(Trifluoromethyl)-trimethylsilane, also known as **TMS-CF3**, is an organosilicon compound with the chemical formula (CH3)3SiCF3.
Here's why it's important for research:
* **Versatile Reagent for Trifluoromethylation:** TMS-CF3 is a key reagent in organic synthesis, particularly for the introduction of trifluoromethyl groups (CF3) into molecules. Trifluoromethyl groups are known to enhance a molecule's properties, such as:
* **Pharmacological activity:** Trifluoromethyl groups can increase a molecule's metabolic stability, enhance its binding affinity to biological targets, and improve its bioavailability.
* **Material properties:** They can increase a material's lipophilicity, thermal stability, and resistance to oxidation.
* **Convenient and Safe Handling:** Compared to other trifluoromethylating reagents, TMS-CF3 offers several advantages:
* **Liquid at room temperature:** This makes it easier to handle and transfer than gaseous reagents.
* **Relatively stable:** It can be stored for extended periods under inert conditions.
* **Low toxicity:** It's generally considered safer than other trifluoromethylating reagents.
* **Diverse Applications:** TMS-CF3 has found applications in:
* **Medicinal Chemistry:** Synthesis of pharmaceuticals and agrochemicals.
* **Material Science:** Development of new polymers, coatings, and other materials with improved properties.
* **Organic Synthesis:** Creation of novel organic compounds with desired functionalities.
**How it works:**
TMS-CF3 acts as a source of the trifluoromethyl group (CF3). It can be used in conjunction with various catalysts and reaction conditions to introduce the CF3 group into a wide range of substrates. The reaction typically involves the generation of a trifluoromethyl anion (CF3-), which then attacks the desired substrate.
**Examples of Applications:**
* Synthesis of anti-inflammatory drugs
* Development of new herbicides and pesticides
* Creation of high-performance polymers with improved thermal stability
* Preparation of fluorinated building blocks for the synthesis of complex organic molecules
**Overall, (trifluoromethyl)-trimethylsilane is a versatile and important reagent for researchers in various fields, enabling the efficient introduction of trifluoromethyl groups into molecules, leading to the development of new and improved compounds with enhanced properties.**
(trifluoromethyl)-trimethylsilane: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 552549 |
| SCHEMBL ID | 5253 |
| MeSH ID | M0514528 |
| Synonym |
|---|
| trimethyl(trifluoromethyl)silane, 99% |
| ruppert's reagent |
| 81290-20-2 |
| trimethyl(trifluoromethyl)silane |
| T1570 |
| (trimethylsilyl)trifluoromethane |
| (trifluoromethyl)trimethylsilane |
| ruppert-prakash reagent |
| AKOS000121141 |
| trimethyl-trifluoromethyl-silane |
| tfmtms |
| trifluoromethyltrimethylsilane |
| FT-0605358 |
| AB03965 |
| FD2097 |
| SCHEMBL5253 |
| J-502572 |
| (trifluromethyl)trimethylsilane |
| (trifluoromethyl) trimethylsilane |
| trifluoro methyltrimethylsilane |
| (trifluoromethyl)-trimethyl silane |
| trimethyl (trifluoromethyl) silane |
| cf3tms |
| tms-cf3 |
| (trifluoromethyl)-trimethylsilane |
| trifluoromethyltrimethyl silane |
| trimethyl(trifluoromethyl) silane |
| cf3-tms |
| trimethylsilyl trifluoromethane |
| trifluoromethyl trimethyl silane |
| trimethyl(trifluoro-methyl)silane |
| trifluoromethyltrimethyl-silane |
| trifluoromethyl(trimethyl)silane |
| (trifluoromethyl)trimethyl silane |
| trimethyl(trifluormethyl)-silane |
| trifluorotrimethylsilylmethane |
| trimethyltrifluoromethylsilane |
| cf3sime3 |
| trimethylsilyl-trifluoromethane |
| trifluoromethytrimethyl silane |
| trimethylsilyltrifluoromethane |
| tmscf3 |
| trifluoromethyl trimethylsilane |
| trimethyl (trifluoromethyl)silane |
| trimethyl-(trifluoromethyl)silane |
| trimethylsilyltrifluoro-methane |
| trifluoromethyl-trimethylsilane |
| trifluoromethyl-trimethyl silane |
| trifluoromethyl(trimethyl)-silane |
| me3sicf3 |
| trifluoromethyltrimetylsilane |
| trimethyl(trifluoromethyl)silane # |
| tmscf(3) |
| unii-a009786qpj |
| trifluoro(trimethylsilyl)methane |
| A009786QPJ , |
| trifluoromethyltrimethylsilane [mi] |
| silane, trimethyl(trifluoromethyl)- |
| (trifluoromethyl)trimethylsilane, 0.5m in tetrahydrofuran |
| mfcd00145454 |
| F0001-2096 |
| trimethyl(trifluoromethyl)silane, purum, >=98.0% (gc) |
| DTXSID20338998 |
| (trifluoromethyl)trimethylsilane;tms-cf3 |
| CS-0008418 |
| AS-48932 |
| BCP14634 |
| Q651896 |
| AMY6851 |
| trimethylsilyl(trifluoromethane) |
| (trifluoromethyl)trimethylsilane [trifluoromethylating reagent] |
| (trifluoromethyl)trimethylsilane 0.5m soln. in thf |
| EN300-25971 |
| c4h9f3si |
| BP-31162 |
| HY-Y0147 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (21.88) | 29.6817 |
| 2010's | 20 (62.50) | 24.3611 |
| 2020's | 5 (15.63) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (31.04) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (3.13%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 31 (96.88%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||