(sulfobromophthalein)glutathione conjugate profile

## (Sulfobromophthalein)glutathione conjugate: A key player in drug metabolism and research

**(Sulfobromophthalein)glutathione conjugate** (BSP-GSH) is a compound formed when **sulfobromophthalein** (BSP), a dye commonly used in medical research, reacts with **glutathione** (GSH), a small molecule with antioxidant properties. This conjugation reaction is a vital process in the liver's detoxification system.

**Why is BSP-GSH important for research?**

1. **Indicator of hepatic function:**
- BSP is taken up by the liver and processed through several enzymatic reactions, eventually forming BSP-GSH.
- The rate of this conjugation process is directly correlated with the liver's ability to detoxify substances.
- Measuring BSP-GSH levels in blood can therefore provide a sensitive indicator of liver function, particularly in situations like liver disease or drug toxicity.

2. **Model for drug metabolism:**
- BSP is a good model substrate for studying the liver's drug metabolism processes.
- Understanding how BSP is metabolized and conjugated to GSH helps researchers understand how other drugs are handled by the liver.
- This knowledge is crucial for drug development, enabling researchers to predict potential toxicity and optimize drug efficacy.

3. **Investigating glutathione's role:**
- BSP-GSH formation highlights the crucial role of glutathione in detoxification.
- Researching the formation and breakdown of BSP-GSH helps elucidate the mechanisms underlying glutathione's antioxidant and protective functions.
- This information is valuable for studying various diseases related to oxidative stress and glutathione depletion.

4. **Developing new drugs:**
- Understanding the factors affecting BSP-GSH formation can guide the development of new drugs that target specific metabolic pathways.
- By modifying the chemical structure of BSP or other compounds, researchers can create drugs that are more effectively metabolized or have specific effects on the liver.

**In conclusion, (sulfobromophthalein)glutathione conjugate is a valuable tool for researchers studying liver function, drug metabolism, and the role of glutathione in detoxification. Understanding this conjugate provides crucial insights for drug development, disease diagnosis, and therapeutic interventions.**

ID Source	ID
PubMed CID	162696
MeSH ID	M0109505

Synonym
(sulfobromophthalein)glutathione conjugate
glycine, n-(n-l-gamma-glutamyl-l-cysteinyl)-, mixt. with disodium 3,3'-(4,5,6,7-tetrabromo-3-oxo-1(3h)-isobenzofuranylidene)bis(6-hydroxybenzenesulfonate)
glutathione-sulfobromophthalein conjugate
bsp-sg
52682-84-5
DTXSID70200651
disodium;(2s)-2-amino-5-[[(2r)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid;2-hydroxy-5-[4,5,6,7-tetrabromo-1-(4-hydroxy-3-sulfonatophenyl)-3-oxo-2-benzofuran-1-yl]benzenesulfonate

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	7 (50.00)	18.7374
1990's	6 (42.86)	18.2507
2000's	1 (7.14)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	1.97	1	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
sulfobromophthalein Sulfobromophthalein: A phenolphthalein that is used as a diagnostic aid in hepatic function determination.	3.98	14	2-benzofurans; organobromine compound; organosulfonic acid; phenols	dye
sucrose Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.	1.98	1	glycosyl glycoside	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; sweetening agent
taurocholic acid Taurocholic Acid: The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.. taurocholate : An organosulfonate oxoanion that is the conjugate base of taurocholic acid.. taurocholic acid : A bile acid taurine conjugate of cholic acid that usually occurs as the sodium salt of bile in mammals.	2	1	amino sulfonic acid; bile acid taurine conjugate	human metabolite
isoxazoles Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.	1.98	1	isoxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
thiazoles [no description available]	2	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	1.98	1	dihydrogen
daunorubicin Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.. daunorubicin : A natural product found in Actinomadura roseola.	1.97	1	aminoglycoside antibiotic; anthracycline; p-quinones; tetracenequinones	antineoplastic agent; bacterial metabolite
glutathione disulfide Glutathione Disulfide: A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.	1.96	1	glutathione derivative; organic disulfide	Escherichia coli metabolite; mouse metabolite
grepafloxacin grepafloxacin: structure in first source	2	1	fluoroquinolone antibiotic; quinolines; quinolone antibiotic
dibromosulphthalein dibromosulphthalein: RN refers to 3H-labeled parent compound	1.96	1
s-(2,4-dinitrophenyl)glutathione S-(2,4-dinitrophenyl)glutathione : A glutathione conjugate in which the thiol hydrogen of glutathione has been replaced by a 2,4-dinitrophenyl group.	2	1	glutathione conjugate
acivicin [no description available]	1.98	1	isoxazoles; non-proteinogenic L-alpha-amino acid; organochlorine compound	antileishmanial agent; antimetabolite; antimicrobial agent; antineoplastic agent; EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor; glutamine antagonist; metabolite
e 3040 E 3040: a dual inhibitor of 5-lipoxygenase and thromboxane A2 synthetase; structure given in first source	2	1	benzothiazoles; organic hydroxy compound; pyridines; secondary amino compound	anti-inflammatory drug; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; uricosuric drug
diethyl maleate diethyl maleate : A maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. A colourless liquid at room temperature (m.p. -10degreeC) with boiling point 220degreeC at 1 atm., it is commonly used as a dienophile for Diels-Alder-type cycloaddition reactions in organic synthesis.	1.96	1	ethyl ester; maleate ester	glutathione depleting agent
bilirubin [no description available]	1.97	1	biladienes; dicarboxylic acid	antioxidant; human metabolite; mouse metabolite
leukotriene c4 Leukotriene C4: The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990). leukotriene C4 : A leukotriene that is (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid in which a glutathionyl group is attached at position 6 via a sulfide linkage.	2	1	leukotriene	bronchoconstrictor agent; human metabolite; mouse metabolite
indocyanine green Indocyanine Green: A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.	1.96	1	1,1-diunsubstituted alkanesulfonate; benzoindole; cyanine dye
bucladesine Bucladesine: A cyclic nucleotide derivative that mimics the action of endogenous CYCLIC AMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. (From Merck Index, 11th ed). bucladesine : A 3',5'-cyclic purine nucleotide that is the 2'-butanoate ester and 6-N-butanoyl derivative of 3',5'-cyclic AMP.	1.98	1	3',5'-cyclic purine nucleotide

Condition	Relationship Strength	Studies
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	2.35	2
Electrolytes Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)	1.96	1
Cancer of Liver [description not available]	1.98	1
Liver Neoplasms Tumors or cancer of the LIVER.	1.98	1
Hepatoblastoma A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)	1.98	1
Bilirubinemia [description not available]	1.98	1
Hyperbilirubinemia, Hereditary Inborn errors of bilirubin metabolism resulting in excessive amounts of bilirubin in the circulating blood, either because of increased bilirubin production or because of delayed clearance of bilirubin from the blood.	1.97	1

(sulfobromophthalein)glutathione conjugate

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Research Demand Index: 11.37

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