Compounds > 1,2-benzenedicarbonitrile
Page last updated: 2024-12-05

1,2-benzenedicarbonitrile

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1,2-Benzenedicarbonitrile, also known as phthalonitrile, is a white crystalline solid that is an important precursor to phthalocyanine pigments. It is synthesized by the dehydration of phthalimide using a variety of reagents, including phosphorus pentoxide, acetic anhydride, and trifluoroacetic anhydride. The compound has been found to exhibit high thermal stability and resistance to hydrolysis. Due to its properties, it has been explored as a potential building block for advanced materials, particularly for use in high-performance polymers and organic electronic devices. The compound is also being researched for its potential applications in catalysis, due to its ability to coordinate metals. '

Cross-References

ID SourceID
PubMed CID7042
CHEMBL ID3185350
SCHEMBL ID57480
MeSH IDM0136140

Synonyms (59)

Synonym
AC-14597
o-dicyanobenzene
1,2-dicyanobenzene
o-cyanobenzonitrile
o-pdn
nsc-17562
phthalodinitrile
o-phthalodinitrile
phthalonitrile
1,2-benzodinitrile
1,2-benzenedicarbonitrile
wln: ncr bcn
o-benzenedicarbonitrile
phthalic acid dinitrile
nsc17562
91-15-6
usaf nd-09
ccris 8898
hsdb 5273
ftalodinitril [czech]
1,2-benzendikarbonitril [czech]
nsc 17562
ortho-dicyanobenzene
ai3-00049
ftalonitril [czech]
o-benzenedinitrile
einecs 202-044-8
1,2-dicyanobenzene, 98%
P0404
STK802328
benzene-1,2-dicarbonitrile
AKOS000120698
NCGC00248893-01
tox21_200999
dtxsid8029604 ,
cas-91-15-6
dtxcid709604
NCGC00258552-01
ftalonitril
ec 202-044-8
unii-978627yaju
1,2-benzendikarbonitril
ftalodinitril
978627yaju ,
FT-0606389
1,2-benzenedicarbonitrile [hsdb]
1,2-bis(cyano)benzene
SCHEMBL57480
o-phthalonitrile
W-100316
CS-W016553
CHEMBL3185350
mfcd00001771
F0001-2216
Q408783
AMY17974
EN300-21053
D70390
Z104486876
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
pregnane X nuclear receptorHomo sapiens (human)Potency53.18460.005428.02631,258.9301AID1346982
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency19.03360.023723.228263.5986AID743222
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
nickel
Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.		2.0510metal allergen;
nickel group element atom		epitope;
micronutrient
cyanides
Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.. cyanides : Salts and C-organyl derivatives of hydrogen cyanide, HC#N.. isocyanide : The isomer HN(+)#C(-) of hydrocyanic acid, HC#N, and its hydrocarbyl derivatives RNC (RN(+)#C(-)).. cyanide : A pseudohalide anion that is the conjugate base of hydrogen cyanide.		1.9710pseudohalide anionEC 1.9.3.1 (cytochrome c oxidase) inhibitor
acrylamide
[no description available]		1.9610acrylamides;
N-acylammonia;
primary carboxamide		alkylating agent;
carcinogenic agent;
Maillard reaction product;
mutagen;
neurotoxin
benzonitrile
benzonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a phenyl group.		1.9910benzenes;
nitrile
1,4-dicyanobenzene
1,4-dicyanobenzene: occupational marker compound		1.9710
europium
Europium: An element of the rare earth family of metals. It has the atomic symbol Eu, atomic number 63, and atomic weight 152. Europium is used in the form of its salts as coatings for cathode ray tubes and in the form of its organic derivatives as shift reagents in NMR spectroscopy.		2.1110f-block element atom;
lanthanoid atom
phthalocyanine
phthalocyanine : A tetrapyrrole fundamental parent that consists of four isoindole-type units, with the connecting carbon atoms in the macrocycle replaced by nitrogen.		2.0510phthalocyanines;
tetrapyrrole fundamental parent
ConditionIndicatedRelationship StrengthStudiesTrials