Page last updated: 2024-12-09

1-(4-methoxyphenyl)-2-(5-thiophen-2-yl-2-tetrazolyl)ethanone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

The compound you described, **1-(4-methoxyphenyl)-2-(5-thiophen-2-yl-2-tetrazolyl)ethanone**, is a **heterocyclic compound** with a complex structure. It features a **tetrazole ring** attached to a **thiophene ring** and a **methoxyphenyl group** linked to a **ketone** functional group.

**Importance in Research:**

While the compound itself might not be a widely studied entity, its structural features suggest potential areas of interest in research:

* **Pharmaceutical Applications:** The presence of a tetrazole ring is commonly found in various pharmaceuticals. Tetrazoles are known for their **bioactivity** and potential to interact with biological targets. The thiophene ring is also known to contribute to biological activity in certain compounds. This complex structure could be investigated for its potential as a drug candidate for various conditions.
* **Material Science:** The combination of aromatic rings and heteroatoms (sulfur and nitrogen) could impart interesting **electronic properties** to the molecule. This could be relevant for research on materials with specific conductivity, optical properties, or potential applications in organic electronics.
* **Synthetic Chemistry:** The compound could serve as a valuable building block for the synthesis of other novel heterocyclic compounds. Exploring its reactivity and potential for further functionalization could lead to the discovery of new chemical entities with unique properties.

**Further Research:**

To assess the true importance of this specific compound, it's necessary to delve into the existing literature and potentially conduct further research. Key aspects to explore include:

* **Synthesis:** How was the compound synthesized? Are there efficient and scalable routes available?
* **Biological Activity:** Does it exhibit any biological activity, and if so, what is its mechanism of action?
* **Physical Properties:** What are its melting point, solubility, and other relevant physical properties?
* **Applications:** Has it been investigated for any specific applications, such as drug development, material science, or other fields?

By investigating these aspects, researchers can gain a deeper understanding of the potential applications and importance of 1-(4-methoxyphenyl)-2-(5-thiophen-2-yl-2-tetrazolyl)ethanone.

Cross-References

ID SourceID
PubMed CID650045
CHEMBL ID1588851
CHEBI ID114435

Synonyms (11)

Synonym
OPREA1_468786
smr000002260
MLS000028217 ,
ASN 03366275
1-(4-methoxy-phenyl)-2-(5-thiophen-2-yl-tetrazol-2-yl)-ethanone
CHEBI:114435
1-(4-methoxyphenyl)-2-(5-thiophen-2-yltetrazol-2-yl)ethanone
HMS2409M22
CHEMBL1588851
Q27195836
1-(4-methoxyphenyl)-2-(5-thiophen-2-yl-2-tetrazolyl)ethanone
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
aromatic ketoneA ketone in which the carbonyl group is attached to an aromatic ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (9)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency9.52830.007215.758889.3584AID588342
ATAD5 protein, partialHomo sapiens (human)Potency5.80480.004110.890331.5287AID504467
TDP1 proteinHomo sapiens (human)Potency2.31090.000811.382244.6684AID686978
P53Homo sapiens (human)Potency11.22020.07319.685831.6228AID504706
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency3.54810.01262.451825.0177AID485313
chromobox protein homolog 1Homo sapiens (human)Potency89.12510.006026.168889.1251AID540317
DNA polymerase betaHomo sapiens (human)Potency0.28180.022421.010289.1251AID485314
ras-related protein Rab-9AHomo sapiens (human)Potency2.81840.00022.621531.4954AID485297
VprHuman immunodeficiency virus 1Potency39.81071.584919.626463.0957AID651644
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]