1-(2',4',5-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline

Description

You're describing a compound that's very likely related to **tetrahydroisoquinoline alkaloids (TIQAs)**, which are a class of natural products known for their diverse biological activities.

Here's what we can infer about the compound based on its name:

* **1-(2',4',5-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline:**

* **1,2,3,4-tetrahydroisoquinoline:** This is the core structure, a ring system common to TIQAs.
* **6,7-dihydroxy:** Indicates two hydroxyl (OH) groups attached to the 6th and 7th positions of the tetrahydroisoquinoline ring. This pattern is often associated with potent biological activities.
* **1-(2',4',5-trimethoxybenzyl):** This describes a substituent attached to the 1st position of the ring. It's a benzyl group (CH2-Ph) with three methoxy (OCH3) groups at positions 2', 4', and 5' on the phenyl ring.

**Importance in research:**

TIQAs like the one you described are of interest due to their:

* **Pharmacological activities:** They exhibit a broad range of biological activities, including:
* **Anti-cancer:** Some TIQAs have been shown to inhibit tumor growth and induce apoptosis.
* **Anti-inflammatory:** They can reduce inflammation by modulating signaling pathways involved in immune response.
* **Anti-bacterial:** Some TIQAs possess antimicrobial properties against various bacterial species.
* **Anti-viral:** Certain TIQAs show promising activity against viral infections.
* **Neurological:** They may have potential applications in treating neurological disorders due to their effects on neurotransmitter systems.

* **Chemical diversity:** TIQAs come in various structural variations with different substitution patterns. This makes them a valuable source for discovering new lead compounds for drug development.

**Research focus:**

Research on TIQAs is focused on:

* **Isolation and identification:** Scientists work on identifying new TIQAs from natural sources like plants and fungi.
* **Structure-activity relationship studies:** They investigate how modifications to the TIQA structure affect its biological activity.
* **Synthesis:** Developing efficient synthetic routes to produce TIQAs and their analogs for further research.
* **Preclinical studies:** Evaluating the therapeutic potential of TIQAs in animal models of diseases.

**To get a more precise understanding of the importance of this specific compound, we'd need additional context:**

* **Source:** Where was this compound isolated from (plant, fungus)?
* **Biological activity:** What specific activities has this compound been shown to possess?
* **Research context:** What specific research question is being addressed using this compound?

By providing more information, we can better understand the significance of this specific 1-(2',4',5-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline in scientific research.

1-(2',4',5-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline: 2',4',5'-trimethoxy analog of trimethoquinol; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]