Page last updated: 2024-12-06

(2.2)paracyclophane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

(2.2)Paracyclophane is a fascinating molecule with a unique structure and interesting properties, making it a valuable tool in research across various fields. Let's break down its significance:

**What is (2.2)Paracyclophane?**

(2.2)Paracyclophane is a synthetic organic molecule belonging to the class of **cyclophanes**. It consists of two benzene rings linked by two ethylene bridges, forming a rigid cage-like structure.

* **Key Structural Features:**
* **Bridged Benzene Rings:** The two benzene rings are held in close proximity by the ethylene bridges.
* **Strain:** The molecule experiences significant strain due to the forced proximity of the aromatic rings and the bent conformation of the ethylene bridges.
* **Non-Planar Benzene:** The benzene rings are distorted from their usual planar geometry due to the bridge constraints.

**Why is it Important for Research?**

(2.2)Paracyclophane serves as a valuable model system and reagent in numerous research areas:

* **Organic Chemistry:**
* **Strain Effects:** Its highly strained structure allows researchers to study the effects of strain on chemical reactivity and molecular properties.
* **Synthesis of Complex Molecules:** The rigid, pre-organized structure facilitates the synthesis of complex molecules with unique topologies.
* **Stereochemistry:** The non-planar benzene rings introduce a new dimension to stereochemical studies.
* **Physical Chemistry:**
* **Electronic Properties:** The strain and distorted aromatic rings impact the electronic properties of the molecule, making it useful for understanding electronic interactions in complex systems.
* **Spectroscopy:** The unique structure provides distinctive spectroscopic features that can be analyzed to study molecular dynamics and interactions.
* **Material Science:**
* **Supramolecular Chemistry:** The rigid, cage-like structure allows for the creation of supramolecular assemblies with tailored properties.
* **Organic Electronics:** Its unique electronic properties make it a potential candidate for use in organic electronic devices.
* **Biochemistry:**
* **Molecular Recognition:** Its specific shape and functionalization possibilities make it a promising tool for studying molecular recognition processes.
* **Drug Delivery:** The cage-like structure can be used to encapsulate and deliver drugs or other therapeutic agents.

**In Conclusion:**

(2.2)Paracyclophane's unique structure, combined with its interesting properties, has made it a versatile tool in numerous scientific fields. Researchers continue to explore its potential for understanding fundamental principles, designing new materials, and developing innovative applications in various disciplines.

(2.2)paracyclophane: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID74210
CHEMBL ID3278516
MeSH IDM0504577

Synonyms (56)

Synonym
unii-0i9pqb142o
0i9pqb142o ,
[2.2] paracyclophane
[2.2]paracyclophane ,
tricyclo[8.2.2.2(4,7)]hexadeca-4,6,10,12,13,15-hexaene
di-1,4-xylylene
cyclobis(benzene-1,4-dimethylene)
tricyclo[8.2.2.24,6,10,12,13,15-hexaene
nsc-91575
di-p-xylylene
nsc91575
tricyclo[8.2.2.2~4,7~]hexadeca-1(12),4,6,10,13,15-hexaene
inchi=1/c16h16/c1-2-14-4-3-13(1)9-10-15-5-7-16(8-6-15)12-11-14/h1-8h,9-12h
1633-22-3
tricyclo[8.2.2.2~4,7~]hexadeca-4,6,10,12,13,15-hexaene
(2,2)-paracyclophane
[2.2]paracyclophane, 97%
(2.2)paracyclophane
einecs 216-644-2
nsc 91575
tricyclo(8.2.2.24,7)hexadeca-4,6,10,12,13,15-hexaene
tricyclo(8.2.2.24,7)hexadeca-1(12),4,6,10,13,15-hexaene
[2.2]paracyclophan
P1165
AKOS004909031
di-p-xylylene; tricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaene;[2.2]paracyclophane
A18271
tricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaene
paracyclophane
tricyclo[8,2,2,24,7]hexadeca-4,6,10,12,13,15-hexaene
FT-0605407
AM20030101
CHEMBL3278516
STL324933
DTXSID9061835
SY018426
mfcd00003707
[2,2]-paracyclophane
OOLUVSIJOMLOCB-UHFFFAOYSA-N
tricyclo[8.2.2.2<4,7>]hexadeca-4,6,10,12,13,15-hexaene
[2.2]-paracyclophane
W-107955
CS-W015206
(2.2)-paracyclophane
[2,2]paracyclophane
parylene dimer
(2.2)-p-cyclophane
(2.2)(1,4)cyclophane
1,4-carbophane
AS-15801
F10672
tricyclo[8.2.2.24,7]hexadeca-1(13),4,6,10(14),11,15-hexaene
1,4(1,4)-dibenzenacyclohexaphane
AB89907
tricyclo[8.2.2.2,4,7]hexadeca-1(12),4,6,10,13,15-hexaene
EN300-111823
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1145576Octanol-water partition coefficient, log P of the compound1976Journal of medicinal chemistry, May, Volume: 19, Issue:5
Partition coefficients and surface areas of some alkylbenzenes.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (26)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (3.85)18.7374
1990's0 (0.00)18.2507
2000's8 (30.77)29.6817
2010's17 (65.38)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 38.14

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index38.14 (24.57)
Research Supply Index3.30 (2.92)
Research Growth Index4.46 (4.65)
Search Engine Demand Index51.30 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (38.14)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.85%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other25 (96.15%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]