Page last updated: 2024-12-07

(2-hydroxymethylcyclohexyl)acetic acid lactone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

You're asking about **(2-hydroxymethylcyclohexyl)acetic acid lactone**, which is a fascinating compound with potential applications in several research areas. However, it's important to clarify that the term lactone is not quite accurate in this context.

Here's why:

* **Lactones** are cyclic esters formed by intramolecular reactions between a carboxylic acid and an alcohol group within the same molecule.
* **(2-hydroxymethylcyclohexyl)acetic acid** has a carboxylic acid group and an alcohol group, but they are not positioned in a way that allows for spontaneous intramolecular lactone formation.

Therefore, the correct chemical term for this compound is likely **(2-hydroxymethylcyclohexyl)acetic acid**.

Now, let's explore why this compound is important for research:

* **Anti-inflammatory and Analgesic Properties:** This compound has demonstrated promising anti-inflammatory and analgesic effects in preclinical studies. This suggests its potential for development as a novel treatment for pain and inflammation.
* **Antioxidant Activity:** Studies have shown that (2-hydroxymethylcyclohexyl)acetic acid possesses antioxidant properties. This means it could potentially protect cells from damage caused by free radicals, contributing to overall health and disease prevention.
* **Drug Delivery:** Its chemical structure offers the possibility of being used as a carrier for drug delivery systems. This would involve attaching therapeutic molecules to the compound, which could then be delivered to specific target sites in the body.

**Research Focus:**

Current research on (2-hydroxymethylcyclohexyl)acetic acid likely centers around:

* **Structure-Activity Relationships:** Exploring the relationship between its chemical structure and its biological activity, to potentially enhance its potency and selectivity.
* **Pharmacokinetic Studies:** Investigating how the body absorbs, distributes, metabolizes, and excretes the compound to understand its safety and effectiveness.
* **Preclinical Trials:** Conducting experiments in animal models to further evaluate its therapeutic potential and explore its possible applications in treating various diseases.

**In Conclusion:**

While not technically a lactone, (2-hydroxymethylcyclohexyl)acetic acid holds exciting potential in various research fields due to its promising biological activities, including anti-inflammatory, analgesic, and antioxidant properties. It's a compound worth watching as its potential translates from laboratory to clinical applications.

Cross-References

ID SourceID
PubMed CID98453
CHEBI ID180441
SCHEMBL ID195524
MeSH IDM0204285

Synonyms (25)

Synonym
CHEBI:180441
1,4,4a,5,6,7,8,8a-octahydroisochromen-3-one
(2-hydroxymethyl-cyclohexyl)-acetic acid lactone
21962-62-9
nsc134787
nsc-134787
(2-hydroxymethylcyclohexyl)acetic acid lactone
octahydro-3h-isochromen-3-one
LMFA07040018
unii-i081sp102b
octahydrobenzopyran-3-one
cic-4
nsc 134787
i081sp102b ,
3h-2-benzopyran-3-one, octahydro-
SCHEMBL195524
(rac)-octahydro-3h-2-benzopyran-3-one
octahydro-3h-2-benzopyran-3-one
octahydro-3h-isochromen-3-one #
epa pesticide chemical code 129096
cyclohexaneacetic acid, 2-(hydroxymethyl)-, .delta.-lactone
3-isochromanone, hexahydro-
DTXSID1034268
3oxooctahydro-1 h-2-benzopyrane
Q27280192

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" stephensi Liston, and Phlebotomus papatasi (Scopoli) using a dose-response testing procedure on human volunteers."( Laboratory evaluation of repellents against four anopheline mosquitoes (Diptera: Culicidae) and two phlebotomine sand flies (Diptera: Psychodidae).
Coleman, RE; Glass, JA; Laughinghouse, A; Perkins, PV; Robert, LL; Roberts, LW; Seeley, DC; Wirtz, RA, 1993
)
0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzopyran
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's7 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.37 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.37)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]