Page last updated: 2024-12-05

1,1-dichloropropene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

## 1,1-Dichloropropene: A Versatile Chemical with Research Potential

**1,1-Dichloropropene** is a colorless, flammable liquid with a pungent odor. It's an organic compound with the chemical formula CH2=CCl2CH3. Its importance lies in its **versatility** as a chemical building block and its potential applications in various research areas.

**Key Characteristics:**

* **Reactivity:** 1,1-Dichloropropene is highly reactive, participating in various chemical reactions including **polymerization**, **chlorination**, and **hydrochlorination**.
* **Versatile Applications:** This reactivity makes it a valuable starting material for synthesizing different organic compounds, including polymers, pesticides, and pharmaceuticals.
* **Presence in Environmental Samples:** It's a **common contaminant** in soil and groundwater, making its study crucial for environmental research.
* **Biological Activity:** Studies suggest 1,1-Dichloropropene exhibits **biological activity** against certain organisms, potentially leading to applications in agriculture and medicine.

**Research Importance:**

* **Synthesis of New Materials:** The reactivity of 1,1-Dichloropropene allows researchers to create new polymers with unique properties for various applications like construction materials, adhesives, and coatings.
* **Environmental Remediation:** Understanding its environmental fate and transport is crucial for developing strategies to remediate contaminated sites and protect water resources.
* **Pesticide Development:** Its biological activity has sparked interest in developing new pesticides to control pests and diseases in agriculture.
* **Pharmaceutical Research:** Studies investigating its potential as a therapeutic agent for different diseases are ongoing.

**Overall, 1,1-Dichloropropene is a compound with significant potential in various research areas, contributing to the development of new materials, improving environmental protection, and advancing agricultural and medical fields.**

**Note:** It's important to handle 1,1-Dichloropropene with caution due to its potential toxicity and environmental impact. It's crucial to follow safety guidelines and regulations while working with this compound.

1,1-dichloropropene: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11245
CHEMBL ID1595845
SCHEMBL ID119766
MeSH IDM0484650

Synonyms (34)

Synonym
unii-5c5688865r
5c5688865r ,
1-propene,1-dichloro-
563-58-6
1,1-dichloro-1-propene
1,1-dichloropropylene
nsc6201
1,1-dichloropropene
propene,1-dichloro-
nsc-6201
propene, 1,1-dichloro-
1-propene, 1,1-dichloro-
einecs 209-253-3
ccris 9037
nsc 6201
brn 1734809
NCGC00091506-01
inchi=1/c3h4cl2/c1-2-3(4)5/h2h,1h
1,1-dichloroprop-1-ene
NCGC00091506-02
tox21_200331
dtxsid1029910 ,
NCGC00257885-01
dtxcid009910
cas-563-58-6
AKOS006228585
26952-23-8
FT-0606098
CHEMBL1595845
dichloropropene, 1,1-
SCHEMBL119766
1,1-dichloropropene, certified reference material, 5000 mug/ml in methanol
1,1-dichloro-prop-1-ene
Q24755666
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency56.23410.004023.8416100.0000AID485290
thyroid stimulating hormone receptorHomo sapiens (human)Potency39.81070.001318.074339.8107AID926; AID938
pregnane X nuclear receptorHomo sapiens (human)Potency53.48690.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency11.74960.000229.305416,493.5996AID743075; AID743077
activating transcription factor 6Homo sapiens (human)Potency42.84150.143427.612159.8106AID1159516
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1101932Insecticidal activity against Rhyzopertha dominica after 24 hr2002Journal of agricultural and food chemistry, Sep-25, Volume: 50, Issue:20
QSAR evaluation of cyanohydrins' fumigation toxicity to house fly (Musca domestica) and lesser grain borer (Rhyzopertha dominica).
AID1101931Insecticidal activity against Musca domestica (house fly) after 24 hr2002Journal of agricultural and food chemistry, Sep-25, Volume: 50, Issue:20
QSAR evaluation of cyanohydrins' fumigation toxicity to house fly (Musca domestica) and lesser grain borer (Rhyzopertha dominica).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 41.93

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index41.93 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index55.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (41.93)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]