1,2-5,6-di-o-isopropylidene-d-glucofuranose

Description

## 1,2:5,6-Di-O-isopropylidene-D-glucofuranose: A Key Building Block in Organic Synthesis

**1,2:5,6-Di-O-isopropylidene-D-glucofuranose** is a derivative of D-glucose, a common sugar found in nature. It's a protected form of glucose, meaning that its reactive hydroxyl groups are masked by isopropylidene groups. This makes it a valuable starting material for organic synthesis.

**Here's why it's important for research:**

1. **Protection of Hydroxyl Groups:** The isopropylidene groups protect the hydroxyl groups of glucose, preventing them from participating in unwanted reactions. This allows for selective manipulation of other functional groups within the molecule.
2. **Increased Reactivity:** The protected form of glucose becomes more reactive in certain reactions. This is because the isopropylidene groups change the electronic environment around the remaining free hydroxyl groups.
3. **Versatility:** 1,2:5,6-Di-O-isopropylidene-D-glucofuranose can be used to synthesize a wide variety of complex molecules, including:
- **Glycosides:** These are compounds with a sugar molecule attached to another molecule.
- **Glycoconjugates:** These are complex molecules containing sugars linked to other biological molecules like proteins and lipids.
- **Oligosaccharides:** These are short chains of sugars.
4. **Model System:** It can serve as a model system for studying the reactivity of sugars and the synthesis of complex carbohydrate structures.
5. **Drug Discovery:** It's used in the development of new drugs, particularly those targeting carbohydrate-binding proteins.

**Here are some examples of its use in research:**

* **Synthesis of Glycosides:** It can be used to synthesize glycosides that are relevant to biological systems, such as those involved in cell recognition and signaling.
* **Development of Antiviral Agents:** Researchers are using it to develop new antiviral agents that block the interaction of viruses with their host cells.
* **Study of Protein-Carbohydrate Interactions:** It can be used to study how proteins interact with carbohydrates, which is essential for understanding the role of carbohydrates in biological processes.

**Overall, 1,2:5,6-Di-O-isopropylidene-D-glucofuranose is a valuable reagent for organic synthesis and has applications in a variety of fields, including medicine, biotechnology, and materials science.**

1,2-5,6-di-O-isopropylidene-D-glucofuranose: used in determination of blood glucose; RN given refers to parent cpd; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]