1,2,3,4-butanetetracarboxylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

## 1,2,3,4-Butanetetracarboxylic Acid: A Versatile Building Block

1,2,3,4-Butanetetracarboxylic acid (BTCA) is a tetracarboxylic acid with the formula C8H8O8. It's a white solid with a high melting point.

**Here's why it's important in research:**

**1. Synthesis of Novel Materials:**

* **Polymers:** BTCA is a valuable monomer for synthesizing various polymers. It acts as a crosslinking agent, improving the mechanical properties, thermal stability, and flame retardancy of polymers.
* **Metal-Organic Frameworks (MOFs):** The multiple carboxyl groups in BTCA allow it to coordinate with metal ions, forming porous structures with high surface areas and tunable properties. These MOFs have applications in gas storage, separation, and catalysis.
* **Electrodes:** BTCA-based materials exhibit good electrochemical properties, making them promising candidates for use in batteries and fuel cells.

**2. Biological Applications:**

* **Drug Delivery:** BTCA's chemical structure can be modified to create drug carriers with specific targeting capabilities.
* **Antibacterial Agents:** Certain BTCA derivatives show antibacterial activity, potentially leading to new antibiotic therapies.

**3. Other Applications:**

* **Flame Retardants:** BTCA's structure allows it to act as a flame retardant in polymers and other materials.
* **Surfactants:** Derivatives of BTCA can be used as surfactants in detergents and cleaning agents.

**Research Significance:**

The versatility of BTCA makes it an attractive building block for various applications. Researchers are actively exploring its potential in developing new materials, pharmaceuticals, and other technologies.

**Examples of Recent Research:**

* **Synthesis of a novel BTCA-based MOF for efficient CO2 capture:** [link to research article]
* **Development of BTCA-based polymers with improved flame retardancy:** [link to research article]
* **Investigation of BTCA derivatives as antibacterial agents:** [link to research article]

Overall, 1,2,3,4-butanetetracarboxylic acid continues to be a valuable research subject due to its unique properties and potential applications in various fields.

1,2,3,4-butanetetracarboxylic acid: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	15560
CHEMBL ID	1574612
SCHEMBL ID	22151
MeSH ID	M0501848

Synonyms (39)

Synonym
c8h10o8
AKOS015837629
1703-58-8
1,3,4-butanetetracarboxylic acid
nsc21371
NCGC00090718-01
1,2,3,4-butanetetracarboxylic acid (8ci) (9ci)
1,2,3,4-butanetetracarboxylic acid, 99%
NCGC00090718-02
butane-1,2,3,4-tetracarboxylic acid
1,2,3,4-butanetetracarboxylic acid
ggauuqhscnmcau-uhfffaoysa-
inchi=1/c8h10o8/c9-5(10)1-3(7(13)14)4(8(15)16)2-6(11)12/h3-4h,1-2h2,(h,9,10)(h,11,12)(h,13,14)(h,15,16)
A811192
NCGC00090718-03
cas-1703-58-8
dtxsid6024670 ,
tox21_303236
NCGC00257149-01
dtxcid704670
NCGC00258823-01
tox21_201271
FT-0628238
FT-0606181
MLS004491893
smr001599924
1,2,3,4-butane tetracarboxylic acid
SCHEMBL22151
CHEMBL1574612
W-107885
1,2,3,4-butanetetracarboxylic acid #
mfcd00002722
CS-0015793
ethyl-3-chlorophenylacetate
AS-14355
AMY6185
H11745
butane-1,2,3,4-tetracarboxylicacid
EN300-96134

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (10)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	0.5623	0.0032	45.4673	12,589.2998	AID2517
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	50.1187	0.0040	23.8416	100.0000	AID485290
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	68.5896	0.0060	38.0041	19,952.5996	AID1159521
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	0.6102	0.0015	30.6073	15,848.9004	AID1224841; AID1224842
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	60.5979	0.0002	29.3054	16,493.5996	AID743069
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	0.0035	0.0010	24.5048	61.6448	AID743215
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	43.6465	0.0237	23.2282	63.5986	AID743222
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	0.2683	0.0016	28.0151	77.1139	AID1224843
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	67.4056	0.0003	23.4451	159.6830	AID743065
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	27.3060	0.0006	27.2152	1,122.0200	AID651741
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (20.00)	29.6817
2010's	5 (50.00)	24.3611
2020's	3 (30.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 36.82

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	36.82 (24.57)
Research Supply Index	2.48 (2.92)
Research Growth Index	4.99 (4.65)
Search Engine Demand Index	44.62 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (36.82)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
cuminaldehyde cuminaldehyde : A member of the class of benzaldehydes that is benzaldehyde substituted by an isopropyl group at position 4. It is a component of essential oils from Cumin and exhibits insecticidal activities.	2.31	1	benzaldehydes	insecticide; plant metabolite; volatile oil component
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	2.25	1	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
nickel Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.	2.03	1	metal allergen; nickel group element atom	epitope; micronutrient
glutaral Glutaral: One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.. glutaraldehyde : A dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.	2.17	1	dialdehyde	cross-linking reagent; disinfectant; fixative
phenylethyl alcohol Phenylethyl Alcohol: An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.. 2-phenylethanol : A primary alcohol that is ethanol substituted by a phenyl group at position 2.	2.31	1	benzenes; primary alcohol	Aspergillus metabolite; fragrance; plant growth retardant; plant metabolite; Saccharomyces cerevisiae metabolite
dichloroacetic acid [no description available]	2.11	1	monocarboxylic acid; organochlorine compound	astringent; marine metabolite
acrolein [no description available]	2.31	1	enal	herbicide; human xenobiotic metabolite; toxin
carvacrol carvacrol : A phenol that is a natural monoterpene derivative of cymene. An inhibitor of bacterial growth, it is used as a food additive. Potent activator of the human ion channels transient receptor potential V3 (TRPV3) and A1 (TRPA1).	2.31	1	botanical anti-fungal agent; p-menthane monoterpenoid; phenols	agrochemical; antimicrobial agent; flavouring agent; TRPA1 channel agonist; volatile oil component
dioxouranium(vi) [no description available]	2.04	1	uranium oxide
manganese Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.	2.03	1	elemental manganese; manganese group element atom	Escherichia coli metabolite; micronutrient
silver Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.	2.11	1	copper group element atom; elemental silver	Escherichia coli metabolite
uranium Uranium: A radioactive element of the actinide series of metals. It has an atomic symbol U, atomic number 92, and atomic weight 238.03. U-235 is used as the fissionable fuel in nuclear weapons and as fuel in nuclear power reactors.	2.04	1	actinoid atom; f-block element atom; monoatomic uranium
3,4-dihydroxyphenylethanol 3,4-dihydroxyphenylethanol: serotonin metabolite; structure	2.31	1	catechols; primary alcohol	antineoplastic agent; antioxidant; metabolite
cobalt Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.	2.03	1	cobalt group element atom; metal allergen	micronutrient
betadex beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.	2.31	1	cyclodextrin
cinnamaldehyde 3-phenylprop-2-enal : A member of the class of cinnamaldehydes that is prop-2-enal in which a hydrogen at position 3 has been replaced by a phenyl group. The configuration of the double bond is not specified; the name "cinnamaldehyde" is widely used to refer to the E (trans) isomer.. (E)-cinnamaldehyde : The E (trans) stereoisomer of cinnamaldehyde, the parent of the class of cinnamaldehydes.	2.31	1	3-phenylprop-2-enal; cinnamaldehydes	antifungal agent; EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor; flavouring agent; hypoglycemic agent; plant metabolite; sensitiser; vasodilator agent
lead Lead: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.	2.25	1	carbon group element atom; elemental lead; metal atom	neurotoxin
cellulose DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.	3.58	7	glycoside
sodium hypophosphite sodium hypophosphite: RN given refers to phosphinic acid, Na salt; structure	2.11	1
muramidase Muramidase: A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.	2.21	1

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