Compounds > (asparaginyl-alanyl-asparaginyl-proline)3
Page last updated: 2024-12-11
(asparaginyl-alanyl-asparaginyl-proline)3
Description
(Asparaginyl-alanyl-asparaginyl-proline)3, often shortened to **(NAAP)3**, is a **peptide** - a short chain of amino acids. It's important in research for several reasons:
**1. Self-Assembly Properties:**
* **Nanofibril Formation:** (NAAP)3 is known to self-assemble into long, thin nanofibrils. These nanofibrils are highly ordered and can be used to create various nanostructured materials.
* **Biomimetic Material Development:** The ability of (NAAP)3 to form nanofibrils makes it a promising material for mimicking natural biomaterials like collagen and silk, which are also fibrous proteins.
**2. Biocompatibility and Biodegradability:**
* **Biocompatibility:** (NAAP)3 is considered biocompatible, meaning it doesn't elicit a harmful immune response in the body. This makes it suitable for biomedical applications.
* **Biodegradability:** The peptide is also biodegradable, breaking down into its constituent amino acids over time. This property is important for applications where a temporary or degradable material is needed.
**3. Applications in Research and Medicine:**
* **Tissue Engineering:** (NAAP)3 nanofibrils can be used as scaffolds for tissue engineering, providing a framework for cells to grow and form new tissues.
* **Drug Delivery:** (NAAP)3's ability to form nanofibrils can be exploited for controlled drug delivery. The peptide can encapsulate drugs and release them gradually over time.
* **Biosensors:** (NAAP)3 can be incorporated into biosensors to detect specific molecules, such as proteins or pathogens.
* **Nanoelectronics:** The unique properties of (NAAP)3 nanofibrils have also been explored for applications in nanoelectronics, such as in the fabrication of transistors and sensors.
**4. Research Significance:**
* **Understanding Self-Assembly:** Studying (NAAP)3 helps scientists understand the complex mechanisms of protein self-assembly and how to design new materials with specific properties.
* **Developing New Biomaterials:** The research on (NAAP)3 is driving the development of new biocompatible and biodegradable materials for various applications.
In summary, (NAAP)3 is a fascinating peptide with unique self-assembly properties, biocompatibility, and biodegradability. Its research significance lies in its potential for creating novel nanomaterials with applications in medicine, tissue engineering, drug delivery, and other fields.
(asparaginyl-alanyl-asparaginyl-proline)3: 12-amino acid synthetic peptide derived from the repeating amino acid sequence found in the surface circumsporozoite protein of Plasmodium falciparum sporozoites; consists of 3 repeating units of Asn-Ala-Asn-Pro [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
PubMed CID | 5489385 |
MeSH ID | M0150150 |
Synonyms (6)
Synonym |
(nanp)3 |
(asparaginyl-alanyl-asparaginyl-proline)3 |
l-proline, 1-(n2-(n-(n2-(1-(n2-(n-(n2-(1-(n2-(n-l-asparaginyl-l-alanyl)-l-asparaginyl)-l-prolyl)-l-asparaginyl)-l-alanyl)-l-asparaginyl)-l-prolyl)-l-asparaginyl)-l-alanyl)-l-asparaginyl)- |
(asn-ala-asn-pro)3 |
97557-30-7 |
DTXSID60243037 |
Research
Studies (14)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 6 (42.86) | 18.7374 |
1990's | 5 (35.71) | 18.2507 |
2000's | 2 (14.29) | 29.6817 |
2010's | 1 (7.14) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 11.27
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
Metric | This Compound (vs All) |
---|
Research Demand Index | 11.27 (24.57) | Research Supply Index | 2.94 (2.92) | Research Growth Index | 4.21 (4.65) | Search Engine Demand Index | 0.00 (26.88) | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 1 (5.88%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 16 (94.12%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |