(de-nh2)phe(19)-ala(24)-pro(26)psi(ch2nh)-phe(27)-grp (19-27) profile

Let's break down this chemical notation and understand its significance in research.

**Decoding the Notation:**

* **(de-NH2)Phe(19):** This refers to a phenylalanine (Phe) amino acid residue at position 19 in a peptide chain. The (de-NH2) part means that the amino group (NH2) normally found on the amino acid has been removed.
* **Ala(24):** This is an alanine (Ala) residue at position 24.
* **Pro(26):** This is a proline (Pro) residue at position 26.
* **psi(CH2NH)-Phe(27):** This indicates a modified phenylalanine at position 27. psi(CH2NH) represents a specific modification where the standard peptide bond (CO-NH) is replaced with a CH2NH group. This is often used to mimic the geometry of a proline residue.
* **Grp(19-27):** This likely refers to a growth hormone releasing peptide (GHRP). It's a fragment encompassing positions 19-27 within a larger peptide chain.

**In Summary:**

The notation describes a specific peptide sequence where a phenylalanine at position 19 has been modified, followed by a specific sequence of other amino acids, culminating in a modified phenylalanine at position 27.

**Research Importance:**

* **GHRPs and Growth Hormone Regulation:** GHRPs are a type of peptide that can stimulate the release of growth hormone (GH) from the pituitary gland. Growth hormone plays a crucial role in many bodily functions, including growth, metabolism, and cell repair.
* **Investigating Structure-Activity Relationships:** By modifying the peptide sequence, researchers can investigate how specific amino acid changes affect the binding of the GHRP to its receptor and its ability to stimulate GH release. This helps understand the structure-activity relationship of these peptides.
* **Developing New Therapeutics:** Modifications to the peptide sequence, such as the replacement of the peptide bond with CH2NH, could improve the stability and pharmacological properties of GHRPs. This could lead to the development of new therapeutic drugs for conditions related to growth hormone deficiency.

**Example:**

This notation could be describing a specific synthetic peptide derivative of a GHRP, designed to enhance its activity, stability, or target specific receptors. Researchers might use this peptide to study how specific modifications affect GH release or to develop potential therapeutic agents for GH deficiency.

**Note:** For specific details on the importance of this particular sequence, you would need to refer to the original research publication or context in which this notation appears.

BW 10: potently inhibits bombesin evoked release of gastrointestinal hormones in vitro & in vivo [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	164442
MeSH ID	M0208998

Synonym
bw 10
(2r)-1-[(2s)-2-[[(2r)-2-[[(2s)-2-[[(2s)-2-aminopropanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-(1h-imidazol-5-yl)propanoyl]-n-[(2s)-1-[[(2s)-2-[[(2s)-3-(1h-imidazol-5-yl)-2-(3-phenylpropanoylamino)propanoyl]amino]-3-(1h-indol-3-yl)propyl]amino]
d-alaninamide, n-(1-oxo-3-phenylpropyl)-l-histidyl-l-tryptophl-l-alanyl-l-valyl-n-(2-(2-(((2-amino-2-oxo-1-(phenylmethyl)ethyl)amino)methyl)-1-pyrrolidinyl)-1-(1h-imidazol-4-ylmethyl)-2-oxoethyl)-, (2r-(1(s),2r(s*)))-
grp (19-27),(de-nh2)phenylalanyl(19)-alanyl(24)-prolyl(26)psi(ch2nh)-phenylalanine(27)-
((des-nh2)phe(19)-d-ala(24)-d-pro(26)psi(ch2nh)phe(27))-grp(19-27)
bw2258u89
(de-nh2)phe(19)-ala(24)-pro(26)psi(ch2nh)-phe(27)-grp (19-27)
bw 2258u89
grp (19-27), (de-nh2)phe(19)-ala(24)-pro(26)psi(ch2nh)phe(27)-
2258u89
bw-10
(2s)-n-[(2r)-1-[[(2s)-1-[(2r)-2-[[[(2s)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]methyl]pyrrolidin-1-yl]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-[[(2s)-2-[[(2s)-2-[[(2s)-3-(1h-imidazol-5-yl)-2-(3-phenylpropanoylamino)propanoyl]amin

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (8.33)	18.7374
1990's	8 (66.67)	18.2507
2000's	1 (8.33)	29.6817
2010's	2 (16.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	1.98	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
capsaicin ALGRX-4975: an injectable capsaicin (TRPV1 receptor agonist) formulation for longlasting pain relief. capsaicinoid : A family of aromatic fatty amides produced as secondary metabolites by chilli peppers.	2	1	capsaicinoid	non-narcotic analgesic; TRPV1 agonist; voltage-gated sodium channel blocker
granisetron Granisetron: A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.. granisetron : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 1-methyl-1H-indazole-3-carboxylic acid with the primary amino group of (3-endo)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine. A selective 5-HT3 receptor antagonist, it is used (generally as the monohydrochloride salt) to manage nausea and vomiting caused by cancer chemotherapy and radiotherapy, and to prevent and treat postoperative nausea and vomiting.	2	1	aromatic amide; indazoles
neuromedin c neuromedin C: decapeptide isolated from porcine spinal cord; corresponds to the C-terminal decapeptide of gastrin-releasing peptide; bombesin-like peptide; RN given refers to all (L)-isomer	2.43	2
bombesin (6-13), phe(6) methyl ester- bombesin (6-13), Phe(6) methyl ester-: bombesin antagonist	1.98	1
sincalide Sincalide: An octapeptide hormone present in the intestine and brain. When secreted from the gastric mucosa, it stimulates the release of bile from the gallbladder and digestive enzymes from the pancreas.	1.98	1	oligopeptide
bombesin, tyr(4)- [no description available]	1.98	1
gastrins Gastrins: A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.	2.39	2
glucagon Glucagon: A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511). glucagon : A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.	1.99	1	peptide hormone
gastrin releasing peptide (14-27) gastrin releasing peptide (14-27): C-terminal portion of gastrin-releasing peptide	1.98	1
gastrin-releasing peptide Gastrin-Releasing Peptide: Neuropeptide and gut hormone that helps regulate GASTRIC ACID secretion and motor function. Once released from nerves in the antrum of the STOMACH, the neuropeptide stimulates release of GASTRIN from the GASTRIN-SECRETING CELLS.	2.7	3
oxyntomodulin Glucagon-Like Peptides: Peptides derived from proglucagon which is also the precursor of pancreatic GLUCAGON. Despite expression of proglucagon in multiple tissues, the major production site of glucagon-like peptides (GLPs) is the INTESTINAL L CELLS. GLPs include glucagon-like peptide 1, glucagon-like peptide 2, and the various truncated forms.	1.99	1

Condition	Relationship Strength	Studies
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.15	1
Carcinoma, Oat Cell [description not available]	2.39	2
Cancer of Lung [description not available]	2.39	2
Lung Neoplasms Tumors or cancer of the LUNG.	2.39	2
Carcinoma, Small Cell An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)	2.39	2
Cancer of Pancreas [description not available]	1.98	1
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	1.98	1

(de-nh2)phe(19)-ala(24)-pro(26)psi(ch2nh)-phe(27)-grp (19-27)

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Research

Studies (12)

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Research Demand Index: 12.73

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