Compounds > 1,3-diamino-2-propanol
Page last updated: 2024-12-06

1,3-diamino-2-propanol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1,3-Diamino-2-propanol, also known as **3-amino-1-propanol**, is a colorless liquid with a strong ammonia-like odor. It's a bifunctional molecule with both **amine** and **alcohol** functional groups.

**Here's why it's important for research:**

* **Versatile building block:** 1,3-Diamino-2-propanol serves as a building block for various organic compounds, particularly in the synthesis of **pharmaceuticals**, **polymers**, and **agrochemicals**. Its reactive amino and alcohol groups allow for a variety of chemical reactions, including **alkylation**, **acylation**, and **condensation**.
* **Catalyst:** It can act as a catalyst in various reactions, including **esterification** and **transesterification**. Its dual functionality allows it to participate in different stages of the reaction mechanism.
* **Drug development:** 1,3-Diamino-2-propanol is being studied as a potential precursor for the development of new **drugs**, particularly those targeting **central nervous system** disorders. Its structure and reactivity can be tailored to modify its pharmacological activity.
* **Material science:** It can be used to synthesize novel **polymers** with unique properties like **biocompatibility**, **biodegradability**, and **thermal stability**. These polymers have potential applications in areas like **biomedical devices**, **packaging materials**, and **adhesives**.
* **Analytical chemistry:** 1,3-Diamino-2-propanol is used in **analytical chemistry** as a **reagent** for the detection and quantification of various compounds. Its specific properties make it useful for **HPLC** (High-Performance Liquid Chromatography) and **GC** (Gas Chromatography) analysis.

**Overall, 1,3-Diamino-2-propanol's diverse reactivity and potential applications make it a valuable compound for research in a wide range of scientific fields.**

Cross-References

ID SourceID
PubMed CID61157
CHEMBL ID177097
MeSH IDM0067792

Synonyms (49)

Synonym
AC-3376
c3h10n2o
1,3-diamino-2-hydroxypropane
nsc6070
diaminoisopropanol
1,3-diamino-2-propanol
2-propanol,3-diamino-
nsc-6070
2-hydroxy-1,3-propanediamine
2-hydroxy-1,3-diaminopropane
616-29-5
1,3-diamino-2-propanol, 95%
1,3-diaminopropan-2-ol
1,3-diamino-2-hydroxy-propane
CHEMBL177097
H0497
A833340
AKOS005257033
BBL011378
ai3-15325
l59259h635 ,
unii-l59259h635
einecs 210-474-2
2-propanol, 1,3-diamino-
ec 210-474-2
nsc 6070
GEO-00920
STL146476
FT-0606610
AM20100500
(3-amino-2-hydroxypropyl)amine
1,3-diamino-propan-2-ol
2-hydroxy -1,3-diaminopropane
1,3-diamino-2-hydroxy propane
1,3 diamino-2-hydroxypropane
1,3 diamino-propan-2-ol
DTXSID3060663
STR02005
W-109577
mfcd00008142
CS-W007600
1,3-diamino-2-propanol, purum, >=98.0% (gc)
SY013661
F0001-1632
BCP18704
Q23820259
O10345
SB83765
EN300-86111
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID25063Dissociation constant (pK2)1998Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
Molecular features associated with polyamine modulation of NMDA receptors.
AID15721Calculated partition coefficient (clogP)1998Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
Molecular features associated with polyamine modulation of NMDA receptors.
AID22299Partition coefficient (logP)1998Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
Molecular features associated with polyamine modulation of NMDA receptors.
AID143006Enhanced binding of [3H]MK-801 to N-methyl-D-aspartate glutamate receptor in presence of spermine1998Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
Molecular features associated with polyamine modulation of NMDA receptors.
AID15290Percentage of the diamine which is monoprotonated at pH 7.41998Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
Molecular features associated with polyamine modulation of NMDA receptors.
AID25056Dissociation constant (pK1)1998Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
Molecular features associated with polyamine modulation of NMDA receptors.
AID143007Percent [3H]MK-801 bound to N-methyl-D-aspartate glutamate receptor in the presence of 20 uM spermine assuming 100% in the absence of added diamine.1998Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
Molecular features associated with polyamine modulation of NMDA receptors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (71.43)18.7374
1990's2 (14.29)18.2507
2000's1 (7.14)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.22

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.22 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.26 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (26.22)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
trimethylenediamine
trimethylenediamine: RN given refers to parent cpd; structure. trimethylenediamine : An alkane-alpha,omega-diamine comprising a propane skeleton with amino substituents at positions 1 and 3.		2.8840alkane-alpha,omega-diaminehuman metabolite;
mouse metabolite;
reagent
glycerol
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.		2.0410alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
putrescine
[no description available]		1.9610alkane-alpha,omega-diamineantioxidant;
fundamental metabolite
pyrogallol
benzenetriol : A triol in which three hydroxy groups are substituted onto a benzene ring.		2.1110benzenetriol;
phenolic donor		plant metabolite
spermidine
[no description available]		2.8840polyazaalkane;
triamine		autophagy inducer;
fundamental metabolite;
geroprotector
alpha-methylornithine
alpha-methylornithine: inhibitor of ornithine decarboxylase; RN given refers to cpd without isomeric designation		1.9610
eflornithine
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.. eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.		2.3620alpha-amino acid;
fluoroamino acid		trypanocidal drug
harmaline
Harmaline: A beta-carboline alkaloid isolated from seeds of PEGANUM.. harmaline : A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7 and has been reduced across the 3,4 bond.		1.9710harmala alkaloidoneirogen
mephenesin
Mephenesin: A centrally acting muscle relaxant with a short duration of action.. 1-(2-methylphenyl)glycerol : A glycerol ether in which a single 2-methylphenyl group is attached at position 1 of glycerol via an ether linkage.		6.9310aromatic ether;
glycerol ether
phenobarbital
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.		1.9510barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
sebacic acid
sebacic acid : An alpha,omega-dicarboxylic acid that is the 1,8-dicarboxy derivative of octane.		2.0410alpha,omega-dicarboxylic acid;
dicarboxylic fatty acid		human metabolite;
plant metabolite
benz(a)anthracene
benz(a)anthracene: 4 fused rings of which one is angular in contrast to the linear NAPHTHACENES. tetraphene : An angular ortho-fused polycyclic arene consisting of four fused benzene rings.		1.9610ortho-fused polycyclic arene;
tetraphenes
leucine
Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.		1.9710amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
ornithine
Ornithine: An amino acid produced in the urea cycle by the splitting off of urea from arginine.. ornithine : An alpha-amino acid that is pentanoic acid bearing two amino substituents at positions 2 and 5.		2.8840non-proteinogenic L-alpha-amino acid;
ornithine		algal metabolite;
hepatoprotective agent;
mouse metabolite
isoprene
isoprene: used in manufacture of ''synthetic'' rubber, butyl rubber; copolymer in production of elastomers; structure. isoprene : A hemiterpene with the formula CH2=C(CH3)CH=CH2; the monomer of natural rubber and a common structure motif to the isoprenoids, a large class of other naturally occurring compounds.		2.0410alkadiene;
hemiterpene;
volatile organic compound		plant metabolite
gramine
gramine : An aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3.		1.9710aminoalkylindole;
indole alkaloid;
tertiary amino compound		antibacterial agent;
antiviral agent;
plant metabolite;
serotonergic antagonist
salicylaldehyde
o-hydroxybenzaldehyde: structure in first source		2.1110hydroxybenzaldehydenematicide;
plant metabolite
threitol
threitol: RN given refers to (R*,R*)-isomer. D-threitol : The D-enantiomer of threitol.		2.0410threitolhuman metabolite
4-aminopiperidine
4-aminopiperidine: structure in first source		1.9910
mitoguazone
Mitoguazone: Antineoplastic agent effective against myelogenous leukemia in experimental animals. Also acts as an inhibitor of animal S-adenosylmethionine decarboxylase.. mitoguazone : A hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine.		1.9510guanidines;
hydrazone		antineoplastic agent;
apoptosis inducer;
EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		1.9510benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
Palsy
[description not available]		01.9310
Paralysis
A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)		06.9310
Alloxan Diabetes
[description not available]		01.9610
Carcinoma, Ehrlich Tumor
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.		02.6530