Compounds > 1-(4-hydroxyphenyl)-7-phenyl-(6E)-hept-6-en-3-one
Page last updated: 2024-11-13
1-(4-hydroxyphenyl)-7-phenyl-(6E)-hept-6-en-3-one
Description
You're describing a molecule with a rather complex name! Let's break it down and explore its potential significance:
**Understanding the Structure**
* **1-(4-hydroxyphenyl)-7-phenyl-(6E)-hept-6-en-3-one** is a chemical compound with a specific structure:
* **1-(4-hydroxyphenyl):** This part indicates a phenyl ring (a 6-carbon ring with alternating single and double bonds) with a hydroxyl group (-OH) attached to the 4th carbon.
* **7-phenyl:** Another phenyl ring attached to the 7th carbon of the main chain.
* **(6E)-hept-6-en-3-one:** This tells us:
* **(6E):** There's a double bond between the 6th and 7th carbons, with a specific arrangement of atoms around it (E configuration).
* **hept:** The main chain has 7 carbons.
* **-6-en:** The double bond is located at the 6th carbon.
* **-3-one:** A ketone group (C=O) is attached to the 3rd carbon.
**Visualizing the Compound**
Imagine a 7-carbon chain with a ketone group in the middle. One end has a phenyl ring attached, while the other has a phenyl ring with a hydroxyl group. There's a double bond between the 6th and 7th carbons.
**Potential Research Importance**
While the exact biological properties of this specific molecule are not readily available in public databases, compounds with similar structures are known to have various biological activities. Here's why this compound could be interesting for research:
* **Potential Drug Candidates:** Molecules containing phenyl rings, ketones, and double bonds often exhibit pharmacological activity. The specific arrangement of these functional groups could influence the molecule's interactions with biological targets, making it a potential candidate for drug development.
* **Structure-Activity Relationships:** Researchers often study similar compounds to understand the structure-activity relationship. By modifying the compound's structure (e.g., adding or removing functional groups), researchers can gain insights into how its activity changes, potentially leading to the design of more effective drugs.
* **Synthetic Chemistry:** The compound itself might be a useful intermediate for synthesizing other compounds with specific properties, or its synthesis might pose interesting synthetic challenges, contributing to the development of new synthetic methods.
**Finding More Information**
To understand the specific importance of this compound for research, you would need additional information. This includes:
* **Published Research:** Has this compound been studied in any published scientific papers?
* **Database Searches:** Are there any databases (like PubChem, ChemSpider, or scientific literature databases) that contain information on this molecule?
* **Expert Consultation:** Consulting with a chemist or researcher specializing in organic synthesis or drug discovery could provide further insights.
Let me know if you have more details about the context in which you encountered this molecule, and I might be able to offer more specific insights!
1-(4-hydroxyphenyl)-7-phenyl-(6E)-hept-6-en-3-one : A diarylheptanoid that is hept-6-en-3-one substituted by a 4-hydroxyphenyl group at position 1 and a phenyl group at position 7 respectively. It has been isolated from the rhizomes of Curcuma kwangsiensis. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
Synonyms (6)
Synonym |
chebi:70699 , |
CHEMBL461084 |
1-(4-hydroxyphenyl)-7-phenyl-(6e)-hept-6-en-3-one |
(6e)-1-(4-hydroxyphenyl)-7-phenylhept-6-en-3-one |
1-(4-hydroxyphenyl)-7-phenyl-(6e)-6-hepten-3-one |
Q27139030 |
Roles (1)
Role | Description |
plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (3)
Class | Description |
diarylheptanoid | A family of plant metabolites with a common 1,7-diphenylheptane structural skeleton, carrying various substituents. They are mainly distributed in the roots, rhizomes and bark of Alpinia, Zingiber, Curcuma and Alnus species. |
ketone | A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H). |
phenols | Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Bioassays (5)
Assay ID | Title | Year | Journal | Article |
AID343664 | Estrogenic activity in human HeLa cells assessed as ERbeta gene transcriptional activity at 10 nM after 24 hrs by RT-PCR relative to 17-beta-estradiol | 2008 | Bioorganic & medicinal chemistry, Jul-15, Volume: 16, Issue:14
| Diarylheptanoids, new phytoestrogens from the rhizomes of Curcuma comosa: Isolation, chemical modification and estrogenic activity evaluation. |
AID343663 | Estrogenic activity in human HeLa cells assessed as Bcl-xL gene transcriptional activity at 10 nM after 24 hrs by RT-PCR relative to 17-beta-estradiol | 2008 | Bioorganic & medicinal chemistry, Jul-15, Volume: 16, Issue:14
| Diarylheptanoids, new phytoestrogens from the rhizomes of Curcuma comosa: Isolation, chemical modification and estrogenic activity evaluation. |
AID1868993 | Cytotoxicity against mouse RAW264.7 cells assessed as effect on cell viability at 5 uM incubated for 24 hrs by alamar blue reagent based fluorescence assay | 2022 | Bioorganic & medicinal chemistry, 07-15, Volume: 66 | Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo. |
AID1868991 | Inhibition of LPS-induced NO production in mouse RAW264.7 cells at 5 uM preincubated with compound for 2 hrs followed by LPS stimulation for 24 hrs by Griess reagent based assay relative to control | 2022 | Bioorganic & medicinal chemistry, 07-15, Volume: 66 | Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo. |
AID527190 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by MTT assay | 2010 | Journal of natural products, Oct-22, Volume: 73, Issue:10
| Diarylheptanoids from the Rhizomes of Curcuma kwangsiensis. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (5)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 3 (60.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.87
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
Metric | This Compound (vs All) |
---|
Research Demand Index | 12.87 (24.57) | Research Supply Index | 1.79 (2.92) | Research Growth Index | 4.66 (4.65) | Search Engine Demand Index | 0.00 (26.88) | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |