Compounds > 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine
Page last updated: 2024-11-12

1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine: a chloroethylating agent that alkylates and cross-links DNA; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10198873
CHEMBL ID74583
SCHEMBL ID259901
MeSH IDM0524230

Synonyms (19)

Synonym
vpn-4090ce
CHEMBL74583
127792-84-1
methanesulfonic acid, 2-(2-chloroethyl)-2-(methylsulfonyl)hydrazide
unii-6ze344986h
6ze344986h ,
90ce
2-(2-chloroethyl)-2-(methylsulfonyl)hydrazide methanesulfonic acid
vpn-4090ce [mi]
vnp-4090ce [mi]
laromustine metabolite (vnp-4090ce)
1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine
vnp-4090ce
SCHEMBL259901
QVKFHBWVOPWLGX-UHFFFAOYSA-N
DTXSID70436695
n'-(2-chloroethyl)-n'-methylsulfonylmethanesulfonohydrazide
Q27265777
n'-(2-chloroethyl)-n'-methanesulfonylmethanesulfonohydrazide
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID733206Half life in 1 mM potassium phosphate buffer at pH 7.4 at 50 uM by spectrophotometric analysis2013Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6
Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells.
AID97202Evaluated for average percent change in body weight from onset to termination of therapy against L1210 Leukemia cells in mice after 15 mg/kg dose administration.1990Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
Synthesis and evaluation of 1,2,2-tris(sulfonyl)hydrazines as antineoplastic and trypanocidal agents.
AID733204Binding affinity to mouse L1210 cell DNA assessed as DNA cross-linking activity at 10 to 50 uM using H33258 dye by rapid DNA renaturation assay2013Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6
Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells.
AID25380Half life measured at 30 degree Celsius relative to 37 degree Centigrade1994Journal of medicinal chemistry, Sep-02, Volume: 37, Issue:18
Studies on the mechanism of decomposition and structural factors affecting the aqueous stability of 1,2-bis(sulfonyl)-1-alkylhydrazines.
AID100020Average survival time of treated group / control group x(100) was determined.1990Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
Synthesis and evaluation of 1,2,2-tris(sulfonyl)hydrazines as antineoplastic and trypanocidal agents.
AID99887Percentage of mice survived after 60 days of treatment with the compound was determined.1990Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
Synthesis and evaluation of 1,2,2-tris(sulfonyl)hydrazines as antineoplastic and trypanocidal agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (25.00)18.2507
2000's1 (12.50)29.6817
2010's5 (62.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.97

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.97 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index5.17 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.97)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		2.110amino-acid anion
cytosine
[no description available]		2.0410aminopyrimidine;
pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ethane
Ethane: A two carbon alkane with the formula H3C-CH3.. ethane : An alkane comprising of two carbon atoms.		2.0410alkane;
gas molecular entity		plant metabolite;
refrigerant
hydrazine
diamine : Any polyamine that contains two amino groups.		3.1950azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
methyl isocyanate
methyl isocyanate: structure. methyl isocyanate : The isocyanate that is methane modified by a single isocyanato substituent.		2.110isocyanatesallergen;
apoptosis inducer
cyanates
Cyanates: Organic salts of cyanic acid containing the -OCN radical.. cyanates : Salts and esters of cyanic acid, HOC#N; compounds carrying the cyanate functional group -O-C#N.. isocyanates : Organonitrogen compounds that are derivatives of isocyanic acid; compounds containing the isocyanate functional group -N=C=O (as opposed to the cyanate group, -O-C#N).		2.5320
1,2-bis(methylsulfonyl)-1-methylhydrazine
[no description available]		2.6930
laromustine
laromustine: has antineoplastic activity		3.3460
guanine
[no description available]		2.47202-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia L 1210
[description not available]		01.9710
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		01.9710
Sarcoma 180
An experimental sarcoma of mice.		01.9710
African Sleeping Sickness
[description not available]		01.9710
Trypanosomiasis, African
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.		01.9710
Leucocythaemia
[description not available]		02.4920
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)		02.4920
Benign Neoplasms
[description not available]		02.110
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.110