1-(2-aminoethyl)-3-phenylthiourea is a chemical compound with the molecular formula C9H13N3S. It is a derivative of thiourea, a molecule known for its diverse applications in various fields.
Here's a breakdown of its structure and potential importance for research:
**Structure:**
* **Thiourea backbone:** The molecule contains a thiourea group (NH2-C(=S)-NH2), where sulfur replaces oxygen in the urea structure.
* **Phenyl substituent:** A phenyl group (C6H5) is attached to one of the nitrogen atoms in the thiourea backbone.
* **2-aminoethyl substituent:** An aminoethyl group (NH2-CH2-CH2-) is attached to the other nitrogen atom in the thiourea backbone.
**Potential Importance in Research:**
While specific research on 1-(2-aminoethyl)-3-phenylthiourea is limited, its structural features suggest potential applications in diverse fields:
* **Pharmaceutical Research:**
* **Antimicrobial activity:** Thiourea derivatives often exhibit antimicrobial properties due to their ability to bind to metal ions, disrupting cellular processes.
* **Anticancer activity:** Certain thiourea derivatives have shown potential for inhibiting tumor growth.
* **Anti-inflammatory activity:** Some thiourea compounds demonstrate anti-inflammatory effects by modulating inflammatory pathways.
* **Materials Science:**
* **Polymer chemistry:** Thiourea derivatives can be used as monomers for synthesizing polymers with unique properties.
* **Catalysis:** The sulfur atom in thiourea can act as a Lewis base, potentially contributing to catalytic activity in various reactions.
* **Analytical Chemistry:**
* **Spectroscopic analysis:** Thiourea derivatives can be used as reagents for spectroscopic analysis, including UV-Vis and fluorescence spectroscopy.
* **Biochemistry:**
* **Enzyme inhibition:** Thiourea derivatives can act as inhibitors for certain enzymes, making them useful for studying enzyme mechanisms.
**Important Note:**
Further research is necessary to fully understand the properties and potential applications of 1-(2-aminoethyl)-3-phenylthiourea. Its biological activity, safety, and effectiveness in specific applications require careful investigation.
**Disclaimer:**
I am an AI chatbot and cannot provide medical or research advice. This information is for general knowledge only and should not be taken as a substitute for professional advice.
1-(2-aminoethyl)-3-phenylthiourea: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 2143454 |
| CHEMBL ID | 1192304 |
| SCHEMBL ID | 4397993 |
| MeSH ID | M0161562 |
| Synonym |
|---|
| HMS1786B07 |
| thiourea, n-(2-aminoethyl)-n'-phenyl- |
| 1-aept |
| 31090-77-4 |
| SDCCGMLS-0065497.P001 , |
| OPREA1_068838 |
| AKOS000267294 |
| 1-(2-aminoethyl)-3-phenylthiourea |
| CHEMBL1192304 |
| F0856-0086 |
| SASBDWJDZUQEAL-UHFFFAOYSA-N |
| n-(2-aminoethyl)-n'-phenylthiourea |
| SCHEMBL4397993 |
| DTXSID90185037 |
| Z56814594 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.85) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||