1-(piperidinomethyl)-2-naphthol is a chemical compound that has been of interest to researchers for its potential applications in various fields, including:
**1. Pharmacology and Drug Development:**
* **Antioxidant activity:** This compound has shown antioxidant properties in studies, which could make it relevant for combating oxidative stress and related diseases.
* **Anti-inflammatory activity:** Research suggests that 1-(piperidinomethyl)-2-naphthol exhibits anti-inflammatory properties, making it a potential candidate for treating inflammation-related conditions.
* **Potential for treating Alzheimer's disease:** Some studies have explored the compound's ability to inhibit the formation of amyloid-beta plaques, which are associated with Alzheimer's disease. This suggests it might be a valuable tool for further investigation in the search for Alzheimer's treatments.
**2. Materials Science:**
* **Organic electronics:** The compound's structure could potentially lend itself to applications in organic electronics, such as in the development of organic light-emitting diodes (OLEDs).
**3. Biochemistry and Chemical Biology:**
* **Probing biological systems:** The compound's fluorescent properties make it a useful tool for studying biological systems. It can be used as a probe to visualize and track certain processes within cells.
**Why it is important for research:**
The potential applications of 1-(piperidinomethyl)-2-naphthol make it a valuable subject of research. Its biological activity and potential for use in various fields create opportunities for further investigation and development. Researchers continue to study its properties and explore its potential to contribute to advancements in medicine, materials science, and other areas.
**Important Note:**
It's crucial to recognize that research on 1-(piperidinomethyl)-2-naphthol is still in its early stages. While promising, further studies are required to understand its full potential and safety for various applications.
1-(piperidinomethyl)-2-naphthol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 21436 |
| CHEMBL ID | 2005694 |
| SCHEMBL ID | 13700903 |
| MeSH ID | M0287027 |
| Synonym |
|---|
| 1-(piperidin-1-yl-methyl)-naphthalen-2-ol |
| nsc3684 |
| nsc-3684 |
| mls002637703 , |
| 5342-95-0 |
| 1-piperidin-1-ylmethyl-naphthalen-2-ol |
| ro 3-0514 |
| 2-naphthol, 1-(piperidinomethyl)- |
| alpha-piperidinomethyl-beta-naphthol |
| 2-naphthalenol, 1-(1-piperidinylmethyl)- |
| 1-(piperidinomethyl)-2-naphthol |
| ai3-23150 |
| brn 0185859 |
| 1-(1-piperidylmethyl)naphthalen-2-ol |
| 2-naphthol, 1-piperidino-methyl- |
| OPREA1_733906 |
| OPREA1_565081 |
| SR-01000635926-1 |
| MIXCOM1_000058 |
| MAYBRIDGE1_000036 , |
| smr001354233 |
| 1-(piperidin-1-ylmethyl)naphthalen-2-ol |
| AKOS000605809 |
| 1-(piperidin-1-ylmethyl)-2-naphthol |
| HMS3085I21 |
| MLS-0440404.0001 |
| 1-((piperidin-1-yl)methyl)naphthalen-2-ol |
| EN300-08750 |
| 1-[(piperidin-1-yl)methyl]naphthalen-2-ol |
| CCG-46214 |
| 5-20-02-00241 (beilstein handbook reference) |
| 1-piperidinylmethyl-2-naphthol |
| nsc 3684 |
| FT-0605862 |
| TS-00724 |
| CHEMBL2005694 |
| SCHEMBL13700903 |
| bdbm91378 |
| 1-(1-piperidinylmethyl)-2-naphthalenol |
| cid_21436 |
| DTXSID50201585 |
| mfcd00021615 |
| L10053 |
| Z44087463 |
| 1-(1-piperidinylmethyl)-2-naphthol |
| piperidinomethyl-2-naphthol |
| 1-piperidin-1-ylmethyl-2-naphthol |
| AMY10461 |
| CS-0307846 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 14.1254 | 0.0001 | 8.4406 | 100.0000 | AID720579 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| corticotropin-releasing hormone receptor 2 | Homo sapiens (human) | EC50 (µMol) | 11.9200 | 1.1200 | 11.5617 | 36.8000 | AID602473; AID651648 |
| corticotropin releasing factor-binding protein | Homo sapiens (human) | EC50 (µMol) | 11.9200 | 1.1200 | 11.5617 | 36.8000 | AID602473; AID651648 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.59) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||