Page last updated: 2024-12-10

1-(3-chloro-4-methoxyphenyl)-3-(2-fluorophenyl)urea

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

## 1-(3-chloro-4-methoxyphenyl)-3-(2-fluorophenyl)urea: Structure and Potential Importance

1-(3-chloro-4-methoxyphenyl)-3-(2-fluorophenyl)urea is a chemical compound with the following structural formula:

**Structure:**

```
Cl
\\
C
/ \\
O OCH3
\\ /
C
/ \\
H NH
\\
C
/ \\
H NH
\\
C
/ \\
H F
/
C
/ \\
H H
```

**Importance in Research:**

While specific information about this compound's research significance is not readily available, its structure suggests potential applications in various fields:

**1. Pharmaceutical Research:**

* **Potential Drug Candidate:** The presence of a urea group and aromatic rings with substituents like chlorine, fluorine, and methoxy groups indicates that this molecule could possess biological activity. It could be a potential lead compound for developing drugs targeting various disease areas.
* **Drug Delivery:** The urea group can act as a hydrogen bond donor, potentially facilitating interaction with biological targets and enhancing drug delivery.

**2. Material Science:**

* **Polymer Synthesis:** The urea group can participate in polymerization reactions, potentially leading to the synthesis of novel polymers with specific properties.

**3. Agricultural Research:**

* **Herbicide or Pesticide:** The aromatic rings and substituents might give this compound herbicidal or pesticidal activity, depending on the specific structure and modifications.

**4. Chemical Biology Research:**

* **Probing Protein Interactions:** The compound could act as a tool to probe protein-protein interactions due to its potential to form hydrogen bonds and interact with specific amino acid residues.

**5. Environmental Research:**

* **Bioremediation:** The structure might influence the molecule's ability to degrade pollutants in the environment, potentially contributing to bioremediation strategies.

**Note:** This information is based on general knowledge about the chemical structure and potential applications of compounds with similar characteristics. Further research is required to determine the specific properties and importance of 1-(3-chloro-4-methoxyphenyl)-3-(2-fluorophenyl)urea in different scientific fields.

It is essential to consult relevant scientific literature and databases to gain a comprehensive understanding of its potential applications.

Cross-References

ID SourceID
PubMed CID4460240
CHEMBL ID1518603
CHEBI ID105637

Synonyms (10)

Synonym
HMS2623E16
n-(3-chloro-4-methoxyphenyl)-n'-(2-fluorophenyl)urea
smr000297513
MLS000679238
STK476143
1-(3-chloro-4-methoxyphenyl)-3-(2-fluorophenyl)urea
CHEBI:105637
AKOS003316248
CHEMBL1518603
Q27183393
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
ureas
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (8)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency2.13310.007215.758889.3584AID588342
thioredoxin reductaseRattus norvegicus (Norway rat)Potency89.12510.100020.879379.4328AID588453
BRCA1Homo sapiens (human)Potency1.77830.89137.722525.1189AID624202
ATAD5 protein, partialHomo sapiens (human)Potency4.63960.004110.890331.5287AID504466; AID504467
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency1.77830.01262.451825.0177AID485313
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency1.83560.00419.984825.9290AID504444
ras-related protein Rab-9AHomo sapiens (human)Potency1.41250.00022.621531.4954AID485297
survival motor neuron protein isoform dHomo sapiens (human)Potency10.00000.125912.234435.4813AID1458
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]