione | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 5-[[(1-cyclohexyl-5-tetrazolyl)thio]methyl]-3-phenyl-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 4-(5-methyl-3-oxo-1H-pyrazol-2-yl)benzoic acid | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-[1-(4-chlorophenyl)-4-pyrazolo[3,4-d]pyrimidinyl]-2,6-dimethylmorpholine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-(4-methoxyphenyl)-N,N-dipropyl-4-pyrazolo[3,4-d]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-3-hydroxy-3-phenyl-1-isoindolone | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-(1,3-diphenyl-4-pyrazolyl)-3-(2-furanylmethyl)-4-thiazolidinone | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(4-fluorophenyl)-N-[3-(1-imidazolyl)propyl]-1-phenyl-4-pyrazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-(4-fluorophenyl)-3-methyl-5-thieno[2,3-c]pyrazolecarboxylic acid (2-oxo-3-oxolanyl) ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3,5-dimethyl-1-phenyl-4-pyrazolecarboxylic acid [2-[4-amino-1-methyl-3-(2-methylpropyl)-2,6-dioxo-5-pyrimidinyl]-2-oxoethyl] ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-methyl-3-phenyl-1H-pyrazole-5-carbohydrazide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(4-fluorophenyl)-5-(2-furanyl)-2-phenyl-3,4-dihydropyrazole | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 6-amino-4-(3-furanyl)-3-(4-methoxyphenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | [no description available] | low | 0 | 0 | pyranopyrazole; ring assembly | |
| 1-[3-[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-1-butanone | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 7-(2-ethyl-1-piperidinyl)-5-methyl-2-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-(2,4-dimethoxyphenyl)-2-[1-(3,4-dimethylphenyl)-4-oxo-5-pyrazolo[3,4-d]pyrimidinyl]acetamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-[3-(4-methylphenyl)-6-oxo-1-pyridazinyl]-N-[2-(2-methyl-1-piperidinyl)ethyl]propanamide | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| N-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-1,3-benzodioxole-5-carboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-(2-methoxyphenyl)-N-[4-[5-(3-methoxyphenyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 4-morpholinecarboxylic acid [4-[6-amino-5-cyano-3-(4-methylphenyl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]phenyl] ester | [no description available] | low | 0 | 0 | pyranopyrazole; ring assembly | |
| N-(3-chlorophenyl)-2-[1-(3,4-dimethylphenyl)-4-oxo-5-pyrazolo[3,4-d]pyrimidinyl]acetamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-(4-chlorophenyl)-5-[1-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-piperidinyl]-4-pyrazolecarboxylic acid | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[2-(2,3-dimethylphenyl)-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-methoxybenzamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 3-(4-bromophenyl)-1H-pyrazole-5-carboxylic acid methyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-methyl-N-(5-methyl-2-phenyl-3-pyrazolyl)-3-isoxazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-(4-ethoxyphenyl)-5-[1-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-piperidinyl]-6-pyrazolo[1,5-a]pyrimidinecarboxylic acid | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-[5-amino-3-(4-chlorophenyl)-1-pyrazolyl]propanoic acid ethyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-(4-methoxyphenyl)-N-[4-[5-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| N-(5-chloro-2,4-dimethoxyphenyl)-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| N-ethyl-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(phenylmethyl)propanamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| N-[2-(dimethylamino)ethyl]-2-[3-(4-methylphenyl)-6-oxo-1-pyridazinyl]acetamide | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 3-methyl-N-[2-(4-morpholinyl)ethyl]-1-phenyl-5-thieno[2,3-c]pyrazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)propanamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| N-ethyl-N-(2-ethylphenyl)-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 6-amino-4-methyl-3-(4-methylphenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | [no description available] | low | 0 | 0 | pyranopyrazole; ring assembly | |
| 1,3-diphenyl-4-pyrazolecarboxylic acid [2-[(3,5-dichloro-2-pyridinyl)amino]-2-oxoethyl] ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-[3-(1,3-diphenyl-4-pyrazolyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-4-oxobutanoic acid | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| gtp 14564 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-amino-7,7-dimethyl-5-oxo-4-[1-phenyl-3-(4-propan-2-ylphenyl)-4-pyrazolyl]-6,8-dihydro-4H-1-benzopyran-3-carbonitrile | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[4-[5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl]phenyl]-2-(4-methoxyphenyl)acetamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 5-[3-[3-(4-methoxyphenyl)-1-phenyl-4-pyrazolyl]-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-5-oxopentanoic acid | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-[1-(4-bromophenyl)-2-nitroethyl]-5-methyl-2-phenyl-1H-pyrazol-3-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-ethyl-2-sulfanylidene-5-thiophen-2-yl-1H-thieno[2,3-d]pyrimidin-4-one | [no description available] | low | 0 | 0 | ring assembly; thiophenes | |
| 5-chloro-4-[methoxy(phenyl)methyl]-1-methyl-3-phenylpyrazole | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 6-amino-3-(3-methoxyphenyl)-4-(3-thiophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | [no description available] | low | 0 | 0 | pyranopyrazole; ring assembly | |
| 5-methyl-3-phenyl-7-(prop-2-enylthio)pyrazolo[1,5-a]pyrimidine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-[4-[3-(4-methoxyphenyl)-1H-pyrazol-5-yl]-1-piperidinyl]-3-nitropyridine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-[(2,6-dichlorophenyl)methyl]-6-phenyl-5-(1-piperidinyl)-3-pyridazinone | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 2-[[1-(4-chlorophenyl)-4-pyrazolo[3,4-d]pyrimidinyl]amino]-1-butanol | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-[(2-hydroxy-3-nitrophenyl)-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methyl]-5-methyl-2-phenyl-1H-pyrazol-3-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-butan-2-yl-2-[[3-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-4-oxo-2-quinazolinyl]thio]acetamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(5-bromo-2-furanyl)-5-(4-methoxyphenyl)-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| sew2871 | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 7-(1-azepanyl)-3-(2-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-methyl-4-[(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-(3-nitrophenyl)methyl]-2-phenyl-1H-pyrazol-3-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-(3,5-dimethyl-1-pyrazolyl)benzoic acid [2-(4-chloro-2-nitroanilino)-2-oxoethyl] ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| am 281 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| LSM-28389 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| LSM-16826 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-(4-methoxyphenyl)-N-(2-oxolanylmethyl)-4-pyrazolo[3,4-d]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | [no description available] | low | 0 | 0 | alkylbenzene; ring assembly | |
| 4-[1-(4-fluorophenyl)-2-nitroethyl]-5-methyl-2-phenyl-1H-pyrazol-3-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 6-amino-4-(3,5-dimethyl-1-phenyl-4-pyrazolyl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | [no description available] | low | 0 | 0 | pyranopyrazole; ring assembly | |
| 3-(4-ethoxyphenyl)-N-[(1-methyl-4-piperidinylidene)amino]-1H-pyrazole-5-carboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 6-[5-chloro-3-methyl-1-(4-methylphenyl)-4-pyrazolyl]-3,4-dimethyl-2-oxo-1,6-dihydropyrimidine-5-carboxylic acid ethyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[3-(1-imidazolyl)propyl]-2-methyl-3-phenyl-5-propyl-7-pyrazolo[1,5-a]pyrimidinamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-tert-butyl-3-(4-chlorophenyl)-7-(2-ethyl-1-imidazolyl)pyrazolo[1,5-a]pyrimidine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazole-5-carboxylic acid ethyl ester | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 4-[1-(2,4-dichlorophenyl)-2-nitroethyl]-5-(2-hydroxyphenyl)-1,2-dihydropyrazol-3-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| [5-(4-chlorophenyl)-1-(3,4-dichlorophenyl)-3-pyrazolyl]-(4-morpholinyl)methanone | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-[3-(2-chloro-1-oxoethyl)-2,5-dimethyl-1-pyrrolyl]-1,5-dimethyl-2-phenyl-3-pyrazolone | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 6-amino-1,3-diphenyl-4-(3,4,5-trimethoxyphenyl)-4H-pyrano[2,3-c]pyrazole-5-carbonitrile | [no description available] | low | 0 | 0 | pyranopyrazole; ring assembly | |
| ginkgetin | [no description available] | low | 0 | 0 | biflavonoid; hydroxyflavone; methoxyflavone; ring assembly | anti-HSV-1 agent; antineoplastic agent; cyclooxygenase 2 inhibitor; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; metabolite |
| amentoflavone | [no description available] | low | 0 | 0 | biflavonoid; hydroxyflavone; ring assembly | angiogenesis inhibitor; antiviral agent; cathepsin B inhibitor; P450 inhibitor; plant metabolite |
| cupressuflavone | [no description available] | low | 0 | 0 | biflavonoid; hydroxyflavone; ring assembly | EC 3.4.21.37 (leukocyte elastase) inhibitor; metabolite; radical scavenger |
| robustaflavone | [no description available] | low | 0 | 0 | biflavonoid; hydroxyflavone; ring assembly | anti-HBV agent; antineoplastic agent; antioxidant; metabolite |
| sciadopitysin | [no description available] | low | 0 | 0 | biflavonoid; hydroxyflavone; methoxyflavone; ring assembly | bone density conservation agent; platelet aggregation inhibitor |
| 2-(4-fluoro-3-methylphenyl)sulfonyl-5-(2-methoxyphenyl)-3-pyrazolamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-[[[3-(2-fluorophenyl)-1-methyl-5-thieno[2,3-c]pyrazolyl]-oxomethyl]amino]-1-piperidinecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(4-chlorophenyl)-N-cyclopropyl-1-methyl-5-thieno[2,3-c]pyrazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(4-chlorophenyl)-1-methyl-N-[(5-methyl-2-furanyl)methyl]-5-thieno[2,3-c]pyrazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-1-(1H-imidazol-5-ylsulfonyl)-3-piperidinecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(4-chlorophenyl)-1-methyl-N-[3-(1-pyrrolidinyl)propyl]-5-thieno[2,3-c]pyrazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-[3-(4-fluorophenyl)-2-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidin-5-yl]-1-piperidinecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-chloro-2-methoxy-N-[[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]-N-propan-2-ylbenzamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| N-(6-acetyl-1,3-benzodioxol-5-yl)-5-methyl-2-phenyl-3-pyrazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(4-chlorophenyl)-N-[2-(diethylamino)ethyl]-1-methyl-5-thieno[2,3-c]pyrazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| vinorelbine | [no description available] | low | 0 | 0 | acetate ester; methyl ester; organic heteropentacyclic compound; organic heterotetracyclic compound; ring assembly; vinca alkaloid | antineoplastic agent; photosensitizing agent |
| HTS 01037 | [no description available] | low | 0 | 0 | ring assembly; thiophenes | |
| 4,5-diphenyl-2,3-dihydro-1H-pyrazolo[3,4-c]pyridazin-3-one | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 1-(3,4-dimethylphenyl)-4-(4-methyl-1-piperidinyl)phthalazine | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 2-(4-nitrophenoxy)-1-[4-(4-phenyl-1-phthalazinyl)-1-piperazinyl]ethanone | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 3-amino-5-(4-bromophenyl)-4-pyridazinecarbonitrile | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| acuminatin | [no description available] | low | 0 | 0 | 1-benzofurans; dimethoxybenzene; neolignan; olefinic compound; ring assembly | fungal metabolite; plant metabolite |
| N,2-dimethyl-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-3-furancarboxamide | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 2-(4-methoxyphenyl)-5-[1-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-piperidinyl]-6-pyrazolo[1,5-a]pyrimidinecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-cyclohexyl-2-[[6-(4-ethoxyphenyl)-3-pyridazinyl]thio]acetamide | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| N-(5-methyl-3-isoxazolyl)-2-[[6-(4-methylphenyl)-3-pyridazinyl]thio]acetamide | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| n-(4-methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetamide | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| N-[4-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]cyclohexanecarboxamide | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 6-(4-ethylphenyl)-3-(methylthio)-[1,2,4]triazolo[4,3-b]pyridazine | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| N-(phenylmethyl)-3-[3,4,6-trimethyl-1-(4-methylphenyl)-5-pyrazolo[3,4-b]pyridinyl]propanamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-(2,1,3-benzothiadiazol-4-ylsulfonyl)-5-(4-chlorophenyl)-3-pyrazolamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| o-demethyltramadol | [no description available] | low | 0 | 0 | alkylbenzene; ring assembly | |
| sr 147778 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| ethiprole | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-(2,4-dichlorophenyl)-6-methyl-N-(1-piperidinyl)-4H-indeno[1,2-c]pyrazole-3-carboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| ws-5995 c | [no description available] | low | 0 | 0 | benzenes; naphthalenes; ring assembly | |
| cc 401 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| ptc 124 | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| fr 180204 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| n-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxamide | [no description available] | low | 0 | 0 | aromatic amide; cyclopropanes; organofluorine compound; pyrazoles; ring assembly | |
| trametinib | [no description available] | low | 0 | 0 | acetamides; aromatic amine; cyclopropanes; organofluorine compound; organoiodine compound; pyridopyrimidine; ring assembly | anticoronaviral agent; antineoplastic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector |
| 2-(2,1,3-benzothiadiazol-4-ylsulfonyl)-5-(4-bromophenyl)-3-pyrazolamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| dactolisib | [no description available] | low | 0 | 0 | imidazoquinoline; nitrile; quinolines; ring assembly; ureas | antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor |
| pyriprole | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-[2-(4-chlorophenyl)-5,7-dimethyl-6-pyrazolo[1,5-a]pyrimidinyl]-N-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]propanamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| macitentan | [no description available] | low | 0 | 0 | aromatic ether; organobromine compound; pyrimidines; ring assembly; sulfamides | antihypertensive agent; endothelin receptor antagonist; orphan drug |
| 3-[2-(3,5-dimethoxyphenyl)-5,7-dimethyl-6-pyrazolo[1,5-a]pyrimidinyl]-N-(phenylmethyl)propanamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| [3-(4-bromophenyl)-1H-pyrazol-5-yl]-[4-(3,4-dimethoxyphenyl)sulfonyl-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-[3-(4-fluorophenyl)-2,5,7-trimethyl-6-pyrazolo[1,5-a]pyrimidinyl]-N-(2-methoxyphenyl)propanamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[[3-(2-chlorophenyl)-1-(4-fluorophenyl)-4-pyrazolyl]methyl]-2-(2-pyridinyl)ethanamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| (3aS,5S,9aS)-5-[1-(2-methoxyphenyl)-4-pyrazolyl]-2-phenyl-3a,4,5,7,8,9-hexahydro-3H-pyrrolo[3,4-h]pyrrolizin-1-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-[[3-(3-fluorophenyl)-1-(4-methoxyphenyl)-4-pyrazolyl]methyl]-4-methoxypiperidine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[[5-(2,4-difluorophenyl)-1H-pyrazol-4-yl]methyl]-1-(3-thiophenyl)-2-propanamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[[3-(3-methylphenyl)-1-(4-methylphenyl)-4-pyrazolyl]methyl]-3-(1-pyrazolyl)-1-propanamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-(1,5-dimethyl-3-pyrazolyl)-N-[[5-(2-fluoro-4-methoxyphenyl)-1H-pyrazol-4-yl]methyl]methanamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| (1R,5S)-6-[[5-(2-fluoro-4-methoxyphenyl)-1H-pyrazol-4-yl]methyl]-6-azabicyclo[3.2.1]octane | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-[[3-(4-fluorophenyl)-1-(4-methylphenyl)-4-pyrazolyl]methyl]-4-[(1-methyl-2-imidazolyl)methyl]piperazine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| (3aS,5S,9aS)-2-[(2-methylphenyl)methyl]-5-(1-methyl-3-phenyl-4-pyrazolyl)-3a,4,5,7,8,9-hexahydro-3H-pyrrolo[3,4-h]pyrrolizin-1-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-ethyl-4-[[methyl-[[3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]methyl]amino]methyl]-2-pyrrolidinone | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 2-(3,5-dimethyl-1-pyrazolyl)-N-[[3-(4-fluorophenyl)-1-(4-methylphenyl)-4-pyrazolyl]methyl]ethanamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-[[3-(2-fluorophenyl)-1-methyl-4-pyrazolyl]methyl]-3-propoxypiperidine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N'-[1-(3,4-dimethylphenyl)-4-pyrazolo[3,4-d]pyrimidinyl]acetohydrazide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 5-(4-chlorophenyl)-2-(4-methoxyphenyl)sulfonyl-3-pyrazolamine | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 1-hydroxy-2-(5-phenyl-1H-pyrazol-3-yl)-4H-1,2,4-benzotriazin-3-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 2-[[6-(4-ethylphenyl)-3-pyridazinyl]thio]-N-(2-oxolanylmethyl)acetamide | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| 2-[[1-(4-fluorophenyl)-4-pyrazolo[3,4-d]pyrimidinyl]thio]-N-(2-oxolanylmethyl)acetamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[3-[6-(1-azepanyl)-3-pyridazinyl]phenyl]-4-methylbenzenesulfonamide | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| N-[1-(3-fluorophenyl)-6,6-dimethyl-5,7-dihydro-4H-indazol-4-yl]-2-(2-pyridinylthio)acetamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[1-(2,3-dimethylphenyl)-4,5,6,7-tetrahydroindazol-4-yl]-2,5-dimethyl-3-pyrazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[1-(4-tert-butylphenyl)-4,5,6,7-tetrahydroindazol-4-yl]-4-methyl-5-thiadiazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| dafadine O | [no description available] | low | 0 | 0 | aromatic amide; aromatic ether; isoxazoles; N-acylpiperidine; pyridines; ring assembly | P450 inhibitor |
| N-[1-(3,4-dimethylphenyl)-4,5,6,7-tetrahydroindazol-4-yl]-2,5-dimethyl-3-pyrazolecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[1-(3,4-dimethylphenyl)-4,5,6,7-tetrahydroindazol-4-yl]-5-(methoxymethyl)-2-furancarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| N-[1-(3,4-dimethylphenyl)-4,5,6,7-tetrahydroindazol-4-yl]-2-(3,5-dimethyl-1-pyrazolyl)acetamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| cep 26401 | [no description available] | low | 0 | 0 | pyridazines; ring assembly | |
| cym-5442 | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| 4-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| bms 708163 | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| gsk 1070916 | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| difenacoum | [no description available] | low | 0 | 0 | benzenes; naphthalenes; ring assembly | |
| bromfenacoum | [no description available] | low | 0 | 0 | benzenes; naphthalenes; ring assembly | |
| flocoumafen | [no description available] | low | 0 | 0 | benzenes; naphthalenes; ring assembly | |
| gs-5816 | [no description available] | low | 0 | 0 | carbamate ester; ether; imidazoles; L-valine derivative; N-acylpyrrolidine; organic heteropentacyclic compound; ring assembly | antiviral drug; hepatitis C virus nonstructural protein 5A inhibitor |
| mk-8742 | [no description available] | low | 0 | 0 | carbamate ester; imidazoles; L-valine derivative; N-acylpyrrolidine; organic heterotetracyclic compound; ring assembly | antiviral drug; hepatitis C virus nonstructural protein 5A inhibitor; hepatoprotective agent |
| N-[3-[(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)amino]-1-isoindolylidene]-2-thiophenecarboxamide | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 3-(4-methoxyphenyl)-1-methyl-1H-1,2,4-triazol-5-ol | [no description available] | low | 0 | 0 | ring assembly; triazoles | |
| 3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6-diol | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| 4-methyl-3-phenyl-1,2-dihydropyrazolo[3,4-b]pyridin-6-one | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| scytonemin | [no description available] | low | 0 | 0 | enone; organic heterotricyclic compound; organonitrogen heterocyclic compound; polyphenol; ring assembly | bacterial metabolite; biological pigment; ultraviolet filter |
| 5-(4-chlorophenyl)-3-(4-nitrophenyl)-1H-pyrazole | [no description available] | low | 0 | 0 | pyrazoles; ring assembly | |
| sta 9090 | [no description available] | low | 0 | 0 | ring assembly; triazoles | |
| opicapone | [no description available] | low | 0 | 0 | oxadiazole; ring assembly | |
| am 251 | [no description available] | low | 0 | 0 | amidopiperidine; carbohydrazide; dichlorobenzene; organoiodine compound; pyrazoles | antidepressant; antineoplastic agent; apoptosis inducer; CB1 receptor antagonist |
| celecoxib | [no description available] | low | 0 | 0 | organofluorine compound; pyrazoles; sulfonamide; toluenes | cyclooxygenase 2 inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug |
| dipyrone | [no description available] | low | 0 | 0 | amino sulfonic acid; pyrazoles | anti-inflammatory agent; antipyretic; antirheumatic drug; cyclooxygenase 3 inhibitor; non-narcotic analgesic; peripheral nervous system drug; prodrug |
| fipronil | [no description available] | low | 0 | 0 | (trifluoromethyl)benzenes; dichlorobenzene; nitrile; primary amino compound; pyrazoles; sulfoxide | |
| fomepizole | [no description available] | low | 0 | 0 | pyrazoles | antidote; EC 1.1.1.1 (alcohol dehydrogenase) inhibitor; protective agent |
| sulfaphenazole | [no description available] | low | 0 | 0 | primary amino compound; pyrazoles; substituted aniline; sulfonamide antibiotic; sulfonamide | antibacterial drug; EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor; EC 1.14.13.67 (quinine 3-monooxygenase) inhibitor; P450 inhibitor |
| betazole | [no description available] | low | 0 | 0 | primary amino compound; pyrazoles | diagnostic agent; gastrointestinal drug; histamine agonist |
| 5-methylpyrazole-3-carboxylic acid | [no description available] | low | 0 | 0 | monocarboxylic acid; pyrazoles | metabolite |
| noramidopyrine | [no description available] | low | 0 | 0 | pyrazoles; secondary amino compound | antipyretic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug; opioid analgesic; peripheral nervous system drug |
| metazachlor | [no description available] | low | 0 | 0 | aromatic amide; organochlorine compound; pyrazoles | environmental contaminant; herbicide; xenobiotic |
| tepoxalin | [no description available] | low | 0 | 0 | aromatic ether; hydroxamic acid; monochlorobenzenes; pyrazoles | antipyretic; apoptosis inhibitor; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; immunomodulator; lipoxygenase inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug |
| n-acetylaminoantipyrine | [no description available] | low | 0 | 0 | acetamides; pyrazoles | drug metabolite; marine xenobiotic metabolite |
| lonazolac | [no description available] | low | 0 | 0 | monocarboxylic acid; monochlorobenzenes; pyrazoles | antineoplastic agent; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug |
| 4-iodopyrazole | [no description available] | low | 0 | 0 | organoiodine compound; pyrazoles | |
| ethyl 5-(4,6-dimethoxypyrimidin-2-ylcarbamoylsulfamoyl)-1-methylpyrazole-4-carboxylate | [no description available] | low | 0 | 0 | pyrazoles | |
| halosulfuron methyl | [no description available] | low | 0 | 0 | pyrazoles | |
| pyraclofos | [no description available] | low | 0 | 0 | monochlorobenzenes; organic thiophosphate; organochlorine insecticide; organosulfur compound; organothiophosphate insecticide; pyrazoles | agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor |
| sr141716 | [no description available] | low | 0 | 0 | amidopiperidine; carbohydrazide; dichlorobenzene; monochlorobenzenes; pyrazoles | anti-obesity agent; appetite depressant; CB1 receptor antagonist |
| sc 58125 | [no description available] | low | 0 | 0 | organofluorine compound; pyrazoles; sulfone | antineoplastic agent; cyclooxygenase 2 inhibitor |
| birb 796 | [no description available] | low | 0 | 0 | aromatic ether; morpholines; naphthalenes; pyrazoles; ureas | EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; immunomodulator |
| 1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea | [no description available] | low | 0 | 0 | monochlorobenzenes; phenylureas; pyrazoles | EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor |
| hts 466284 | [no description available] | low | 0 | 0 | pyrazoles; pyridines; quinolines | TGFbeta receptor antagonist |
| 3-pentyl-4,5,6,7-tetrahydro-1H-indazole | [no description available] | low | 0 | 0 | pyrazoles | |
| 5-(2-methylpropyl)-1H-pyrazole-3-carboxylic acid | [no description available] | low | 0 | 0 | pyrazoles | |
| N-(cyclopentylideneamino)-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide | [no description available] | low | 0 | 0 | aromatic amide; pyrazoles | |
| N-(4,5-dihydrothiazol-2-yl)-1-ethyl-3-pyrazolecarboxamide | [no description available] | low | 0 | 0 | aromatic amide; pyrazoles | |
| 1-[[(1,3-dimethyl-4-pyrazolyl)-oxomethyl]amino]-3-(4-methylphenyl)thiourea | [no description available] | low | 0 | 0 | aromatic amide; pyrazoles | |
| cct018159 | [no description available] | low | 0 | 0 | benzodioxine; pyrazoles; resorcinols | antineoplastic agent; apoptosis inducer; Hsp90 inhibitor |
| 1-[4-(2-fluorophenyl)-2-thiazolyl]-5-(trifluoromethyl)-4-pyrazolecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | pyrazoles | |
| 2,2,2-trifluoro-N-(5-oxo-1-phenyl-4H-pyrazol-3-yl)acetamide | [no description available] | low | 0 | 0 | pyrazoles; secondary carboxamide; trifluoroacetamide | |
| 5-chloro-1-[(2-chlorophenyl)methyl]-3-methyl-4-pyrazolecarboxylic acid [2-[(5-methyl-3-isoxazolyl)amino]-2-oxoethyl] ester | [no description available] | low | 0 | 0 | pyrazoles | |
| 3-(tert-butyl)-1-methyl-4,5-dihydro-1H-pyrazol-5-one | [no description available] | low | 0 | 0 | pyrazoles | |
| ethyl 1-[4-(4-chlorobenzenesulfonamido)phenyl]-5-(trifluoromethyl)pyrazole-4-carboxylate | [no description available] | low | 0 | 0 | ethyl ester; monochlorobenzenes; organofluorine compound; pyrazoles; sulfonamide | |
| deracoxib | [no description available] | low | 0 | 0 | organofluorine compound; pyrazoles; sulfonamide | cyclooxygenase 2 inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug |
| fipronil sulfone | [no description available] | low | 0 | 0 | (trifluoromethyl)benzenes; dichlorobenzene; nitrile; pyrazoles; sulfone | marine xenobiotic metabolite |
| sr 144528 | [no description available] | low | 0 | 0 | bridged compound; monochlorobenzenes; pyrazoles; secondary carboxamide | CB2 receptor antagonist; EC 2.3.1.26 (sterol O-acyltransferase) inhibitor |
| 2-[[3-methyl-5-oxo-1-(phenylmethyl)-4H-pyrazol-4-yl]-phenylmethyl]propanedinitrile | [no description available] | low | 0 | 0 | pyrazoles | |
| 5-tert-butyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid | [no description available] | low | 0 | 0 | pyrazoles | |
| 1-[2-(1-oxo-2-thiophen-2-ylethoxy)ethyl]-5-[(1-oxo-2-thiophen-2-ylethyl)amino]-4-pyrazolecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | pyrazoles | |
| N1',N6'-bis[(5-methyl-1H-pyrazol-3-yl)-oxomethyl]hexanedihydrazide | [no description available] | low | 0 | 0 | aromatic amide; pyrazoles | |
| sc 560 | [no description available] | low | 0 | 0 | aromatic ether; monochlorobenzenes; organofluorine compound; pyrazoles | angiogenesis modulating agent; antineoplastic agent; apoptosis inducer; cyclooxygenase 1 inhibitor; non-steroidal anti-inflammatory drug |
| ver-49009 | [no description available] | low | 0 | 0 | aromatic amide; monochlorobenzenes; monomethoxybenzene; pyrazoles; resorcinols | Hsp90 inhibitor |
| 5-methyl-2-phenyl-4-propan-2-ylidene-3-pyrazolone | [no description available] | low | 0 | 0 | pyrazoles | |
| 1,3,5-tris(4-hydroxyphenyl)-4-propyl-1h-pyrazole | [no description available] | low | 0 | 0 | phenols; pyrazoles | estrogen receptor agonist |
| N-(2-methoxyethyl)-2-(5-methyl-4,5,6,7-tetrahydroindazol-2-yl)acetamide | [no description available] | low | 0 | 0 | pyrazoles | |
| GSK3-XIII | [no description available] | low | 0 | 0 | aromatic amine; pyrazoles; quinazolines; secondary amino compound | EC 2.7.11.26 (tau-protein kinase) inhibitor |
| pyrachlostrobin | [no description available] | low | 0 | 0 | aromatic ether; carbamate ester; carbanilate fungicide; methoxycarbanilate strobilurin antifungal agent; monochlorobenzenes; pyrazoles | antifungal agrochemical; environmental contaminant; mitochondrial cytochrome-bc1 complex inhibitor; xenobiotic |
| 4-(5-(4-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazol-1-yl)benzenesulfonamide | [no description available] | low | 0 | 0 | organofluorine compound; pyrazoles; sulfonamide | cyclooxygenase 2 inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug |
| sd 0006 | [no description available] | low | 0 | 0 | monochlorobenzenes; N-acylpiperidine; primary alcohol; pyrazoles; pyrimidines | |
| osu 03012 | [no description available] | low | 0 | 0 | antibiotic antifungal drug; aromatic amide; glycine derivative; organofluorine compound; phenanthrenes; pyrazoles | antineoplastic agent; apoptosis inducer; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor |
| at 7867 | [no description available] | low | 0 | 0 | monochlorobenzenes; piperidines; pyrazoles | antineoplastic agent; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor |
| chlorantranilipole | [no description available] | low | 0 | 0 | monochlorobenzenes; organobromine compound; pyrazole insecticide; pyrazoles; pyridines; secondary carboxamide | ryanodine receptor agonist |
| at 7519 | [no description available] | low | 0 | 0 | dichlorobenzene; piperidines; pyrazoles; secondary carboxamide | antineoplastic agent; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor |
| penthiopyrad | [no description available] | low | 0 | 0 | aromatic amide; organofluorine compound; pyrazoles; thiophenes | |
| azd 1152 | [no description available] | low | 0 | 0 | anilide; monoalkyl phosphate; monofluorobenzenes; pyrazoles; quinazolines; secondary amino compound; secondary carboxamide; tertiary amino compound | antineoplastic agent; Aurora kinase inhibitor; prodrug |
| 5-fluoro-1,3-dimethyl-N-[2-(4-methylpentan-2-yl)phenyl]pyrazole-4-carboxamide | [no description available] | low | 0 | 0 | aromatic amide; organofluorine compound; pyrazoles | |
| GDC-0879 | [no description available] | low | 0 | 0 | indanes; ketoxime; primary alcohol; pyrazoles; pyridines | antineoplastic agent; B-Raf inhibitor |
| azd 1152-hqpa | [no description available] | low | 0 | 0 | anilide; monofluorobenzenes; primary alcohol; pyrazoles; quinazolines; secondary amino compound; secondary carboxamide; tertiary amino compound | antineoplastic agent; Aurora kinase inhibitor |
| fluxapyroxad | [no description available] | low | 0 | 0 | anilide fungicide; aromatic amide; biphenyls; pyrazoles; trifluorobenzene | antifungal agrochemical; EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor |
| cyenopyrafen | [no description available] | low | 0 | 0 | nitrile; pivalate ester; pyrazoles | agrochemical; proacaricide |
| sgx 523 | [no description available] | low | 0 | 0 | aryl sulfide; biaryl; pyrazoles; quinolines; triazolopyridazine | c-Met tyrosine kinase inhibitor; nephrotoxic agent |
| bms 754807 | [no description available] | low | 0 | 0 | pyrazoles; pyridines; pyrrolidines; pyrrolotriazine | antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor |
| dcc-2036 | [no description available] | low | 0 | 0 | organofluorine compound; phenylureas; pyrazoles; pyridinecarboxamide; quinolines | tyrosine kinase inhibitor |
| incb-018424 | [no description available] | low | 0 | 0 | nitrile; pyrazoles; pyrrolopyrimidine | antineoplastic agent; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor |
| baricitinib | [no description available] | low | 0 | 0 | azetidines; nitrile; pyrazoles; pyrrolopyrimidine; sulfonamide | anti-inflammatory agent; antirheumatic drug; antiviral agent; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; immunosuppressive agent |
| gsk-5498a | [no description available] | low | 0 | 0 | (trifluoromethyl)benzenes; difluorobenzene; pyrazoles; secondary carboxamide | calcium channel blocker |
| azd4547 | [no description available] | low | 0 | 0 | benzamides; N-arylpiperazine; pyrazoles | fibroblast growth factor receptor antagonist |
| N-[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methylpyrazole-4-carboxamide | [no description available] | low | 0 | 0 | aromatic amide; bridged compound; olefinic compound; organochlorine compound; organofluorine compound; pyrazoles | |
| 3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-(2,4,6-trichlorophenyl)propan-2-yl]pyrazole-4-carboxamide | [no description available] | low | 0 | 0 | aromatic amide; monocarboxylic acid amide; organofluorine compound; pyrazoles; trichlorobenzene | |
| oxathiapiprolin | [no description available] | low | 0 | 0 | 1,3-thiazoles; isoxazoline; N-acylpiperidine; organofluorine compound; pyrazoles; tertiary carboxamide | |
| LimKi 3 | [no description available] | low | 0 | 0 | 1,3-thiazoles; dichlorobenzene; organofluorine compound; pyrazoles; secondary carboxamide | LIM kinase inhibitor |
| pf-06463922 | [no description available] | low | 0 | 0 | aminopyridine; aromatic ether; azamacrocycle; benzamides; cyclic ether; monofluorobenzenes; nitrile; organic heterotetracyclic compound; pyrazoles | antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor |
| CCT251545 | [no description available] | low | 0 | 0 | azaspiro compound; chloropyridine; pyrazoles | antineoplastic agent; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor; Wnt signalling inhibitor |
| ldc4297 | [no description available] | low | 0 | 0 | aromatic ether; piperidines; pyrazoles; pyrazolotriazine; secondary amino compound | antineoplastic agent; antiviral agent; apoptosis inducer; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor |
| praliciguat | [no description available] | low | 0 | 0 | aminopyrimidine; isoxazoles; monofluorobenzenes; organofluorine compound; pyrazoles; secondary amino compound; tertiary alcohol | anti-inflammatory agent; antihypertensive agent; soluble guanylate cyclase activator; vasodilator agent |
| can 508 | [no description available] | low | 0 | 0 | aromatic amine; monoazo compound; phenols; pyrazoles | angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor |
| pyrazofurin | [no description available] | low | 0 | 0 | C-glycosyl compound; pyrazoles | antimetabolite; antimicrobial agent; antineoplastic agent; EC 4.1.1.23 (orotidine-5'-phosphate decarboxylase) inhibitor |
| hydrazinocurcumin | [no description available] | low | 0 | 0 | aromatic ether; olefinic compound; polyphenol; pyrazoles | angiogenesis modulating agent; antineoplastic agent; EC 2.3.1.48 (histone acetyltransferase) inhibitor; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor |
| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|---|---|---|---|
| Inflammation | 0 | low | 1 | 0 |
| Innate Inflammatory Response | 0 | low | 1 | 0 |