(5-phenyl-3-isoxazolyl)-(1-pyrrolidinyl)methanone

(5-phenyl-3-isoxazolyl)-(1-pyrrolidinyl)methanone is a chemical compound, also known by its more common name **ISX-9**. It is a **potent and selective inhibitor of the enzyme histone deacetylase 6 (HDAC6)**.

**What is HDAC6?**

HDAC6 is an enzyme that plays a crucial role in regulating the acetylation of proteins, a process that is involved in various cellular functions, including cell growth, differentiation, and stress response.

**How does ISX-9 work?**

ISX-9 specifically binds to and inhibits HDAC6, preventing it from removing acetyl groups from proteins. This leads to an accumulation of acetylated proteins, which can have a number of effects on cellular processes.

**Why is ISX-9 important for research?**

ISX-9 has shown promising therapeutic potential in various research settings, including:

* **Cancer research:** By inhibiting HDAC6, ISX-9 can induce cell death in cancer cells and inhibit tumor growth.
* **Neurodegenerative disease research:** HDAC6 is implicated in the progression of neurodegenerative diseases like Alzheimer's and Parkinson's. ISX-9 might be useful in protecting against neuronal damage and improving cognitive function.
* **Inflammation research:** HDAC6 is involved in regulating inflammation. ISX-9 may be beneficial in treating inflammatory conditions.
* **Other areas:** Research is ongoing to explore ISX-9's potential in other areas such as wound healing and heart disease.

**Important Notes:**

* ISX-9 is currently **not approved for clinical use** in humans.
* The research on ISX-9 is ongoing, and further studies are needed to understand its full potential and any potential side effects.

**In summary,** (5-phenyl-3-isoxazolyl)-(1-pyrrolidinyl)methanone (ISX-9) is a powerful research tool that offers potential for treating various diseases by targeting the enzyme HDAC6.