Page last updated: 2024-12-11

(asparaginyl-alanyl-asparaginyl-proline)3

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

(Asparaginyl-alanyl-asparaginyl-proline)3, often shortened to **(NAAP)3**, is a **peptide** - a short chain of amino acids. It's important in research for several reasons:

**1. Self-Assembly Properties:**

* **Nanofibril Formation:** (NAAP)3 is known to self-assemble into long, thin nanofibrils. These nanofibrils are highly ordered and can be used to create various nanostructured materials.
* **Biomimetic Material Development:** The ability of (NAAP)3 to form nanofibrils makes it a promising material for mimicking natural biomaterials like collagen and silk, which are also fibrous proteins.

**2. Biocompatibility and Biodegradability:**

* **Biocompatibility:** (NAAP)3 is considered biocompatible, meaning it doesn't elicit a harmful immune response in the body. This makes it suitable for biomedical applications.
* **Biodegradability:** The peptide is also biodegradable, breaking down into its constituent amino acids over time. This property is important for applications where a temporary or degradable material is needed.

**3. Applications in Research and Medicine:**

* **Tissue Engineering:** (NAAP)3 nanofibrils can be used as scaffolds for tissue engineering, providing a framework for cells to grow and form new tissues.
* **Drug Delivery:** (NAAP)3's ability to form nanofibrils can be exploited for controlled drug delivery. The peptide can encapsulate drugs and release them gradually over time.
* **Biosensors:** (NAAP)3 can be incorporated into biosensors to detect specific molecules, such as proteins or pathogens.
* **Nanoelectronics:** The unique properties of (NAAP)3 nanofibrils have also been explored for applications in nanoelectronics, such as in the fabrication of transistors and sensors.

**4. Research Significance:**

* **Understanding Self-Assembly:** Studying (NAAP)3 helps scientists understand the complex mechanisms of protein self-assembly and how to design new materials with specific properties.
* **Developing New Biomaterials:** The research on (NAAP)3 is driving the development of new biocompatible and biodegradable materials for various applications.

In summary, (NAAP)3 is a fascinating peptide with unique self-assembly properties, biocompatibility, and biodegradability. Its research significance lies in its potential for creating novel nanomaterials with applications in medicine, tissue engineering, drug delivery, and other fields.

(asparaginyl-alanyl-asparaginyl-proline)3: 12-amino acid synthetic peptide derived from the repeating amino acid sequence found in the surface circumsporozoite protein of Plasmodium falciparum sporozoites; consists of 3 repeating units of Asn-Ala-Asn-Pro [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5489385
MeSH IDM0150150

Synonyms (6)

Synonym
(nanp)3
(asparaginyl-alanyl-asparaginyl-proline)3
l-proline, 1-(n2-(n-(n2-(1-(n2-(n-(n2-(1-(n2-(n-l-asparaginyl-l-alanyl)-l-asparaginyl)-l-prolyl)-l-asparaginyl)-l-alanyl)-l-asparaginyl)-l-prolyl)-l-asparaginyl)-l-alanyl)-l-asparaginyl)-
(asn-ala-asn-pro)3
97557-30-7
DTXSID60243037
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (42.86)18.7374
1990's5 (35.71)18.2507
2000's2 (14.29)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.27

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.27 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index4.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.27)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (5.88%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (94.12%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]