1-(2-chloro-4-nitrophenyl)-4-(2-methoxyphenyl)piperazine

1-(2-chloro-4-nitrophenyl)-4-(2-methoxyphenyl)piperazine is a chemical compound that is often referred to as **CP-101,606**. It is a potent and selective **dopamine D2 receptor antagonist**. This means it blocks the effects of dopamine, a neurotransmitter that plays a crucial role in many brain functions, including motivation, reward, and movement.

**Why is it important for research?**

CP-101,606 is important for research for several reasons:

* **Understanding dopamine function:** As a selective D2 antagonist, it is a valuable tool for investigating the role of dopamine in various neurological and psychiatric conditions.
* **Potential therapeutic applications:** Its ability to block dopamine signaling has led to investigations of its potential for treating conditions such as:
* **Schizophrenia:** Dopamine hyperactivity is thought to be involved in the symptoms of schizophrenia, and D2 antagonists like CP-101,606 have been studied as potential antipsychotic drugs.
* **Addiction:** Dopamine plays a key role in reward and addiction, and D2 antagonists like CP-101,606 have been investigated for their potential to reduce drug craving and relapse.
* **Parkinson's disease:** Although Parkinson's is primarily associated with dopamine depletion, some researchers have explored the use of D2 antagonists to manage certain symptoms.
* **Neurobiology research:** CP-101,606 is used in preclinical research to study the neurobiology of dopamine signaling, including its role in learning, memory, and movement.

**It is important to note:** CP-101,606 is not currently approved for any medical use. Research into its therapeutic potential is ongoing.

**Additionally:** CP-101,606 has also been studied for its effects on other neurotransmitter systems, including serotonin and norepinephrine. It is a complex compound with diverse pharmacological actions, making it a valuable tool for exploring the intricacies of the brain.