Page last updated: 2024-12-09

1-(4-chlorophenyl)-3-(2-phenylethyl)thiourea

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1-(4-chlorophenyl)-3-(2-phenylethyl)thiourea is a chemical compound, often referred to as **CPTU**. It's not a commonly known molecule, and there's limited information available on its specific research significance.

However, based on its chemical structure, we can make some educated guesses about its potential properties and research interest:

**Structure and Potential Properties:**

* **Thiourea derivative:** CPTU contains the thiourea functional group, which is known for its ability to form hydrogen bonds and participate in various chemical reactions. This suggests potential applications in fields like:
* **Pharmacology:** Thiourea derivatives are often explored for their potential biological activities, such as antimicrobial, anti-inflammatory, or anticancer properties.
* **Materials Science:** Thioureas can act as ligands in coordination chemistry, potentially forming complexes with metals for applications in catalysis, sensing, or material synthesis.

* **Aromatic rings:** The presence of phenyl rings (benzene rings) suggests potential for:
* **Enhanced lipophilicity:** Aromatic compounds tend to be more soluble in fats and lipids, which could affect their biological activity or pharmacokinetic profile.
* **Stability:** Aromatic rings are generally stable and can contribute to the overall stability of the molecule.

* **Chlorine substitution:** The chlorine atom on the phenyl ring might:
* **Increase lipophilicity:** Chlorine is electron-withdrawing, which could further enhance the molecule's solubility in fats and lipids.
* **Influence biological activity:** The chlorine atom could modify the molecule's interactions with biological targets, affecting its efficacy and/or selectivity.

**Research Importance:**

The lack of readily available research on CPTU specifically makes it difficult to pinpoint its importance. However, considering its structure and potential properties, it could be relevant to research in the following areas:

* **Drug discovery:** Synthesizing and evaluating CPTU and related compounds could lead to the identification of new drug candidates with potential therapeutic benefits.
* **Materials science:** Studying the coordination chemistry of CPTU with metals could lead to the development of new materials with unique properties for various applications.
* **Biological activity:** CPTU might exhibit specific biological activities, which could be investigated to understand its potential in fields like pharmacology or toxicology.

**Further Research:**

To understand the true significance of CPTU in research, more research is required. This might involve:

* **Synthesis and characterization:** Developing efficient methods for synthesizing and characterizing CPTU.
* **Biological activity testing:** Evaluating the potential biological activities of CPTU in various biological systems (e.g., bacteria, cells, animal models).
* **Structure-activity relationship studies:** Investigating how modifications to the molecule's structure affect its biological activity.

Without more specific information about the research context or specific properties of CPTU, it is difficult to provide a definitive answer regarding its importance. However, its structural features suggest potential applications in several fields, highlighting the need for further investigation to uncover its full potential.

Cross-References

ID SourceID
PubMed CID878760
CHEMBL ID1548970
CHEBI ID104965
SCHEMBL ID6955649

Synonyms (15)

Synonym
OPREA1_316434
smr000193954
n-(4-chlorophenyl)-n'-(2-phenylethyl)thiourea
MLS000571936
STK144144
1-(4-chlorophenyl)-3-(2-phenylethyl)thiourea
CHEBI:104965
AKOS001018646
n'-(4-chlorophenyl)-n-(2-phenylethyl)carbamimidothioic acid
STK965250
HMS2552O19
CHEMBL1548970
SCHEMBL6955649
Q27182634
Z45795097
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
thioureasCompounds of general formula RR'NC(=S)NR''R'''.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (13)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Beta-lactamaseEscherichia coli K-12Potency0.35480.044717.8581100.0000AID485294
LuciferasePhotinus pyralis (common eastern firefly)Potency16.94410.007215.758889.3584AID588342
glp-1 receptor, partialHomo sapiens (human)Potency14.12540.01846.806014.1254AID624417
BRCA1Homo sapiens (human)Potency11.22020.89137.722525.1189AID624202
ATAD5 protein, partialHomo sapiens (human)Potency20.59620.004110.890331.5287AID504467
TDP1 proteinHomo sapiens (human)Potency12.60360.000811.382244.6684AID686978; AID686979
Microtubule-associated protein tauHomo sapiens (human)Potency39.81070.180013.557439.8107AID1468
Smad3Homo sapiens (human)Potency22.38720.00527.809829.0929AID588855
P53Homo sapiens (human)Potency39.81070.07319.685831.6228AID504706
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency50.11873.548119.542744.6684AID743266
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency13.13110.00798.23321,122.0200AID2546; AID2551
gemininHomo sapiens (human)Potency29.09290.004611.374133.4983AID624296
survival motor neuron protein isoform dHomo sapiens (human)Potency10.00000.125912.234435.4813AID1458
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]