Page last updated: 2024-12-07

1,1'-oxalyldiimidazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,1'-Oxalyldiimidazole is a white, crystalline solid. It is a versatile reagent used in organic synthesis. Its importance lies in its ability to activate carboxylic acids for various reactions, including amidation, esterification, and peptide coupling. It is synthesized by reacting imidazole with oxalyl chloride in the presence of a base like triethylamine. The resulting compound is highly reactive and is widely used in research due to its high efficiency in activating carboxylic acids.

1,1'-oxalyldiimidazole: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID100439
SCHEMBL ID618874
MeSH IDM0553119

Synonyms (31)

Synonym
1,2-di(1h-imidazol-1-yl)ethane-1,2-dione
1h-imidazole, 1,1'-(1,2-dioxo-1,2-ethanediyl)bis-
AKOS015837676
18637-83-7
nsc299886
nsc-299886
1,1'-oxalyldiimidazole, technical grade
1,2-di(imidazol-1-yl)ethane-1,2-dione
1,1'-oxalyldiimidazole
O0200
oxalic acid diimidazolide
A813030
1-[1h-imidazol-1-yl(oxo)acetyl]-1h-imidazole
nsc 299886
FT-0606159
SCHEMBL618874
1,1'-oxalyl-diimidazol
ONRNRVLJHFFBJG-UHFFFAOYSA-N
1,1'-(1,2-dioxo-1,2-ethanediyl)bis-1h-imidazole
1,2-di-(1h-imidazol-1-yl)ethane-1,2-dione
DTXSID20171887
mfcd00043067
J-011961
1,1-oxalyldiimidazole
F14979
CS-0204873
AS-79145
1,1/'-oxalyldiimidazole
bis(1h-imidazol-1-yl)ethane-1,2-dione
1,2-di(1-imidazolyl)ethane-1,2-dione
SY052195
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.13 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index5.33 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]