1,25(oh)2-16-ene-23-yne-26,27-hexafluoro-19-nor-d3

Description

The chemical name you provided, **1,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3**, describes a complex and highly modified steroid molecule. Let's break down its components:

* **1,25(OH)2:** This indicates that the molecule has hydroxyl groups (OH) attached at the 1st and 25th carbon positions. This is characteristic of **vitamin D3**, which is essential for calcium absorption and bone health.
* **16-ene:** The presence of a double bond at the 16th carbon position.
* **23-yne:** This denotes a triple bond at the 23rd carbon position.
* **26,27-hexafluoro:** The 26th and 27th carbon positions have six fluorine atoms attached.
* **19-nor:** This indicates that the 19th carbon atom is missing, making it a nor derivative.
* **D3:** This signifies that the molecule is a derivative of vitamin D3, also known as cholecalciferol.

**In summary, this complex molecule is a highly modified vitamin D3 analog with several structural alterations, including double and triple bonds, fluorine substitutions, and a missing carbon atom.**

**Why is it important for research?**

Modified vitamin D3 analogs are extensively researched for their potential therapeutic applications due to their unique properties. They may exhibit:

* **Increased potency:** Certain modifications can enhance the molecule's activity, making it more effective at its target receptors.
* **Improved bioavailability:** Changes in the molecule's structure can improve its absorption and distribution in the body.
* **Longer half-life:** Some modifications can increase the time the molecule stays active in the body, leading to more sustained effects.
* **Selective activity:** Specific modifications can target certain receptors or tissues, potentially minimizing unwanted side effects.

**This particular molecule, with its unusual combination of modifications, could be investigated for its potential in treating various conditions, including:**

* **Bone diseases:** Vitamin D3 is crucial for bone health, and analogs with improved activity could be beneficial for osteoporosis and other bone disorders.
* **Autoimmune diseases:** Vitamin D3 analogs have shown promise in modulating immune responses, potentially making them useful in managing autoimmune conditions like rheumatoid arthritis.
* **Cancer:** Some vitamin D3 analogs have demonstrated anticancer activity, warranting further investigation for their potential as anti-cancer agents.

**It's important to note that this specific molecule's research history and potential applications are not readily available without further information or specific scientific publications.** However, the structural features of this complex molecule suggest its potential for investigation in the context of vitamin D3 research and development.

1,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3: a vitamin D analog; Ro 26-2198 is the (23Z)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]