(5-(3-thienyl)tetrazol-1-yl)acetic acid profile

(5-(3-thienyl)tetrazol-1-yl)acetic acid is a **heterocyclic compound** with a complex structure involving a tetrazole ring attached to a thiophene ring, further connected to an acetic acid group.

**Structure:**

* **Tetrazole Ring:** A five-membered ring containing four nitrogen atoms and one carbon.
* **Thiophene Ring:** A five-membered ring containing one sulfur atom and four carbon atoms.
* **Acetic Acid Group:** A carboxylic acid group (-COOH) attached to the tetrazole ring.

**Importance in Research:**

While (5-(3-thienyl)tetrazol-1-yl)acetic acid itself is not a well-known compound with extensive research, its structure and components are relevant in various research areas:

* **Pharmaceutical Chemistry:**
* **Tetrazoles:** Are often incorporated into drug molecules due to their ability to act as bioisosteres (mimic the properties of other functional groups).
* **Thiophenes:** Are known to enhance bioavailability and modify the pharmacological properties of drugs.
* **Carboxylic Acid:** A common functional group in drug molecules that can influence their activity and target interactions.

* **Materials Science:**
* **Heterocycles:** Can exhibit unique electronic and optical properties, making them useful in developing new materials for applications like organic electronics, sensors, and photovoltaics.

**Possible Research Directions:**

* **Synthesis and Characterization:** Synthesizing and characterizing this specific compound could provide valuable insights into its chemical properties and potential for applications.
* **Biological Activity:** Evaluating its potential biological activities could reveal its suitability for drug discovery or other therapeutic applications.
* **Material Science:** Investigating its properties for use in organic electronics or other materials science applications.

**Important Note:** The specific compound mentioned is not widely studied. Further research is required to determine its precise properties and potential applications.

(5-(3-thienyl)tetrazol-1-yl)acetic acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	3035658
SCHEMBL ID	4347946
MeSH ID	M0216141

Synonym
1h-tetrazole-1-acetic acid, 5-(3-thienyl)-
5-(3-thienyl)tetrazol-1-ylacetic acid
5-(3-thienyl)-1h-tetrazole-1-acetic acid
(5-(3-thienyl)tetrazol-1-yl)acetic acid
SCHEMBL4347946
2-(5-thiophen-3-yltetrazol-1-yl)acetic acid
134717-73-0
1h-tetrazole-1-aceticacid, 5-(3-thienyl)-
AKOS015155635
[5-(3-thienyl)tetrazol-1-yl]acetic acid
[5-(3-thienyl) tetrazol-1-yl] acetic acid
[5-(3-thienyl) tetrazol-1-yl]acetic acid
DDVAZOPRCKAYOV-UHFFFAOYSA-N
[5-(3-thienyl)tetrazol-1-yl] acetic acid
DTXSID10158900
CCG-352908
wp 921
2-[5-(3-thienyl)-1-tetrazolyl]acetic acid
wp921
2-[5-(thiophen-3-yl)-1h-1,2,3,4-tetrazol-1-yl]acetic acid
2-[5-(thiophen-3-yl)-1h-1,2,3,4-tetrazol-1-yl]aceticacid
EN300-252256
Z1269222962

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	9 (90.00)	18.2507
2000's	1 (10.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetylcarnitine Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.	1.99	1	O-acylcarnitine	human metabolite
2,3-diphosphoglycerate 2,3-Diphosphoglycerate: A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508). 2,3-bisphosphoglyceric acid : A bisphosphoglyceric acid that is glyceric acid carrying two phospho substituents at positions 2 and 3.	2.69	3	bisphosphoglyceric acid; tetronic acid derivative	human metabolite
carnitine [no description available]	2.4	2	amino-acid betaine	human metabolite; mouse metabolite
inositol Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.. inositol : Any cyclohexane-1,2,3,4,5,6-hexol.. 1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.. muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.	1.98	1	cyclitol; hexol
cilostazol [no description available]	1.99	1	lactam; tetrazoles	anticoagulant; bronchodilator agent; EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor; fibrin modulating drug; neuroprotective agent; platelet aggregation inhibitor; vasodilator agent
sorbitol D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).	2.9	4	glucitol	cathartic; Escherichia coli metabolite; food humectant; human metabolite; laxative; metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite; sweetening agent
sucrose Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.	1.99	1	glycosyl glycoside	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; sweetening agent
adenosine diphosphate Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.	2.39	2	adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	fundamental metabolite; human metabolite
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	3.69	10	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
propionylcarnitine propionylcarnitine: RN given refers to cpd without isomeric designation	1.99	1	O-acylcarnitine	analgesic; antirheumatic drug; cardiotonic drug; human metabolite; peripheral nervous system drug
D-fructopyranose [no description available]	2.68	3	cyclic hemiketal; D-fructose; fructopyranose	sweetening agent

Condition	Relationship Strength	Studies
Alloxan Diabetes [description not available]	3.37	7
Asymmetric Diabetic Proximal Motor Neuropathy [description not available]	3.37	7
Diabetic Neuropathies Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)	3.37	7
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	3.09	5
Diabetic Retinopathy Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.	2.68	3
Diabetes Mellitus, Adult-Onset [description not available]	2.69	3
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	1.99	1
Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.	2.69	3
Diabetic Angiopathies VASCULAR DISEASES that are associated with DIABETES MELLITUS.	1.99	1
Hyperglycemia, Postprandial Abnormally high BLOOD GLUCOSE level after a meal.	2	1
Hyperglycemia Abnormally high BLOOD GLUCOSE level.	2	1

(5-(3-thienyl)tetrazol-1-yl)acetic acid

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