Page last updated: 2024-12-07

1-(2-(decylthio)ethyl)azacyclopentane-2-one

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

The compound 1-(2-(decylthio)ethyl)azacyclopentane-2-one, also known as **Decylthioethyl-2-pyrrolidone**, is a synthetic molecule with potential applications in various research fields. Here's a breakdown of its features and significance:

**Structure and Properties:**

* **Basic Structure:** It's a pyrrolidone derivative, meaning it has a five-membered cyclic amide (pyrrolidone) ring.
* **Substituents:** A decylthioethyl group is attached to the nitrogen atom of the pyrrolidone ring. This long, hydrophobic alkyl chain with a sulfur atom gives the molecule unique properties.

**Potential Research Applications:**

1. **Drug Delivery and Targeting:**
* **Hydrophobic Interactions:** The decylthioethyl chain allows the molecule to interact with hydrophobic cell membranes. This can be exploited for targeted drug delivery.
* **Drug Conjugation:** The pyrrolidone ring can be modified to attach other drugs or therapeutic agents, making it a potential carrier for drug delivery.

2. **Biomaterial Development:**
* **Surface Modification:** The molecule's ability to interact with hydrophobic surfaces could be used to modify biomaterials for improved biocompatibility or to create specific coatings.
* **Tissue Engineering:** It could potentially play a role in designing scaffolds for tissue regeneration.

3. **Chemical Synthesis and Catalysis:**
* **Catalyst Design:** The presence of the sulfur atom in the molecule could make it a potential building block for designing new catalysts.
* **Organic Synthesis:** Its reactive functional groups (amide and sulfide) could be utilized for various organic synthesis reactions.

**Importance in Research:**

* **Novel Properties:** The combination of a pyrrolidone ring and a long alkyl chain with sulfur creates unique properties not found in common compounds. This makes it a valuable research target for exploring new applications.
* **Multidisciplinary Applications:** Its potential applications span various disciplines, including medicinal chemistry, materials science, and organic chemistry.
* **Therapeutic Potential:** The drug delivery and biomaterial applications hold promise for developing novel therapies and treatments.

**Note:** While this molecule shows promise, it's essential to remember that it is still in the research phase. Further studies are necessary to fully understand its properties, safety, and effectiveness before any potential applications can be realized.

1-(2-(decylthio)ethyl)azacyclopentane-2-one: used as a penetration enhancer for topical applications [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID124240
SCHEMBL ID463370
MeSH IDM0203942

Synonyms (16)

Synonym
2-pyrrolidinone, 1-(2-(decylthio)ethyl)-
1-(2-(decylthio)ethyl)-2-pyrrolidinone
hpe 101
pirotiodecane
1-(2-decylsulfanylethyl)pyrrolidin-2-one
1-(2-(decylthio)ethyl)azacyclopentane-2-one
unii-9idr04c5r7
9idr04c5r7 ,
113855-10-0
1-(2-decylthioethyl)pyrrolidin-2-one
hpe-101
1-(2-(decylthio)ethyl)azacyclopentan-2-one
SCHEMBL463370
DTXSID80150592
1-[2-(decylthio)ethyl]azacyclopentan-2-one
Q27272599

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" HPE-101 increased the transdermal absorption rate of VPA by 80 times compared with the control."( In vivo microdialysis for the transdermal absorption of valproate in rats.
Goto, S; Ichikawa, M; Matsuyama, K; Nakashima, M; Satoh, S; Yano, T, 1994
)
0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's7 (58.33)18.2507
2000's4 (33.33)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.73

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.73 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.73)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]