1,1'-Oxalyldiimidazole is a white, crystalline solid. It is a versatile reagent used in organic synthesis. Its importance lies in its ability to activate carboxylic acids for various reactions, including amidation, esterification, and peptide coupling. It is synthesized by reacting imidazole with oxalyl chloride in the presence of a base like triethylamine. The resulting compound is highly reactive and is widely used in research due to its high efficiency in activating carboxylic acids.
1,1'-oxalyldiimidazole: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 100439 |
SCHEMBL ID | 618874 |
MeSH ID | M0553119 |
Synonym |
---|
1,2-di(1h-imidazol-1-yl)ethane-1,2-dione |
1h-imidazole, 1,1'-(1,2-dioxo-1,2-ethanediyl)bis- |
AKOS015837676 |
18637-83-7 |
nsc299886 |
nsc-299886 |
1,1'-oxalyldiimidazole, technical grade |
1,2-di(imidazol-1-yl)ethane-1,2-dione |
1,1'-oxalyldiimidazole |
O0200 |
oxalic acid diimidazolide |
A813030 |
1-[1h-imidazol-1-yl(oxo)acetyl]-1h-imidazole |
nsc 299886 |
FT-0606159 |
SCHEMBL618874 |
1,1'-oxalyl-diimidazol |
ONRNRVLJHFFBJG-UHFFFAOYSA-N |
1,1'-(1,2-dioxo-1,2-ethanediyl)bis-1h-imidazole |
1,2-di-(1h-imidazol-1-yl)ethane-1,2-dione |
DTXSID20171887 |
mfcd00043067 |
J-011961 |
1,1-oxalyldiimidazole |
F14979 |
CS-0204873 |
AS-79145 |
1,1/'-oxalyldiimidazole |
bis(1h-imidazol-1-yl)ethane-1,2-dione |
1,2-di(1-imidazolyl)ethane-1,2-dione |
SY052195 |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 7 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.13) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 8 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |