Page last updated: 2024-12-05

1,2,3,4-butanetetracarboxylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

## 1,2,3,4-Butanetetracarboxylic Acid: A Versatile Building Block

1,2,3,4-Butanetetracarboxylic acid (BTCA) is a tetracarboxylic acid with the formula C8H8O8. It's a white solid with a high melting point.

**Here's why it's important in research:**

**1. Synthesis of Novel Materials:**

* **Polymers:** BTCA is a valuable monomer for synthesizing various polymers. It acts as a crosslinking agent, improving the mechanical properties, thermal stability, and flame retardancy of polymers.
* **Metal-Organic Frameworks (MOFs):** The multiple carboxyl groups in BTCA allow it to coordinate with metal ions, forming porous structures with high surface areas and tunable properties. These MOFs have applications in gas storage, separation, and catalysis.
* **Electrodes:** BTCA-based materials exhibit good electrochemical properties, making them promising candidates for use in batteries and fuel cells.

**2. Biological Applications:**

* **Drug Delivery:** BTCA's chemical structure can be modified to create drug carriers with specific targeting capabilities.
* **Antibacterial Agents:** Certain BTCA derivatives show antibacterial activity, potentially leading to new antibiotic therapies.

**3. Other Applications:**

* **Flame Retardants:** BTCA's structure allows it to act as a flame retardant in polymers and other materials.
* **Surfactants:** Derivatives of BTCA can be used as surfactants in detergents and cleaning agents.

**Research Significance:**

The versatility of BTCA makes it an attractive building block for various applications. Researchers are actively exploring its potential in developing new materials, pharmaceuticals, and other technologies.

**Examples of Recent Research:**

* **Synthesis of a novel BTCA-based MOF for efficient CO2 capture:** [link to research article]
* **Development of BTCA-based polymers with improved flame retardancy:** [link to research article]
* **Investigation of BTCA derivatives as antibacterial agents:** [link to research article]

Overall, 1,2,3,4-butanetetracarboxylic acid continues to be a valuable research subject due to its unique properties and potential applications in various fields.

1,2,3,4-butanetetracarboxylic acid: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID15560
CHEMBL ID1574612
SCHEMBL ID22151
MeSH IDM0501848

Synonyms (39)

Synonym
c8h10o8
AKOS015837629
1703-58-8
1,3,4-butanetetracarboxylic acid
nsc21371
NCGC00090718-01
1,2,3,4-butanetetracarboxylic acid (8ci) (9ci)
1,2,3,4-butanetetracarboxylic acid, 99%
NCGC00090718-02
butane-1,2,3,4-tetracarboxylic acid
1,2,3,4-butanetetracarboxylic acid
ggauuqhscnmcau-uhfffaoysa-
inchi=1/c8h10o8/c9-5(10)1-3(7(13)14)4(8(15)16)2-6(11)12/h3-4h,1-2h2,(h,9,10)(h,11,12)(h,13,14)(h,15,16)
A811192
NCGC00090718-03
cas-1703-58-8
dtxsid6024670 ,
tox21_303236
NCGC00257149-01
dtxcid704670
NCGC00258823-01
tox21_201271
FT-0628238
FT-0606181
MLS004491893
smr001599924
1,2,3,4-butane tetracarboxylic acid
SCHEMBL22151
CHEMBL1574612
W-107885
1,2,3,4-butanetetracarboxylic acid #
mfcd00002722
CS-0015793
ethyl-3-chlorophenylacetate
AS-14355
AMY6185
H11745
butane-1,2,3,4-tetracarboxylicacid
EN300-96134
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (10)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency0.56230.003245.467312,589.2998AID2517
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency50.11870.004023.8416100.0000AID485290
RAR-related orphan receptor gammaMus musculus (house mouse)Potency68.58960.006038.004119,952.5996AID1159521
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency0.61020.001530.607315,848.9004AID1224841; AID1224842
estrogen nuclear receptor alphaHomo sapiens (human)Potency60.59790.000229.305416,493.5996AID743069
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency0.00350.001024.504861.6448AID743215
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency43.64650.023723.228263.5986AID743222
thyroid stimulating hormone receptorHomo sapiens (human)Potency0.26830.001628.015177.1139AID1224843
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency67.40560.000323.4451159.6830AID743065
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency27.30600.000627.21521,122.0200AID651741
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's5 (50.00)24.3611
2020's3 (30.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 36.82

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index36.82 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.99 (4.65)
Search Engine Demand Index44.62 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (36.82)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]