Compounds > 1,3-dimethylurea
Page last updated: 2024-12-05

1,3-dimethylurea

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

## 1,3-Dimethylurea: A Versatile Tool in Research

1,3-Dimethylurea (DMU) is an organic compound with the formula (CH3)2NCONH2. It's a white, crystalline solid that is soluble in water and many organic solvents. While not as widely known as some other research chemicals, DMU plays an important role in various scientific fields due to its unique properties and applications:

**1. Agricultural Research:**

* **Herbicide Activity:** DMU exhibits herbicidal activity, specifically against weeds like barnyardgrass and wild oats. It disrupts the photosynthetic process in plants, leading to their death. However, due to its potential environmental impact, its use as a herbicide is limited.
* **Plant Growth Regulator:** DMU can also act as a plant growth regulator, potentially influencing flowering and fruit production. This aspect requires further investigation for its potential agricultural applications.

**2. Chemical and Material Science:**

* **Chemical Synthesis:** DMU serves as a starting material for synthesizing various organic compounds, including pharmaceuticals and other specialized chemicals. Its reactivity makes it valuable in various chemical reactions.
* **Polymer Chemistry:** DMU can be incorporated into polymers, modifying their properties and providing specific functionalities. This opens doors for developing new materials with enhanced properties.

**3. Biological Research:**

* **Protein Crystallization:** DMU acts as a precipitant in protein crystallization, facilitating the formation of ordered crystals that are essential for studying protein structure and function.
* **Biocatalyst Inhibition:** Some studies suggest DMU can inhibit certain enzymes, potentially impacting biological processes. Further investigation is needed to understand its specific effects on enzymes and their implications.

**4. Environmental Research:**

* **Pollution Monitoring:** DMU can be used as a marker for wastewater contamination, as it is present in certain industrial processes. This aids in monitoring and mitigating environmental pollution.
* **Bioremediation Studies:** DMU is a potential target for bioremediation processes, exploring the use of microorganisms to degrade it and reduce its environmental impact.

**Importance for Research:**

The diverse properties and applications of 1,3-dimethylurea make it a valuable research tool across multiple disciplines.

* **Understanding its mechanism of action:** Further research into the exact mechanisms by which DMU exerts its effects in various contexts is crucial for optimizing its applications and mitigating potential risks.
* **Developing new applications:** Exploring the potential of DMU in new areas, such as novel materials synthesis and specific biological targets, holds promise for future scientific advancements.
* **Assessing its environmental impact:** Understanding the environmental fate and impact of DMU is essential for responsible use and minimizing potential risks.

In summary, 1,3-dimethylurea is a versatile compound with significant potential in various research fields. Further investigation into its properties and applications will continue to expand its use and contribute to scientific progress.

N,N'-dimethylurea : A member of the class of ureas that is urea substituted by methyl groups at positions 1 and 3. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID7293
CHEMBL ID1234380
CHEBI ID80472
MeSH IDM0069625

Synonyms (74)

Synonym
CHEMBL1234380
chebi:80472 ,
urea, 1,3-dimethyl-
nsc24823
nsc-24823
sym-dimethylurea
urea,n'-dimethyl-
96-31-1
1,3-dimethylurea
nsc-14910
wln: 1mvm1
urea,3-dimethyl-
symmetric dimethylurea
nsc14910
n,n'-dimethylharnstoff
n,n'-dimethylurea
DMU ,
inchi=1/c3h8n2o/c1-4-3(6)5-2/h1-2h3,(h2,4,5,6
urea,1,3-dimethyl
urea, n,n'-dimethyl-
1.3-dimethylurea
ai3-24386
brn 1740672
n,n'-dimethylharnstoff [german]
nsc 14910
einecs 202-498-7
ccris 2509
hsdb 3423
n,n'-dimethylurea, (sym.), >=95.0% (hplc), technical
n,n'-dimethylurea, (sym.), >=99% (from n)
D0289
1,3-dimethylcarbamide
BMSE000248
AKOS000120912
1,3-dimethylurea;n,n'-dimethylurea
A845576
A4569
NCGC00248834-01
wam6dr9i4x ,
unii-wam6dr9i4x
ec 202-498-7
dtxsid5025156 ,
tox21_200794
NCGC00258348-01
cas-96-31-1
dtxcid605156
BBL011513
STL146629
FT-0606700
1,3-dimethylurea [hsdb]
dimethyl urea [inci]
dimethylurea, n,n'-
ethyl 5-oxo-2,3-diphenyl-cyclopentanecarboxylate
3K3G
1,3 dimethyl urea
1,3-dimethyl urea
n,n'-dimethyl urea
W-100145
1,1'-dimethylurea
(ch3nh)2co
mfcd00008286
1,3-dimethylurea, 98%
F0001-2292
n,n'-dimethylurea, pestanal(r), analytical standard
n,n'-dimethylurea, ~98%
dimethylharnstoff
n,n-dimethyl-urea
SY004507
n,n inverted exclamation mark -dimethylurea
Q419740
CS-W013749
EN300-20740
P17517
PB47928
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
ureas
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
caffeine degradation V (bacteria, via trimethylurate)119

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Urea transporterNitratidesulfovibrio vulgaris str. HildenboroughIC50 (µMol)1,400.00001,400.00001,400.00001,400.0000AID977608
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID977608Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB2009Nature, Dec-10, Volume: 462, Issue:7274
Crystal structure of a bacterial homologue of the kidney urea transporter.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (30.77)18.7374
1990's0 (0.00)18.2507
2000's3 (23.08)29.6817
2010's6 (46.15)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 37.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index37.66 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.40 (4.65)
Search Engine Demand Index34.82 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (37.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bromide
Bromides: Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)		2.0610halide anion;
monoatomic bromine
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		2.0610halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
glycine
[no description available]		1.9510alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
iodine
Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.. diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..		2.0610diatomic iodinenutrient
niacinamide
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.		2.0510pyridine alkaloid;
pyridinecarboxamide;
vitamin B3		anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor
nitrates
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.		2.0610monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species
pyrazinamide
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.		7.1110monocarboxylic acid amide;
N-acylammonia;
pyrazines		antitubercular agent;
prodrug
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		3.0950isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
guanidine
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.. guanidine : An aminocarboxamidine, the parent compound of the guanidines.		1.9710carboxamidine;
guanidines;
one-carbon compound
phenylmethylsulfonyl fluoride
Phenylmethylsulfonyl Fluoride: An enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.. phenylmethanesulfonyl fluoride : An acyl fluoride with phenylmethanesulfonyl as the acyl group.		1.9710acyl fluorideserine proteinase inhibitor
phloretin
[no description available]		2.4420dihydrochalconesantineoplastic agent;
plant metabolite
alloxan
Alloxan: Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.. alloxan : A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.		1.9510pyrimidonehyperglycemic agent;
metabolite
carbachol
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.		2.0510ammonium salt;
carbamate ester		cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic
n-vinyl-2-pyrrolidinone
N-vinyl-2-pyrrolidinone: monomer of POVIDONE; structure given in first source		2.1110pyrrolidin-2-ones
1,1-dimethylurea
[no description available]		1.9510
methyl isocyanate
methyl isocyanate: structure. methyl isocyanate : The isocyanate that is methane modified by a single isocyanato substituent.		2.1110isocyanatesallergen;
apoptosis inducer
paraquat
Paraquat: A poisonous dipyridilium compound used as contact herbicide. Contact with concentrated solutions causes irritation of the skin, cracking and shedding of the nails, and delayed healing of cuts and wounds.. paraquat : An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.		1.9610organic cationgeroprotector;
herbicide
vasotocin
Vasotocin: A nonapeptide that contains the ring of OXYTOCIN and the side chain of ARG-VASOPRESSIN with the latter determining the specific recognition of hormone receptors. Vasotocin is the non-mammalian vasopressin-like hormone or antidiuretic hormone regulating water and salt metabolism.. vasotocin : A heterodetic cyclic peptide that is homologous to oxytocin and vasopressin. It is a pituitary hormone that acts as an endocrine regulator for water balance, osmotic homoeostasis and is involved in social and sexual behavior in non-mammalian vertebrates.		2.0310
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		2.0510acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
fluorides
[no description available]		2.0610halide anion;
monoatomic fluorine
cyanates
Cyanates: Organic salts of cyanic acid containing the -OCN radical.. cyanates : Salts and esters of cyanic acid, HOC#N; compounds carrying the cyanate functional group -O-C#N.. isocyanates : Organonitrogen compounds that are derivatives of isocyanic acid; compounds containing the isocyanate functional group -N=C=O (as opposed to the cyanate group, -O-C#N).		2.1110
h 89
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide: structure given in first source. N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide : A member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N(1)-[3-(4-bromophenyl)prop-2-en-1-yl]ethane-1,2-diamine. It is a protein kinase A inhibitor.. (E)-N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide : A N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide in which the double bond adopts a trans-configuration.		2.0310N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide
arginine vasopressin
Arginine Vasopressin: The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.. argipressin : The predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6.		2.0510vasopressincardiovascular drug;
hematologic agent;
mitogen
thionicotinamide
[no description available]		2.0510
thiourea
Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.		1.9510one-carbon compound;
thioureas;
ureas		antioxidant;
chromophore
alpha-chymotrypsin
Chymotrypsin: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.		1.9710
fumarates
Fumarates: Compounds based on fumaric acid.. fumarate(2-) : A C4-dicarboxylate that is the E-isomer of but-2-enedioate(2-)		1.9510butenedioate;
C4-dicarboxylate		human metabolite;
metabolite;
Saccharomyces cerevisiae metabolite
dihydroxyfumarate
dihydroxyfumarate: RN given refers to ((E)-isomer); structure. dihydroxyfumaric acid : A 2-hydroxydicarboxylic acid consisting of fumaric acid having two hydroxy groups at the 2- and 3-positions.		1.95102-hydroxydicarboxylic acid;
C4-dicarboxylic acid
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.1110
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.1110
Deficiency, Vitamin E
[description not available]		01.9610