Compounds > 1-(diethylaminopropyl)-4-phenylpiperazine
Page last updated: 2024-12-07
1-(diethylaminopropyl)-4-phenylpiperazine
Description
1-(diethylaminopropyl)-4-phenylpiperazine is a chemical compound with the molecular formula C18H28N2. It is also known as **loperamide**, a common antidiarrheal medication.
**Here's why it's important for research:**
* **Pharmacology:** Loperamide is a potent μ-opioid receptor agonist, meaning it binds to and activates the mu opioid receptor. This receptor is involved in various physiological processes, including pain perception, mood, and gastrointestinal function. Understanding how loperamide interacts with this receptor helps researchers learn more about the opioid system and potential therapeutic targets.
* **Drug Development:** Loperamide has been studied extensively for its potential therapeutic applications beyond diarrhea, including:
* **Pain management:** It is used to treat certain types of pain, such as post-operative pain.
* **Anti-inflammatory effects:** Loperamide has been shown to have anti-inflammatory properties, which may be useful in treating inflammatory bowel disease (IBD) and other inflammatory conditions.
* **Anti-cancer effects:** Some research suggests loperamide may have anti-cancer effects in certain types of cancer.
* **Understanding Opioid Dependence:** Studying the effects of loperamide, a relatively safe opioid, can help researchers understand the mechanisms of opioid dependence and addiction.
**Important Notes:**
* Loperamide is a powerful medication that can have serious side effects, especially at high doses. It should only be used under the supervision of a healthcare professional.
* Research on loperamide and its potential uses is ongoing, and it is important to rely on evidence-based information from reputable sources.
If you have any further questions or concerns about loperamide, please consult with a healthcare professional.
1-(diethylaminopropyl)-4-phenylpiperazine: potential brain imaging agent labeled with 125I; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 124589 |
| MeSH ID | M0140094 |
Synonyms (5)
| Synonym |
|---|
| 3-ethyl-3-(4-phenylpiperazin-1-yl)pentan-2-amine |
| 101751-95-5 |
| 1-piperazinepropanamine, n,n-diethyl-4-phenyl- |
| 1-(diethylaminopropyl)-4-phenylpiperazine |
| DTXSID30906586 |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.82
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.82 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.62 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |