Assay ID | Title | Year | Journal | Article |
AID754726 | Activity at rat recombinant GluN1/GluN2D receptor expressed in Xenopus oocytes assessed as potentiation of glycine/glutamate-induced activation at 10 uM by two-electrode voltage clamp technique relative to control | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. |
AID754728 | Activity at rat recombinant GluN1/GluN2B receptor expressed in Xenopus oocytes assessesed as potentiation of glycine/glutamate-induced effect at 10 uM by two-electrode voltage clamp technique | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. |
AID1512718 | Positive allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channel current by two electrode voltage clamp method | 2019 | Journal of medicinal chemistry, 01-10, Volume: 62, Issue:1
| Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action. |
AID1669091 | Positive allosteric modulation of recombinant rat GluN1a/GluN2C receptor expressed in Xenopus laevis oocytes assessed as increase in glycine/L-glutamate-induced channel current at 30 uM by two-electrode voltage clamp method relative to control | | | |
AID1512720 | Positive allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channel current by two electrode voltage clamp method | 2019 | Journal of medicinal chemistry, 01-10, Volume: 62, Issue:1
| Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action. |
AID1669090 | Aqueous solubility of the compound at pH 7.4 after 30 mins by nephelometric analysis | | | |
AID1669112 | Protein binding in rat plasma at 1 uM measured after 60 mins by equilibrium dialysis based LC/MS/MS analysis | | | |
AID1669086 | Positive allosteric modulation of recombinant rat GluN1a/GluN2C receptor expressed in Xenopus laevis oocytes assessed as increase in glycine/L-glutamate-induced channel current by two-electrode voltage clamp method | | | |
AID754723 | Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp technique | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. |
AID754725 | Activity at rat recombinant GluN1/GluN2C receptor expressed in Xenopus oocytes assessed as potentiation of glycine/glutamate-induced activation at 10 uM by two-electrode voltage clamp technique relative to glycine/glutamate | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. |
AID1669101 | Fraction unbound in rat plasma at 1 uM measured after 60 mins by equilibrium dialysis based LC/MS/MS analysis | | | |
AID1669102 | Cmax in C57Bl/6 mouse at 20 mg/kg, ip by LC/MS/MS analysis | | | |
AID754719 | Activity at rat recombinant GluN1/GluN2D receptor expressed in Xenopus oocytes assessed as potentiation of 0.3 uM glycine/0.1 uM glutamate-induced activation at 10 uM by two-electrode voltage clamp technique relative to control | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. |
AID754623 | Activity at GluN1/GluN2C receptor in hamster BHK cells assessed as effect on NMDA-induced response up to 6 hrs by Fluo-4 dye-based fluorescence assay | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. |
AID754622 | Activity at GluN1/GluN2C receptor in hamster BHK cells assessed as effect on NMDA-induced response after 24 hrs by Fluo-4 dye-based fluorescence assay | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. |
AID1669089 | Positive allosteric modulation of recombinant rat GluN1a/GluN2D receptor expressed in Xenopus laevis oocytes assessed as increase in glycine/L-glutamate-induced channel current by measuring log of doubling concentration by two-electrode voltage clamp meth | | | |
AID754727 | Activity at rat recombinant GluN1/GluN2C receptor expressed in Xenopus oocytes assessed as potentiation of glycine/glutamate-induced activation at 10 uM by two-electrode voltage clamp technique relative to control | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. |
AID1669104 | Ratio of drug level in brain to plasma in C57Bl/6 mouse at 20 mg/kg, ip by LC/MS/MS analysis | | | |
AID1669087 | Positive allosteric modulation of recombinant rat GluN1a/GluN2D receptor expressed in Xenopus laevis oocytes assessed as increase in glycine/L-glutamate-induced channel current by two-electrode voltage clamp method | | | |
AID754722 | Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp technique | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. |
AID754624 | Activity at rat recombinant GluK2 receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced response by two-electrode voltage clamp technique | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. |
AID754724 | Activity at rat recombinant GluN1/GluN2D receptor expressed in Xenopus oocytes assessed as potentiation of glycine/glutamate-induced activation at 10 uM by two-electrode voltage clamp technique relative to glycine/glutamate | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. |
AID1669103 | Half life in C57Bl/6 mouse at 20 mg/kg, ip by LC/MS/MS analysis | | | |
AID1669092 | Positive allosteric modulation of recombinant rat GluN1a/GluN2D receptor expressed in Xenopus laevis oocytes assessed as increase in glycine/L-glutamate-induced channel current at 30 uM by two-electrode voltage clamp method relative to control | | | |
AID754729 | Activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus oocytes assessesed as potentiation of glycine/glutamate-induced effect at 10 uM by two-electrode voltage clamp technique | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. |
AID1512719 | Positive allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channel current by two electrode voltage clamp method | 2019 | Journal of medicinal chemistry, 01-10, Volume: 62, Issue:1
| Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action. |
AID1669088 | Positive allosteric modulation of recombinant rat GluN1a/GluN2C receptor expressed in Xenopus laevis oocytes assessed as increase in glycine/L-glutamate-induced channel current by measuring log of doubling concentration by two-electrode voltage clamp meth | | | |
AID1512717 | Positive allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channel current by two electrode voltage clamp method | 2019 | Journal of medicinal chemistry, 01-10, Volume: 62, Issue:1
| Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action. |
AID754625 | Activity at rat recombinant GluA1 receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced response by two-electrode voltage clamp technique | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
| Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. |
AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6
| A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | | | |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |