Page last updated: 2024-12-09

1,3-Dimethoxy-2-(methylthio)benzene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1,3-Dimethoxy-2-(methylthio)benzene, also known as **2-methylthioresorcinol dimethyl ether**, is an organic compound with the chemical formula C9H12O2S.

**Structure and Properties:**

* It is a colorless to pale yellow solid with a distinct odor.
* It is a derivative of resorcinol, a phenolic compound with two hydroxyl groups.
* The molecule contains two methoxy groups (OCH3) at positions 1 and 3 and a methylthio group (SCH3) at position 2.

**Research Importance:**

1,3-Dimethoxy-2-(methylthio)benzene is important for research due to its diverse applications, including:

* **Synthesis of Pharmaceuticals:** It is a precursor to various pharmacologically active compounds, particularly those with anti-inflammatory and analgesic properties.
* **Organic Synthesis:** It serves as a starting material for the preparation of other organic compounds, particularly thioethers and sulfides.
* **Materials Science:** It has potential applications in the development of new polymers, resins, and adhesives.
* **Chemical Biology:** It can be used as a probe to study the structure and function of enzymes and other biological targets.

**Specific Research Areas:**

* **Anti-Inflammatory Agents:** Studies have shown that derivatives of 1,3-Dimethoxy-2-(methylthio)benzene exhibit anti-inflammatory activity, potentially through inhibition of enzymes involved in inflammation pathways.
* **Anti-Cancer Agents:** Certain derivatives have shown promising anti-cancer activity in preclinical studies.
* **Neuroprotective Agents:** Research is exploring the potential of this compound and its derivatives as neuroprotective agents for conditions like Alzheimer's and Parkinson's diseases.

**Overall, 1,3-Dimethoxy-2-(methylthio)benzene remains an important research compound due to its potential for the development of new drugs, materials, and biological probes.**

Cross-References

ID SourceID
PubMed CID603551
CHEBI ID194711
SCHEMBL ID4311047

Synonyms (20)

Synonym
IDI1_031474
1,3-dimethoxy-2-(methylthio)benzene
benzene, 1,3-dimethoxy-2-(methylthio)-
inchi=1/c9h12o2s/c1-10-7-5-4-6-8(11-2)9(7)12-3/h4-6h,1-3h
MAYBRIDGE4_000892
HMS1523I12
1,3-dimethoxy-2-methylsulanylbenzene
CHEBI:194711
1,3-dimethoxy-2-methylsulfanylbenzene
AKOS006229028
33617-67-3
FT-0606674
benzene,1,3-dimethoxy-2-(methylthio)-
SCHEMBL4311047
1,3-dimethoxy-2-(methylsulfanyl)benzene #
DTXSID40345301
1,3-dimethoxy-2-(methylthio)benzene, aldrichcpr
mfcd00010334
(2,6-dimethoxyphenyl)(methyl)sulfane
AS-82083
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
dimethoxybenzeneAny methoxybenzene that consists of a benzene skeleton substituted with two methoxy groups and its derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.13 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]