Compounds > 1,1'-oxalyldiimidazole
Page last updated: 2024-12-07

1,1'-oxalyldiimidazole

Description

1,1'-Oxalyldiimidazole is a white, crystalline solid. It is a versatile reagent used in organic synthesis. Its importance lies in its ability to activate carboxylic acids for various reactions, including amidation, esterification, and peptide coupling. It is synthesized by reacting imidazole with oxalyl chloride in the presence of a base like triethylamine. The resulting compound is highly reactive and is widely used in research due to its high efficiency in activating carboxylic acids.

1,1'-oxalyldiimidazole: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID100439
SCHEMBL ID618874
MeSH IDM0553119

Synonyms (31)

Synonym
1,2-di(1h-imidazol-1-yl)ethane-1,2-dione
1h-imidazole, 1,1'-(1,2-dioxo-1,2-ethanediyl)bis-
AKOS015837676
18637-83-7
nsc299886
nsc-299886
1,1'-oxalyldiimidazole, technical grade
1,2-di(imidazol-1-yl)ethane-1,2-dione
1,1'-oxalyldiimidazole
O0200
oxalic acid diimidazolide
A813030
1-[1h-imidazol-1-yl(oxo)acetyl]-1h-imidazole
nsc 299886
FT-0606159
SCHEMBL618874
1,1'-oxalyl-diimidazol
ONRNRVLJHFFBJG-UHFFFAOYSA-N
1,1'-(1,2-dioxo-1,2-ethanediyl)bis-1h-imidazole
1,2-di-(1h-imidazol-1-yl)ethane-1,2-dione
DTXSID20171887
mfcd00043067
J-011961
1,1-oxalyldiimidazole
F14979
CS-0204873
AS-79145
1,1/'-oxalyldiimidazole
bis(1h-imidazol-1-yl)ethane-1,2-dione
1,2-di(1-imidazolyl)ethane-1,2-dione
SY052195
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.13 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index5.33 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
estriol
hormonin: estrogen replacement; each tablet contains 600 ug micronized 17beta-estradiol, 270 ug estriol and 1.4 mg estrone. chlorapatite : A phosphate mineral with the formula Ca5(PO4)3Cl.		2.081016alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid		estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite
melamine
melamine: RN given refers to parent cpd; structure. melamine : A trimer of cyanamide, with a 1,3,5-triazine skeleton.		7.0510triamino-1,3,5-triazinexenobiotic metabolite
perylene
Perylene: A 20-carbon dibenz(de,kl)anthracene that can be viewed as a naphthalene fused to a phenalene or as dinaphthalene. It is used as fluorescent lipid probe in the cytochemistry of membranes and is a polycyclic hydrocarbon pollutant in soil and water. Derivatives may be carcinogenic.. perylene : An ortho- and peri-fused polycyclic arene comprising of five benzene rings that is anthracene in which the d,e and k,l sides are fused to benzene rings.		2.0810ortho- and peri-fused polycyclic arene;
perylenes
resorufin
[no description available]		2.8330phenoxazine
amplex red
Amplex Red: a component of the Amplex Red Hydrogen Peroxide Assay Kit		2.5320
ochratoxin a
ochratoxin A: structure in first source & in Merck, 9th ed, #6549. ochratoxin A : A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.		2.0810isochromanes;
monocarboxylic acid amide;
N-acyl-L-phenylalanine;
organochlorine compound;
phenylalanine derivative		Aspergillus metabolite;
calcium channel blocker;
carcinogenic agent;
mycotoxin;
nephrotoxin;
Penicillium metabolite;
teratogenic agent
perylenetetracarboxylic diimide
perylenetetracarboxylic diimide: structure in first source		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
47,XX,+21
[description not available]		02.0810
Chromosomal Triplication
[description not available]		02.0810
Complete Trisomy 18 Syndrome
[description not available]		02.0810
Down Syndrome
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)		02.0810
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0710
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