1,2-hexadecanediamine profile

## 1,2-Hexadecanediamine: A Versatile Building Block

1,2-Hexadecanediamine is a **diamine**, a molecule with two amine (NH2) groups. Its chemical formula is **CH3(CH2)14CH(NH2)CH2NH2**. It is a **long-chain**, **aliphatic** compound, meaning it contains a straight chain of carbon atoms with no double or triple bonds.

**Importance in Research:**

1,2-Hexadecanediamine is gaining importance in research due to its potential applications in various fields, including:

**1. Polymer Science:**

* **Polyamides (Nylons):** It can be used as a monomer in the synthesis of polyamides, creating polymers with enhanced properties like improved tensile strength, heat resistance, and biocompatibility.
* **Polyurethanes:** It can be used in the synthesis of polyurethanes, which find applications in foams, coatings, and elastomers.

**2. Biomaterials:**

* **Drug Delivery:** Due to its long aliphatic chain and amine groups, it can be conjugated with various drugs to create novel drug delivery systems, potentially improving drug efficacy and reducing side effects.
* **Biocompatible Coatings:** It can be used to create biocompatible coatings for medical implants, helping to reduce inflammation and improve integration with surrounding tissues.

**3. Nanotechnology:**

* **Self-Assembled Structures:** 1,2-Hexadecanediamine can be used to create self-assembled structures like micelles, vesicles, and nanotubes due to its ability to form hydrogen bonds and hydrophobic interactions.
* **Nanoparticle Synthesis:** It can be used to synthesize nanoparticles with controlled size and morphology, potentially used for applications like drug delivery, imaging, and sensing.

**4. Other Applications:**

* **Surfactants:** Its long chain and amine groups can be used to synthesize surfactants, which are used in cleaning agents, detergents, and cosmetics.
* **Corrosion Inhibitors:** It can be used as a corrosion inhibitor for metals, protecting them from oxidation and degradation.

**Overall, 1,2-hexadecanediamine serves as a versatile building block for various research areas, contributing to the development of innovative materials and technologies with promising applications in fields ranging from medicine and materials science to nanotechnology.**

**Note:** While research on 1,2-hexadecanediamine is ongoing, further investigation is needed to fully understand its potential applications and ensure its safe and effective use.

1,2-hexadecanediamine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	3469701
CHEMBL ID	39594
CHEMBL ID	473249
SCHEMBL ID	448507
MeSH ID	M0306206

Synonym
hexadecane-1,2-diamine
CHEMBL39594
bdbm50274151
hexadecane-1,2-diamine dihydrochloride
CHEMBL473249 ,
AKOS024331294
13880-36-9
1,2-hexadecanediamine
SCHEMBL448507
DTXSID60392776

Bioassays (34)

Assay ID	Title	Year	Journal	Article
AID99847	In vitro for leishmanicidal activity against Leishmania amazonensis (PH8) at the concentration of 10 ug/mL.	2002	Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4	Leishmanicidal activity of some aliphatic diamines and amino-alcohols.
AID276971	Increase in nitric oxide production in LPS-pre-stimulated rat alveolar macrophages	2006	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23	Synthesis and evaluation of some lipidic aminoalcohols and diamines as immunomodulators.
AID100127	In vitro for leishmanicidal activity against Leishmania brasiliensis (2903) at the concentration of 50 ug/mL.	2002	Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4	Leishmanicidal activity of some aliphatic diamines and amino-alcohols.
AID99855	In vitro for leishmanicidal activity against Leishmania amazonensis (PH8) at 25 ug/mL; No lysis of parasites.	2002	Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4	Leishmanicidal activity of some aliphatic diamines and amino-alcohols.
AID102528	Cytotoxicity was evaluated against lung NSCLC-N6 cell-line by MTT assay	1998	Bioorganic & medicinal chemistry letters, Jun-16, Volume: 8, Issue:12	Synthesis and in vitro cytotoxicity of lipophilic platinum(II) complexes.
AID441083	Antimycobacterial activity against Mycobacterium tuberculosis CIB99 after 5 to 7 days by microplate alamar blue assay	2009	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19	Simple dihydrosphyngosine analogues with potent activity against MDR-Mycobacterium tuberculosis.
AID100000	Tested in vitro for leishmanicidal activity against Leishmania brasiliensis (2903) at the concentration of 100 ug/mL; ++ indicates 80-90% lysis of parasites	2002	Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4	Leishmanicidal activity of some aliphatic diamines and amino-alcohols.
AID99860	In vitro for leishmanicidal activity against Leishmania amazonensis (PH8) at the concentration of 50 ug/mL.	2002	Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4	Leishmanicidal activity of some aliphatic diamines and amino-alcohols.
AID100259	Tested in vitro for leishmanicidal activity against Leishmania donovani (PP75) at the concentration of 10 ug/mL	2002	Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4	Leishmanicidal activity of some aliphatic diamines and amino-alcohols.
AID216592	In vitro inhibitory activity against human colon carcinoma WiDr cell line;	1999	Bioorganic & medicinal chemistry letters, Mar-22, Volume: 9, Issue:6	Synthesis, in vitro cytotoxicity and in vivo anti-inflammatory activity of long chain 3-amino-1,2-diols.
AID441081	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 5 to 7 days by microplate alamar blue assay	2009	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19	Simple dihydrosphyngosine analogues with potent activity against MDR-Mycobacterium tuberculosis.
AID43175	In vitro inhibitory activity against murine colon carcinoma C26-10 cell line	1999	Bioorganic & medicinal chemistry letters, Mar-22, Volume: 9, Issue:6	Synthesis, in vitro cytotoxicity and in vivo anti-inflammatory activity of long chain 3-amino-1,2-diols.
AID107202	Cytotoxicity was evaluated against melanoma M96 cell-line by MTT assay	1998	Bioorganic & medicinal chemistry letters, Jun-16, Volume: 8, Issue:12	Synthesis and in vitro cytotoxicity of lipophilic platinum(II) complexes.
AID100107	In vitro inhibitory activity against LL murine NSCLC cell line;	1999	Bioorganic & medicinal chemistry letters, Mar-22, Volume: 9, Issue:6	Synthesis, in vitro cytotoxicity and in vivo anti-inflammatory activity of long chain 3-amino-1,2-diols.
AID276968	Cytotoxicity against BALB/c mouse splenocytes at 10 ug/ml by MTT assay	2006	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23	Synthesis and evaluation of some lipidic aminoalcohols and diamines as immunomodulators.
AID184176	In vivo anti-inflammatory activity against carrageenan-induced paw edema assay in rats at dose 0.15 mM/kg	1999	Bioorganic & medicinal chemistry letters, Mar-22, Volume: 9, Issue:6	Synthesis, in vitro cytotoxicity and in vivo anti-inflammatory activity of long chain 3-amino-1,2-diols.
AID100266	In vitro for leishmanicidal activity against Leishmania donovani (PP75) at the concentration of 25 ug/mL.	2002	Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4	Leishmanicidal activity of some aliphatic diamines and amino-alcohols.
AID276966	Inhibition of concanavalin A-stimulated lymphoproliferation in BALB/c mouse splenocytes at 10 ug/ml by MTT assay	2006	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23	Synthesis and evaluation of some lipidic aminoalcohols and diamines as immunomodulators.
AID276967	Inhibition of concanavalin A-stimulated lymphoproliferation in BALB/c mouse splenocytes at 1 ug/ml by MTT assay	2006	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23	Synthesis and evaluation of some lipidic aminoalcohols and diamines as immunomodulators.
AID99850	In vitro for leishmanicidal activity against Leishmania amazonensis (PH8) at the concentration of 100 ug/mL.	2002	Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4	Leishmanicidal activity of some aliphatic diamines and amino-alcohols.
AID441082	Ratio of ethambutol MIC to compound MIC for Mycobacterium tuberculosis H37Rv ATCC 27294	2009	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19	Simple dihydrosphyngosine analogues with potent activity against MDR-Mycobacterium tuberculosis.
AID215103	In vitro inhibitory activity against human and neck squamous cell carcinoma UMSCC-22B cell line	1999	Bioorganic & medicinal chemistry letters, Mar-22, Volume: 9, Issue:6	Synthesis, in vitro cytotoxicity and in vivo anti-inflammatory activity of long chain 3-amino-1,2-diols.
AID276969	Cytotoxicity against BALB/c mouse splenocytes at 1 ug/ml by MTT assay	2006	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23	Synthesis and evaluation of some lipidic aminoalcohols and diamines as immunomodulators.
AID441084	Ratio of ethambutol MIC to compound MIC for Mycobacterium tuberculosis CIB99	2009	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19	Simple dihydrosphyngosine analogues with potent activity against MDR-Mycobacterium tuberculosis.
AID100009	In vitro for leishmanicidal activity against Leishmania brasiliensis (2903) at the concentration of 25 ug/mL.	2002	Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4	Leishmanicidal activity of some aliphatic diamines and amino-alcohols.
AID10178	In vitro inhibitory activity against human ovarian cancer A2780 cell line	1999	Bioorganic & medicinal chemistry letters, Mar-22, Volume: 9, Issue:6	Synthesis, in vitro cytotoxicity and in vivo anti-inflammatory activity of long chain 3-amino-1,2-diols.
AID99262	Cytotoxicity was evaluated against leukemia P388 cell-line by MTT assay	1998	Bioorganic & medicinal chemistry letters, Jun-16, Volume: 8, Issue:12	Synthesis and in vitro cytotoxicity of lipophilic platinum(II) complexes.
AID95295	Inhibitory concentration required for 50% apoptosis induction was evaluated using jurkat cells (T-lymphoma cells)	2002	Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18	Long-chain aminoalcohol and diamine derivatives induce apoptosis through a caspase-3 dependent pathway.
AID99996	In vitro for leishmanicidal activity against Leishmania brasiliensis (2903) at the concentration of 10 ug/mL.	2002	Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4	Leishmanicidal activity of some aliphatic diamines and amino-alcohols.
AID80665	In vitro inhibitory activity against H322 human NSCLC cell line	1999	Bioorganic & medicinal chemistry letters, Mar-22, Volume: 9, Issue:6	Synthesis, in vitro cytotoxicity and in vivo anti-inflammatory activity of long chain 3-amino-1,2-diols.
AID195108	Cytotoxicity was evaluated against renal E39 cell-line by MTT assay	1998	Bioorganic & medicinal chemistry letters, Jun-16, Volume: 8, Issue:12	Synthesis and in vitro cytotoxicity of lipophilic platinum(II) complexes.
AID276970	Increase in nitric oxide production in normal rat alveolar macrophages	2006	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23	Synthesis and evaluation of some lipidic aminoalcohols and diamines as immunomodulators.
AID100264	In vitro for leishmanicidal activity against Leishmania donovani (PP75) at the concentration of 100 ug/mL.	2002	Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4	Leishmanicidal activity of some aliphatic diamines and amino-alcohols.
AID100271	In vitro for leishmanicidal activity against Leishmania donovani (PP75) at the concentration of 50 ug/mL.	2002	Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4	Leishmanicidal activity of some aliphatic diamines and amino-alcohols.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (42.86)	18.2507
2000's	4 (57.14)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
ethambutol Ethambutol: An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863). ethambutol : An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.	2.05	1	ethanolamines; ethylenediamine derivative	antitubercular agent; environmental contaminant; xenobiotic
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	2.01	1	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
rifampin Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)	2.05	1	cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion	angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor

Condition	Relationship Strength	Studies
Anasarca [description not available]	2.4	2
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.4	2
Tuberculosis, Drug-Resistant [description not available]	2.05	1
Tuberculosis, Multidrug-Resistant Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.	2.05	1

1,2-hexadecanediamine

Description

Cross-References

Synonyms (10)

Bioassays (34)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.34

Study Types

1,2-hexadecanediamine

Description

Cross-References

Synonyms (10)

Bioassays (34)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.34

Study Types

Related Drugs (4)

Related Conditions (4)