Compounds > 1,2,3,4-tetrahydrocarbazole
Page last updated: 2024-11-05

1,2,3,4-tetrahydrocarbazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,2,3,4-tetrahydrocarbazole: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID13664
CHEMBL ID1911317
SCHEMBL ID104598
MeSH IDM0364938

Synonyms (62)

Synonym
unii-8zlk0tsx93
5-20-07-00468 (beilstein handbook reference)
8zlk0tsx93 ,
BB 0242805
carbazole, 1,2,3,4-tetrahydro-
brn 0133771
5,6,7,8-tetrahydrocarbazole
1,2,3,4-tetrahydrocarbazole
1h-indole, 2,3-(1,4-butanediyl)-
einecs 213-385-7
carbazole, 5,6,7,8-tetrahydro-
nsc 17329
5,6,7,8-tetrahydro-9h-carbazole
AB-337/25021010
nsc17329
5,7,8-tetrahydrocarbazole
1h-carbazole,3,4,9-tetrahydro-
2,3-tetramethyleneindole
wln: t b656 hm&&tj
carbazole,6,7,8-tetrahydro-
1,3,4-tetrahydrocarbazole
1h-indole,3-(1,4-butanediyl)-
942-01-8
nsc-17329
carbazole,2,3,4-tetrahydro-
2,3-tetramethylene-1h-indole
2,3,4,9-tetrahydro-1h-carbazole
1h-carbazole, 2,3,4,9-tetrahydro-
carbazole,1,2,3,4-tetrahydro
inchi=1/c12h13n/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11/h1,3,5,7,13h,2,4,6,8h
EU-0070508
1,2,3,4-tetrahydrocarbazole, 99%
STK394140
AC-11745
AKOS000271191
T1006
HMS1651H10
A844868
NCGC00186306-01
F1918-0039
CHEMBL1911317
FT-0606195
SCHEMBL104598
1,2,3,4-tetrahydro-9h-carbazole
1,2,3,4,-tetrahydrocarbazole
tetrahydrocarbazole
tetrahydocarbazole
2,3,4,9-tetrahydro-1h-carbazole #
W-100206
2,3,4,9-tetrahydro-9h-carbazole
1231158-33-0
F0832-0099
DTXSID00240969
CS-W004910
mfcd00004959
SR-01000424125-1
sr-01000424125
SY033427
1.2.3.4-tetrahydrocarbazole
Q27271250
BAA77586
EN300-82532
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
67.9K proteinVaccinia virusPotency22.38720.00018.4406100.0000AID720579
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID626881Antiprion activity in human transmissible spongiform encephalopathies agent Fukuoka-1 prion infected mouse GT1-7 cells assessed as inhibition of proteinase K-resistant PrPres accumulation at 10 mM after 3 days by Western blotting analysis2011European journal of medicinal chemistry, Nov, Volume: 46, Issue:11
Synthesis of 9-substituted 2,3,4,9-tetrahydro-1H-carbazole derivatives and evaluation of their anti-prion activity in TSE-infected cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (22)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (36.36)29.6817
2010's12 (54.55)24.3611
2020's2 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 40.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index40.72 (24.57)
Research Supply Index3.14 (2.92)
Research Growth Index5.51 (4.65)
Search Engine Demand Index54.12 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (40.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.55%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other21 (95.45%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
indole
[no description available]		7.0610indole;
polycyclic heteroarene		Escherichia coli metabolite
dichlorodicyanobenzoquinone
dichlorodicyanobenzoquinone: request from searcher		2.0610
diphenyl
diphenyl: RN given refers to unlabeled cpd; structure		2.0510aromatic fungicide;
benzenes;
biphenyls		antifungal agrochemical;
antimicrobial food preservative
anisole
anisole : A monomethoxybenzene that is benzene substituted by a methoxy group.		2.0310monomethoxybenzeneplant metabolite
quinazolines
Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.		2.1310azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
cyclopentane
Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.		2.4520cycloalkane;
cyclopentanes;
volatile organic compound		non-polar solvent
chrysoidine
chrysoidine: RN given refers to parent cpd; structure		2.0610
n-methylcarbazole
N-methylcarbazole: RN given refers to cpd with methyl group in position 9		2.0510
iridium
Iridium: A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.		2.0710cobalt group element atom;
platinum group metal atom
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.0410metal allergen;
nickel group element atom;
platinum group metal atom
alkenes
[no description available]		2.0510
uleine
uleine: from the bark of Plumeria lancifolia; structure in first source		7.0610
betadex
beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.		210cyclodextrin
mannich bases
Mannich Bases: Ketonic amines prepared from the condensation of a ketone with formaldehyde and ammonia or a primary or secondary amine. A Mannich base can act as the equivalent of an alpha,beta unsaturated ketone in synthesis or can be reduced to form physiologically active amino alcohols.		7.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610
Dementias, Transmissible
[description not available]		02.0610
Benign Neoplasms
[description not available]		02.1510
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.1510