1-(2-chloroethyl)-3-(1-oxyl-2,2,6,6-tetramethylpiperidinyl)-1-nitrosourea profile

1-(2-chloroethyl)-3-(1-oxyl-2,2,6,6-tetramethylpiperidinyl)-1-nitrosourea: has more antineoplastic activity & less toxicity than CCNU; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	134164
MeSH ID	M0131160

Synonym
unii-w77mz42gar
slnu
slcnu
1-(2-chloroethyl)-3-(1-oxyl-2,2,6,6-tetramethylpiperidinyl)-1-nitrosourea
nu 2
brn 5985884
83144-41-6
DTXSID401003160
[4-({[(2-chloroethyl)(nitroso)amino](hydroxy)methylidene}amino)-2,2,6,6-tetramethylpiperidin-1-yl]oxidanyl

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (42.86)	18.7374
1990's	1 (14.29)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	3 (42.86)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
lomustine [no description available]	1.96	1	N-nitrosoureas; organochlorine compound	alkylating agent; antineoplastic agent
triethylenephosphoramide Triethylenephosphoramide: An insect chemosterilant and an antineoplastic agent.	1.97	1	phosphoramide
methylnitrosourea Methylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-methyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.	1.97	1	N-nitrosoureas	alkylating agent; carcinogenic agent; mutagen; teratogenic agent
ethylnitrosourea Ethylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-ethyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.	3.25	6	N-nitrosoureas	alkylating agent; carcinogenic agent; genotoxin; mutagen
enbucrilate Enbucrilate: A tissue adhesive that is applied as a monomer to moist tissue and polymerizes to form a bond. It is slowly biodegradable and used in all kinds of surgery, including dental.	1.98	1	alpha,beta-unsaturated monocarboxylic acid; nitrile

Condition	Relationship Strength	Studies
Hepatocellular Carcinoma [description not available]	2.41	1
Cancer of Liver [description not available]	2.41	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.41	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.41	1
Carcinogenesis The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.	2.6	1
Adenocarcinoma, Basal Cell [description not available]	2.6	1
Cancer of Lung [description not available]	2.45	2
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.6	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.45	2
Bunyaviridae Infections Virus diseases caused by the BUNYAVIRIDAE.	2.6	1
Severe Fever with Thrombocytopenia Syndrome A tick-borne infection with SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME BUNYAVIRUS of the genus Phlebovirus. It is associated with fever, THROMBOCYTOPENIA; LEUKOCYTOPENIA, and multiorgan dysfunction. It is found in parts of Asia including China, Japan, Korea and Vietnam and can be transmitted from infected domestic animals and humans.	2.6	1
Bone Cancer [description not available]	1.97	1
Osteogenic Sarcoma [description not available]	1.97	1
Experimental Mammary Neoplasms [description not available]	1.97	1
Bone Neoplasms Tumors or cancer located in bone tissue or specific BONES.	1.97	1
Osteosarcoma A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)	1.97	1
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	1.96	1

1-(2-chloroethyl)-3-(1-oxyl-2,2,6,6-tetramethylpiperidinyl)-1-nitrosourea

Description

Cross-References

Synonyms (9)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.24

Study Types