You're asking about a compound with a very specific chemical name: **1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1H-benz[e]inden-3-yl)ethanone**.
**Here's what we know about this compound:**
* **Structure:** The name tells us a lot about the molecule's structure. It contains a complex ring system called a benz[e]inden, which is a fused ring system of benzene and indene. This system has 12 carbons in a fully saturated (dodecahydro) form and is also methylated (3a-methyl). Furthermore, it has a 2-hydroxyethyl group attached to the 7th position, and an ethanone group (also called a ketone) attached to the 1st position.
* **Possible Applications:**
* **Drug Research:** The complexity and unusual features of this compound suggest it might be interesting for drug discovery. The fused ring systems and functional groups can potentially interact with biological targets.
* **Materials Science:** Compounds with these kinds of complex structures could also be interesting for material science applications. For example, they might have unique optical or electronic properties.
**Why it might be important for research:**
* **Novelty:** This compound likely represents a novel chemical structure, which is always of interest in research.
* **Biological Activity:** As mentioned, the structure could potentially interact with biological systems and show interesting pharmacological activity.
* **Synthesis Challenges:** Synthesizing such a complex molecule is a challenge, and successful synthesis can lead to advancements in synthetic chemistry.
**Important Notes:**
* **Without further context, it's impossible to know exactly why this compound is being researched.** There might be a specific biological target in mind, or researchers might be exploring its synthesis and properties.
* **To find out more, you'd need to look for publications or research projects related to this specific compound.** You can use scientific databases like PubChem, SciFinder, or Google Scholar to search for information.
Let me know if you have any more questions!
1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1H-benz(e)inden-3-yl)ethanone: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 126873 |
CHEMBL ID | 209801 |
SCHEMBL ID | 8964991 |
MeSH ID | M0211842 |
Synonym |
---|
CHEMBL209801 |
bi-1 |
1-[(3s,3as,5ar,7r,9ar,9bs)-7-(2-hydroxyethyl)-3a-methyl-1,2,3,4,5,5a,6,7,8,9,9a,9b-dodecahydrocyclopenta[a]naphthalen-3-yl]ethanone |
1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1h-benz(e)inden-3-yl)ethanone |
145551-68-4 |
ethanone, 1-(dodecahyro-7-(2-hydroxyethyl)-3a-methyl-1h-benz(e)inden-3-yl)-, (3s-(3alpha,3aalpha,5abeta,7alpha,9aalpha,9bbeta))- |
3s-(3alpha,3aalpha,5abeta,7alpha,9aalpha,9bbeta)-1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1h-benz(e)inden-3-yl)ethanone |
SCHEMBL8964991 |
1-[7-(2-hydroxyethyl)-3a-methyldodecahydro-1h-cyclopenta[a]naphthalen-3-yl]ethan-1-one |
DTXSID80932638 |
Excerpt | Relevance | Reference |
---|---|---|
" Conversely, conditional over-expression of an active fragment of XIAP or genetic ablation of XIAP expression altered the apoptosis dose-response of the compounds." | ( Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors. Cuddy, M; Hanaii, F; Houghten, R; Pinilla, C; Reed, JC; Samuel, T; Schimmer, A; Wang, Z; Welsh, K, 2004) | 0.32 |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID266558 | Activity at rat GABA-Aalpha1 receptor plus beta-2-gamma-2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of GABA at 10 uM | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15 | Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
AID266555 | Activity at rat GABA-Aalpha1 receptor plus beta-2-gamma-2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of compound at 0.1 uM | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15 | Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
AID266554 | Displacement of [35S]TBPS from GABA-A receptor in rat brain membrane | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15 | Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
AID266556 | Activity at rat GABA-Aalpha1 receptor plus beta2gamma2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of compound at 1 uM | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15 | Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
AID266559 | Loss of righting reflex in Xenopus laevis tadpole | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15 | Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
AID266557 | Activity at rat GABA-Aalpha1 receptor plus beta-2-gamma-2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of compound at 10 uM | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15 | Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
AID266560 | Loss of swimming reflex in Xenopus laevis tadpole | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15 | Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (33.33) | 18.2507 |
2000's | 2 (33.33) | 29.6817 |
2010's | 1 (16.67) | 24.3611 |
2020's | 1 (16.67) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 6 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |