Page last updated: 2024-12-07

1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1h-benz(e)inden-3-yl)ethanone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

You're asking about a compound with a very specific chemical name: **1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1H-benz[e]inden-3-yl)ethanone**.

**Here's what we know about this compound:**

* **Structure:** The name tells us a lot about the molecule's structure. It contains a complex ring system called a benz[e]inden, which is a fused ring system of benzene and indene. This system has 12 carbons in a fully saturated (dodecahydro) form and is also methylated (3a-methyl). Furthermore, it has a 2-hydroxyethyl group attached to the 7th position, and an ethanone group (also called a ketone) attached to the 1st position.
* **Possible Applications:**
* **Drug Research:** The complexity and unusual features of this compound suggest it might be interesting for drug discovery. The fused ring systems and functional groups can potentially interact with biological targets.
* **Materials Science:** Compounds with these kinds of complex structures could also be interesting for material science applications. For example, they might have unique optical or electronic properties.

**Why it might be important for research:**

* **Novelty:** This compound likely represents a novel chemical structure, which is always of interest in research.
* **Biological Activity:** As mentioned, the structure could potentially interact with biological systems and show interesting pharmacological activity.
* **Synthesis Challenges:** Synthesizing such a complex molecule is a challenge, and successful synthesis can lead to advancements in synthetic chemistry.

**Important Notes:**

* **Without further context, it's impossible to know exactly why this compound is being researched.** There might be a specific biological target in mind, or researchers might be exploring its synthesis and properties.
* **To find out more, you'd need to look for publications or research projects related to this specific compound.** You can use scientific databases like PubChem, SciFinder, or Google Scholar to search for information.

Let me know if you have any more questions!

1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1H-benz(e)inden-3-yl)ethanone: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID126873
CHEMBL ID209801
SCHEMBL ID8964991
MeSH IDM0211842

Synonyms (10)

Synonym
CHEMBL209801
bi-1
1-[(3s,3as,5ar,7r,9ar,9bs)-7-(2-hydroxyethyl)-3a-methyl-1,2,3,4,5,5a,6,7,8,9,9a,9b-dodecahydrocyclopenta[a]naphthalen-3-yl]ethanone
1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1h-benz(e)inden-3-yl)ethanone
145551-68-4
ethanone, 1-(dodecahyro-7-(2-hydroxyethyl)-3a-methyl-1h-benz(e)inden-3-yl)-, (3s-(3alpha,3aalpha,5abeta,7alpha,9aalpha,9bbeta))-
3s-(3alpha,3aalpha,5abeta,7alpha,9aalpha,9bbeta)-1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1h-benz(e)inden-3-yl)ethanone
SCHEMBL8964991
1-[7-(2-hydroxyethyl)-3a-methyldodecahydro-1h-cyclopenta[a]naphthalen-3-yl]ethan-1-one
DTXSID80932638

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Conversely, conditional over-expression of an active fragment of XIAP or genetic ablation of XIAP expression altered the apoptosis dose-response of the compounds."( Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors.
Cuddy, M; Hanaii, F; Houghten, R; Pinilla, C; Reed, JC; Samuel, T; Schimmer, A; Wang, Z; Welsh, K, 2004
)
0.32
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID266558Activity at rat GABA-Aalpha1 receptor plus beta-2-gamma-2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of GABA at 10 uM2006Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes.
AID266555Activity at rat GABA-Aalpha1 receptor plus beta-2-gamma-2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of compound at 0.1 uM2006Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes.
AID266554Displacement of [35S]TBPS from GABA-A receptor in rat brain membrane2006Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes.
AID266556Activity at rat GABA-Aalpha1 receptor plus beta2gamma2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of compound at 1 uM2006Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes.
AID266559Loss of righting reflex in Xenopus laevis tadpole2006Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes.
AID266557Activity at rat GABA-Aalpha1 receptor plus beta-2-gamma-2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of compound at 10 uM2006Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes.
AID266560Loss of swimming reflex in Xenopus laevis tadpole2006Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's2 (33.33)29.6817
2010's1 (16.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]