Page last updated: 2024-12-10

1-(1-benzotriazolyl)-3-(2-methylphenoxy)-2-propanol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1-(1-benzotriazolyl)-3-(2-methylphenoxy)-2-propanol, often referred to as **UV-328**, is a compound that has gained significance in research due to its **potent UV-absorbing properties**.

Here's a breakdown of its importance:

**1. UV-Absorber:**
* **Mechanism:** UV-328 acts as a **UV-absorber**, meaning it can absorb harmful ultraviolet (UV) radiation, preventing it from damaging materials or biological systems.
* **Applications:** This property makes it valuable in:
* **Sunscreens and cosmetics:** Protecting skin from sunburn and premature aging caused by UV exposure.
* **Polymers and plastics:** Preventing degradation and discoloration caused by UV exposure, increasing their lifespan.
* **Optical coatings:** Enhancing the performance of lenses and other optical components by minimizing UV absorption.

**2. Research Interest:**
* **Novel UV-absorbers:** UV-328 is part of a class of **benzotriazole-based UV absorbers** that have attracted significant research interest. Researchers are continuously seeking to optimize the structure and functionality of these compounds to enhance their UV absorption capabilities and improve their properties, like water solubility and biocompatibility.
* **Photostability:** UV-328 exhibits good **photostability** (resistance to degradation by UV light), making it suitable for long-term applications. This property is crucial for its effectiveness in protecting materials and biological systems.
* **Environmental safety:** The **environmental impact** of UV-328 and other benzotriazole-based UV absorbers is a subject of ongoing research, with concerns regarding their potential toxicity and persistence in the environment.

**3. Specific Research Applications:**
* **Biomedical research:** UV-328 has shown potential as a **photoprotective agent** in cell culture studies, protecting cells from UV-induced damage.
* **Materials science:** Researchers are exploring its use in **nanomaterials** to create novel UV-absorbing coatings with enhanced properties.

**Overall, 1-(1-benzotriazolyl)-3-(2-methylphenoxy)-2-propanol (UV-328) is an important compound in research due to its potent UV-absorbing properties, its photostability, and its potential applications in diverse fields, including sunscreens, polymers, optics, and biomedical research.** However, further research is required to fully understand its environmental impact and optimize its properties for specific applications.

Cross-References

ID SourceID
PubMed CID3133140
CHEMBL ID1432416
CHEBI ID105077

Synonyms (14)

Synonym
smr000121512
MLS000529037
1-benzotriazol-1-yl-3-o-tolyloxy-propan-2-ol
CHEBI:105077
1-(benzotriazol-1-yl)-3-(2-methylphenoxy)propan-2-ol
HMS2314N13
AKOS022132498
STL336800
1-(1h-benzotriazol-1-yl)-3-(2-methylphenoxy)propan-2-ol
CHEMBL1432416
sr-01000367198
SR-01000367198-1
1-(1-benzotriazolyl)-3-(2-methylphenoxy)-2-propanol
Q27182761
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzotriazoles
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (9)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency21.33130.007215.758889.3584AID588342
BRCA1Homo sapiens (human)Potency12.58930.89137.722525.1189AID624202
ATAD5 protein, partialHomo sapiens (human)Potency16.08920.004110.890331.5287AID504466; AID504467
P53Homo sapiens (human)Potency44.66840.07319.685831.6228AID504706
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency2.51190.01262.451825.0177AID485313
chromobox protein homolog 1Homo sapiens (human)Potency89.12510.006026.168889.1251AID540317
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency5.80480.00419.984825.9290AID504444
ras-related protein Rab-9AHomo sapiens (human)Potency3.54810.00022.621531.4954AID485297
survival motor neuron protein isoform dHomo sapiens (human)Potency11.22020.125912.234435.4813AID1458
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]