Page last updated: 2024-12-09

(s-acetamidomethyl)cysteine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

**(S)-acetamidomethyl cysteine**, also known as **Acm-cysteine**, is a modified amino acid that is commonly used in research. It is essentially cysteine with an acetamidomethyl group (-CH2-NH-COCH3) attached to its sulfur atom.

Here's why (S)-acetamidomethyl cysteine is important in research:

**1. Protection of cysteine residues:**

* **Cysteine** is a very reactive amino acid, with its thiol group (-SH) prone to oxidation and other modifications. This can interfere with the function of proteins, particularly enzymes.
* **Acm-cysteine** serves as a **protecting group** for cysteine residues. The acetamidomethyl group blocks the reactivity of the thiol group, preventing unwanted modifications. This is especially useful during protein synthesis or when working with proteins that contain cysteine residues essential for their function.

**2. Synthesis of peptides and proteins:**

* **Solid-phase peptide synthesis (SPPS)** is a common method for synthesizing peptides and proteins.
* **Acm-cysteine** is often used in SPPS because its protecting group can be selectively removed under mild conditions, allowing for the introduction of cysteine residues at specific positions in the peptide sequence.

**3. Studying protein structure and function:**

* By introducing **Acm-cysteine** into a protein, researchers can study the role of cysteine residues in protein folding, stability, and interactions with other molecules.
* **The removal of the protecting group** can be used to study the reactivity of specific cysteine residues in a protein. This can be useful for understanding enzyme mechanisms or identifying the binding sites of drugs or other molecules.

**4. Development of new drugs and therapies:**

* **Acm-cysteine** has been used in the development of new drugs and therapies, particularly in areas like cancer treatment and drug delivery.
* **The ability to modify cysteine residues** allows for the creation of novel protein-based therapeutics with enhanced properties.

**In summary,** (S)-acetamidomethyl cysteine is a valuable tool for researchers studying protein structure, function, and synthesis. Its ability to protect cysteine residues, facilitate peptide synthesis, and enable controlled modification makes it crucial for a wide range of applications in biochemistry, biotechnology, and pharmaceutical research.

(S-acetamidomethyl)cysteine: RN given refers to parent cpd & (L)-isomer; RN for cpd without isomeric designation not avail 3/93 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID1590100
SCHEMBL ID210387
MeSH IDM0213366

Synonyms (27)

Synonym
(s-acetamidomethyl)cysteine
(2r)-3-(acetamidomethylsulfanyl)-2-aminopropanoic acid
unii-sy9a2w0w25
sy9a2w0w25 ,
19647-70-2
einecs 243-201-0
s-(acetamidomethyl)-l-cysteine
l-cysteine, s-[(acetylamino)methyl]-
SCHEMBL210387
s-acetamidomethyl-l-cysteine
QFQYGJMNIDGZSG-YFKPBYRVSA-N
AKOS024264558
s-[(acetylamino)methyl]-l-cysteine
acetamidomethylcysteine
l-cysteine, s-((acetylamino)methyl)-
STL558034
Q27459003
(2r)-2-amino-3-[(acetamidomethyl)sulfanyl]propanoic acid
h-cys(acm)-oh
(r)-3-((acetamidomethyl)thio)-2-aminopropanoic acid
s-(acetamidomethyl)cysteine
s-((acetylamino)methyl)-l-cysteine
alanine, 3-((acetamidomethyl)thio)-, l-
HY-148667
CS-0636612
AS-82060
EN300-302432
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (75.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.42

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.42 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.42)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]