1,2-dihexanoylglycerol profile

## 1,2-Dihexanoylglycerol: A Key Player in Fat Metabolism

1,2-dihexanoylglycerol (1,2-DiC6:0) is a **diacylglycerol (DAG)**, a type of lipid molecule that plays a crucial role in fat metabolism and cellular signaling. It is specifically composed of two **hexanoic acid** (caproic acid) molecules attached to a glycerol backbone.

Here's why it's important for research:

**1. Understanding Fat Metabolism:**

* **Intermediate in triglyceride synthesis:** 1,2-DiC6:0 is a crucial intermediate in the biosynthesis of triglycerides, the primary form of fat storage in the body. Understanding its role helps researchers explore pathways for controlling fat storage and preventing obesity.
* **Potential for drug development:** Exploring the enzymatic pathways involving 1,2-DiC6:0 could lead to the development of new drugs that target specific steps in fat metabolism, potentially impacting lipid disorders and obesity treatment.

**2. Signaling Pathways:**

* **Activator of protein kinase C (PKC):** 1,2-DiC6:0 is a potent activator of protein kinase C (PKC), a family of enzymes crucial for various cellular processes, including cell growth, differentiation, and survival. This signaling pathway is involved in insulin sensitivity, glucose metabolism, and inflammation.
* **Investigating PKC activation:** Researchers use 1,2-DiC6:0 to investigate the mechanisms of PKC activation and its role in different diseases. This knowledge helps develop targeted therapies for various conditions, including cancer and diabetes.

**3. Studying Lipid Droplet Dynamics:**

* **Lipase activity:** 1,2-DiC6:0 is a substrate for specific lipases, enzymes that break down triglycerides stored in lipid droplets. Studying its breakdown helps researchers understand lipid droplet dynamics and their role in energy metabolism.
* **Targeting lipid droplet formation:** The study of 1,2-DiC6:0 may reveal new ways to target lipid droplet formation and mobilization, impacting various metabolic diseases and conditions like fatty liver disease.

**Overall, 1,2-dihexanoylglycerol is an important molecule for research as it offers insights into fat metabolism, signaling pathways, and lipid droplet dynamics. Further investigation could lead to groundbreaking discoveries in the treatment of various metabolic diseases and conditions.**

1,2-dihexanoylglycerol: functions as bioregulator of protein kinase C in human platelets; RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	152222
CHEBI ID	177077
SCHEMBL ID	2195274
MeSH ID	M0129508

Synonym
CHEBI:177077
1,2-dicaproylglycerol
1,2-dimyristoyl-rac-glycerol, ~99%
1,2-dihexanoylglycerol
(2-hexanoyloxy-3-hydroxypropyl) hexanoate
33774-66-2
hexanoic acid, diester with 1,2,3-propanetriol
hexanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester
17598-91-3
(2-hexanoyloxy-3-hydroxy-propyl) hexanoate
SCHEMBL2195274
2-(hexanoyloxy)-1-(hydroxymethyl)ethyl hexanoate
DTXSID30938726
3-hydroxypropane-1,2-diyl dihexanoate
PD049809
1-(hexanoyloxy)-3-hydroxypropan-2-yl hexanoate

Class	Description
1,2-diglyceride
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (27.27)	18.7374
1990's	5 (45.45)	18.2507
2000's	3 (27.27)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
1,2-didecanoylglycerol 1,2-didecanoylglycerol: functions as bioregulator of protein kinase C in human platelets; RN given refers to cpd without isomeric designation	1.96	1	1,2-diglyceride; decanoate ester
1,2-dioctanoylglycerol 1,2-dioctanoylglycerol: functions as bioregulator of protein kinase C in human platelets	2.39	2
chelerythrine chelerythrine : A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.	2	1	benzophenanthridine alkaloid; organic cation	antibacterial agent; antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor
r 59022 R 59022: diacylglycerol kinase inhibitor; structure given in first source; platelet activator factor antagonist	2.39	2	diarylmethane
erythrosine Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.	1.97	1
adenosine diphosphate Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.	1.98	1	adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	fundamental metabolite; human metabolite
1,2-dipalmitoylphosphatidylcholine 1,2-Dipalmitoylphosphatidylcholine: Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	2	1
thiazoles [no description available]	2.39	2	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
cadmium Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.	1.96	1	cadmium molecular entity; zinc group element atom
cadmium chloride Cadmium Chloride: A cadmium halide in the form of colorless crystals, soluble in water, methanol, and ethanol. It is used in photography, in dyeing, and calico printing, and as a solution to precipitate sulfides. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed). cadmium dichloride : A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.	1.96	1	cadmium coordination entity
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	1.97	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
phorbol 12,13-dibutyrate Phorbol 12,13-Dibutyrate: A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.	1.97	1	butyrate ester; phorbol ester; tertiary alpha-hydroxy ketone
methacycline [no description available]	2.02	1	1,2-diglyceride
1-hexadecyl-2-acetyl-glycero-3-phosphocholine Platelet Activating Factor: A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.. 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine : A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.	1.99	1	2-acetyl-1-alkyl-sn-glycero-3-phosphocholine	antihypertensive agent; beta-adrenergic antagonist; bronchoconstrictor agent; hematologic agent; vasodilator agent
1,2-dimyristoylphosphatidylethanolamine [no description available]	2	1
1,2-oleoylphosphatidylcholine 1,2-oleoylphosphatidylcholine: RN given refers to (Z,Z)-isomer. dioleoyl phosphatidylcholine : A phosphatidylcholine in which the phosphatidyl acyl groups are both oleoyl.	2.02	1	phosphatidylcholine(1+)
dimyristoylphosphatidylcholine 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine : A 1,2-diacyl-sn-glycero-3-phosphocholine where the two phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).. dimyristoyl phosphatidylcholine : A phosphatidylcholine where the phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).	2	1	1,2-diacyl-sn-glycero-3-phosphocholine; phosphatidylcholine 28:0; tetradecanoate ester	antigen; mouse metabolite
1-oleoyl-2-acetylglycerol [no description available]	2.89	4	1,2-diglyceride
1-stearoyl-2-linoleoyl-sn-glycerol 1-stearoyl-2-linoleoyl-sn-glycerol : A 1,2-diacyl-sn-glycerol in which the acyl groups at positions 1 and 2 are specified as stearoyl and linoleoyl respectively.	2.02	1	1,2-diacyl-sn-glycerol; diacylglycerol 36:2	mouse metabolite
staurosporine staurosporinium : Conjugate acid of staurosporine.	2.38	2	ammonium ion derivative
ucn 1028 c calphostin C: structure given in first source; isolated from Cladosporium cladosporioides	2	1
glucagon Glucagon: A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511). glucagon : A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.	1.97	1	peptide hormone
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	2.02	1	1,2-diacyl-sn-glycero-3-phosphocholine
okadaic acid Okadaic Acid: A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. It is produced by DINOFLAGELLATES and causes diarrhetic SHELLFISH POISONING.. okadaic acid : A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.	2.38	2	ketal
2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein [no description available]	1.97	1
pyrimidinones Pyrimidinones: Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O.	2.39	2

1,2-dihexanoylglycerol

Description

Cross-References

Synonyms (16)

Drug Classes (1)

Research

Studies (11)

Study Types