Compounds > 1,3,5(10)-estratriene
Page last updated: 2024-12-08

1,3,5(10)-estratriene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1,3,5(10)-estratriene is not a standard chemical name. It likely refers to a **steroid** with a specific structure. Here's a breakdown of the name and its potential significance in research:

* **Estratriene**: This part suggests a steroid molecule with three double bonds (triene).
* **1,3,5(10)**: This denotes the position of these double bonds on the steroid ring system.

**Possible Interpretations & Significance:**

1. **Estrone**: The most likely candidate for the described structure is estrone, a naturally occurring estrogen hormone. Estrogens play critical roles in:
* **Female reproductive development and function**: Regulation of menstrual cycles, pregnancy, and secondary sex characteristics.
* **Bone health**: Estrogen helps maintain bone density.
* **Cardiovascular health**: It can have protective effects on the heart.
* **Brain function**: Estrogen influences mood, memory, and cognitive function.

2. **Synthetic Estrogens**: This could also refer to a synthetic estrogen derivative with a similar structure. Synthetic estrogens have various applications, including:
* **Hormone replacement therapy (HRT)** for menopausal symptoms.
* **Contraception**: Some birth control pills contain synthetic estrogens.
* **Treatment of hormone-dependent cancers**: Estrogen antagonists or inhibitors are used in treating certain cancers.

**Research Importance:**

* **Understanding Estrogen's Mechanisms**: Scientists study the structure and function of estrogens to understand their intricate roles in the body. This knowledge is crucial for:
* Developing better HRT treatments.
* Designing new contraceptives with fewer side effects.
* Creating targeted therapies for estrogen-sensitive cancers.
* **Developing New Drugs**: Research into the molecular interactions of estrogens with their receptors is vital for:
* Designing new drugs that mimic or block estrogen activity.
* Identifying novel drug targets for treating a range of conditions.

**Clarification:**

To be certain about the specific structure and importance of 1,3,5(10)-estratriene, more context is needed. For example, it's helpful to know:

* The source of this name (e.g., research paper, chemical database).
* The intended application or research area.

With more information, it's possible to accurately identify the compound and discuss its relevance in greater detail.

Cross-References

ID SourceID
PubMed CID150899
CHEMBL ID1627934
MeSH IDM0088434

Synonyms (13)

Synonym
estratriene
1217-09-0
BIDD:ER0025 ,
1,3,5(10)-estratriene
(8s,9s,13s,14s)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene
CHEMBL1627934
estra-1,3,5(10)-triene
f274x7vr4m ,
unii-f274x7vr4m
1,3,5(10)-oestratriene
DTXSID10923933
estrin (compound)
[(3as,3bs,9bs,11as)-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h,11ah-cyclopenta[a]phenanthren-11a-yl]methane
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID68899Estrogen receptor (ER) binding affinity1997Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
Induction of the estrogen specific mitogenic response of MCF-7 cells by selected analogues of estradiol-17 beta: a 3D QSAR study.
AID103554Growth response in cultures of MCF-7 (human breast cancer cell line) cells1997Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
Induction of the estrogen specific mitogenic response of MCF-7 cells by selected analogues of estradiol-17 beta: a 3D QSAR study.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.38 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.18 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
estriol
hormonin: estrogen replacement; each tablet contains 600 ug micronized 17beta-estradiol, 270 ug estriol and 1.4 mg estrone. chlorapatite : A phosphate mineral with the formula Ca5(PO4)3Cl.		1.991016alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid		estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite
estrone
Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.		2.352017-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols		antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite
17-desoxyestradiol
estra-1,3,5(10)-trien-3-ol : A 3-hydroxy steroid resulting from deoxygenation at position 17 of estradiol or estrone.		1.99103-hydroxy steroid;
phenolic steroid;
phenols		estrogen
isobutyric acid
isobutyric acid: RN given refers to parent cpd. isobutyric acid : A branched fatty acid comprising propanoic acid carrying a methyl branch at C-2.		6.9310branched-chain saturated fatty acid;
fatty acid 4:0;
methyl-branched fatty acid		Daphnia magna metabolite;
plant metabolite;
volatile oil component
nandrolone
Nandrolone: C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less one carbon at the 19 position.. nandrolone : A 3-oxo Delta(4)-steroid that is estr-4-en-3-one substituted by a beta-hydroxy group at position 17.		1.941017beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
anabolic androgenic steroid		human metabolite
5 alpha-androstane-3 alpha,17 beta-diol
5alpha-androstane-3alpha,17beta-diol : The 5alpha-stereoisomer of androstane-3alpha,17beta-diol.		1.9910androstane-3alpha,17beta-diolDaphnia magna metabolite;
human metabolite
6-ketoestradiol
[no description available]		1.9910
estradiol-16
estradiol-16: RN given refers to the (16alpha)-isomer; RN for cpd without isomeric designation not avail 3/90		1.9910
alfatradiol
alfatradiol: used for treating androgenetic alopecia. 17alpha-estradiol : An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer).		1.991017alpha-hydroxy steroid;
3-hydroxy steroid;
estradiol		estrogen;
geroprotector
5 alpha-androstane-3 beta,17 beta-diol
5alpha-androstane-3beta,17beta-diol : An androstane-3,17-diol that is 5alpha-androstane substituted by beta-hydroxy groups at positions 3 and 17. It is a metabolite of dihydrotestosterone.		1.991017beta-hydroxy steroid;
3beta-hydroxy steroid;
androstane-3,17-diol		Daphnia magna metabolite;
human metabolite
17-dihydroequilenin
17-dihydroequilenin: RN given refers to (17 beta)-isomer		1.9910
6alpha-hydroxy-17beta-estradiol
6alpha-hydroxy-17beta-estradiol : A 4-hydroxy steroid that consists of 17beta-estradiol bearing an additional 6alpha-hydroxy substituent.		1.99106alpha-hydroxy steroid
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		01.9910
Breast Neoplasms
Tumors or cancer of the human BREAST.		01.9910
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9410